Cel ELABORATION AND COMPARATIVE EVALUATION OF TEST SYSTEMS FOR THE ASSESSMENT OF GENETIC EFFECTS OF ENVIRONMENTAL CHEMICALS AND OF THE PRODUCTS OF THEIR METABOLIC TRANSFORMATION. THE AIM OF THE PROJECT IS TO CONTRIBUTE TO A LONG-TERM PROGRAMME OF PRIMARY CANCER PREVENTION AIMED IDENTIFYING AND MINIMISING HUMAN EXPOSURE TO ENVIRONMENTAL AND INDUSTRIAL CARCINOGENS/MUTAGENS: A) BY SYSTEMATIC SCREENING IN MULTIPLE SHORT-TERM TESTS; B) BY VALIDATION AND IMPROVEMENT OF THE EFFICIENCY OF SUCH ASSAYS FOR THE DETECTION OF CARCINOGENS WITH THE MAIN EMPHASIS ON: 1) VALIDATION OF CELLULAR METABOLIC ACTIVATION SYSTEMS TO REVEAL DNA-DAMAGING ACTIVITY OF CARCINOGENS/MUTAGENS INCLUDING PRIMARY HEPATOCYTES FROM RAT, MOUSE AND HAMSTER IN COMBINATION WITH SALMONELLA TYPHIMURIUM STRAINS, OR V79 CHINESE HAMSTER CELLS AS GENETIC INDICATORS; 2) USING A BATTERY OF SHORT-TERM TESTS (BACTERIAL AND MAMMALIAN CELLS WITH SUB-CELLULAR, CELLULAR AND IN VIVO METABOLIC ACTIVATION) TO DETERMINE PRIORITIES FOR ENVIRONMENTAL AND INDUSTRIAL CHEMICALS TO BE SUBMITTED FOR LONG-TERM BIO-ASSAYS; 3) STUDIES TO EXAMINE WHETHER A QUANTITATIVE CORRELATION EXISTS BETWEEN POTENCY OF CARCINOGENS IN ANIMALS AND HUMANS ANS THEIR ACTIVITY IN SHORT-TERM TESTS; IN VITRO DATA ON CARCINOGENS WILL BE COMPARED WITH THEIR TD50 VALUES, IBALL'S OR IN VIVO COVALENT BINDING INDICES (CBI); 4) STUDIES ON CELL-CYCLE DEPENDENCE AND THE EFFECT OF MULTIPLE DOSES OF MUTAGENS ON THE MUTATION FREQUENCY WILL BE EXAMINED IN AN EPITHELIAL RAT LIVER CELL LINE. THE POSSIBLE ACCUMULATION OF SPECIFIC MODIFIED DNA BASES, E.G. O6-ALKYLGUANINE, AND ITS RELEVANCE TO MUTATIONS INDUCED BY ALKYLATING AGENTS WILL BE INVESTIGATED. Program(-y) PRE-ENVPROT 3C - Sectoral research and development programme (EEC) in the field of environment (environmental protection and climatology) - indirect and concerted actions - Environmental protection -, 1981-1985 Temat(-y) Data not available Zaproszenie do składania wniosków Data not available System finansowania CSC - Cost-sharing contracts Koordynator INTERNATIONAL AGENCY FOR RESEARCH ON CANCER Wkład UE Brak danych Adres Cours Albert-Thomas 150 LYON Francja Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych
