Objective
Most farmed fishes exhibit problems producing high quality eggs, which has adverse socioeconomic impacts and endangers global food security. Almost no attention has been paid to imbalance of egg proteins crucial for early development as a potential cause of poor egg quality. The major components of fish eggs are yolk proteins (YPs) derived from circulating precursors, vitellogenins (Vtgs). All fish produce multiple types of Vtg and the different types may play disparate roles in oocyte maturation and embryonic versus larval nutrition. Underlying cytological events involve complex systems of Vtg receptors, endocytotic elements, enzymes and other proteome components. Preliminary evidence that dysfunction of these systems contributes to poor egg quality has been obtained. The proposed research will exploit zebrafish, having a sequenced genome, as a laboratory model for proteomics of fish egg quality. Objectives are; 1) Molecular characterization of multiple Vtg gene structure, expression, product proteins and phylogeny, 2) Quantification of the Vtgs or their derived YPs in maternal females, oocytes, eggs and offspring of good and poor quality spawns, and 3) Identification of the most significant Vtgs and their functions via application of novel vtg gene knock-out technology. This research will reveal fundamental molecular details of vitellogenesis and its relation to egg quality common to zebrafish and important farmed species. The host institution has ideal infrastructure and expertise available to the applicant to carry out the research, and the scientist-in-charge and his group are international leaders in this specific research area. The overall mobility program will endow the applicant with the scientific knowledge, the technical capabilities and other transferable professional skills, and the international network and visibility required for her to develop a superior research career of significant benefit to the European Research Area and associated countries.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biological morphology comparative morphology
- natural sciences biological sciences biochemistry biomolecules proteins proteomics
- medical and health sciences health sciences nutrition
- natural sciences biological sciences genetics genomes
- natural sciences biological sciences biochemistry biomolecules proteins enzymes
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2013-IEF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
75007 PARIS CEDEX 07
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.