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Functional materials for fast diagnosis of wound infection

Objective

"Early detection of an incipient wound infection is a challenge for the attending physician , since its early diagnosis allows the timely initiation of treatment, thus reducing the severity of the disease . Currently, however, wound infection is not diagnosed until becoming already evident. As a consequence, the treatment of the patient is further complicated and more likely to have a negative outcome4. Often wounds are treated with antibiotics before even the infection appears, leading to overdoses and development of bacterial resistance to antibiotics.
Considering that optimal efficiency is reached when a material serves multiple functions without compromise, consortium partners have discovered the means to convert wound dressings into a diagnostic tool capable to inform both patient and therapist about the wound status, thus directing towards the following therapeutic step. The proposed functional materials include a real time diagnostic reaction that positively influences the wound healing due to the timely intervention to treat infection or proteolytic stasis in the wound
The novel InFact technology will be translated into a low-cost, real-time diagnostic tool as a constituent part of a wound dressing material, i.e. the ""triple-P"" materials concept:
- Protective - by a decoy substrate for destructive proteases
- Predictive – providing a cumulative wound status signal to predict the infection transition
- Proactive - changing the dressing according to a signal, rather than on a schedule base, will provide therapeutic response in time, and not too late.
More specifically, the functional materials (e.g. absorbent fibres and hydrocolloid pads) will incorporate immobilized substrates for three enzymes: myeloperoxidase, lysozyme and elastase. Upon infection, these enzymatic activities are highly elevated in wound fluids, and can be detected by the color change of the functional materials, visible via a window in the dressing."

Call for proposal

FP7-NMP-2013-SME-7
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Coordinator

UNIVERSITAET FUER BODENKULTUR WIEN
Address
Gregor Mendel Strasse 33
1180 Wien
Austria
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 661 811
Administrative Contact
Georg Guebitz (Prof.)

Participants (10)

STICHTING MEDISCH SPECTRUM TWENTE
Netherlands
EU contribution
€ 293 125
Address
Haaksbergerstraat 55
7513 ER Enschede
Activity type
Other
Administrative Contact
Job Van Der Palen (Prof.)
DI DR ANDREAS PAAR KG
Austria
EU contribution
€ 381 980
Address
Leechgasse 55/8
8010 Graz
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Andreas Paar (Dr.)
BAR ILAN UNIVERSITY
Israel
EU contribution
€ 392 320
Address
Bar Ilan University Campus
52900 Ramat Gan
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Estelle Waise (Ms.)
S.C. DAVO STAR IMPEX SRL
Romania
EU contribution
€ 307 760
Address
Str Valea Otului 77-79 Sector 6
61977 Bucharest
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Daniela Anton (Mrs.)
UNIVERSITAT POLITECNICA DE CATALUNYA
Spain
EU contribution
€ 464 231
Address
Calle Jordi Girona 31
08034 Barcelona
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Mercedes Torrellas (Ms.)
ASSOCIACAO UNIVERSIDADE EMPRESA PARA DESENVOLVIMENTO TECMINHO
Portugal
EU contribution
€ 344 760
Address
Campus De Azurem Universidade Do Minho
4800 058 Guimaraes
Activity type
Other
Administrative Contact
Fernando Ribeiro (Mr.)
SYNOVO GMBH
Germany
EU contribution
€ 489 480
Address
Paul Ehrlich Str 15
72076 Tuebingen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Michael Burnet (Dr.)
CONVATEC LIMITED
United Kingdom
EU contribution
€ 497 380
Address
Gdc First Avenue - Deeside Industrial Park
CH5 2NU Deeside Flintshire
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Philip Bowler (Mr.)
NEDERLANDSE ORGANISATIE VOOR TOEGEPAST NATUURWETENSCHAPPELIJK ONDERZOEK TNO
Netherlands
EU contribution
€ 306 046
Address
Anna Van Buerenplein 1
2595 DA Den Haag
Activity type
Research Organisations
Administrative Contact
Herman Lenting (Dr.)
OSM-DAN LTD
Israel
EU contribution
€ 199 080
Address
19 Pro Neeman Yuval St
7608665 Rehovot
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Pnina Dan (Dr.)