Cel Within a densely interconnected network, selective communication can be achieved only if neuronal inputs and outputs are functionally segmented and if only one segment is selected for a given time and neural population. We focus here on this process in the primary motor cortex (M1) which projects to a variety of brain structures involved in motor generation and suppression as well as somatosensory perception. We propose to investigate what kind of information is sent to two of M1’s main target brain areas – the striatum and the somatosensory cortex by separate or partially overlapping neural subpopulations. To dissect the two pathways we will apply new optogenetic projection and stimulation strategies and combine them with controlled behavior and electrophysiological recordings conducted with advanced optoelectronic probes. The goal is to neurophysiologically characterize the two populations in a specially designed Go/NoGo task with sensorimotor component and understand their functional relevance for motor behavior. For causally defining the optimal stimulation frequencies for a specific task period, we will make use of real-time feedback by measuring ongoing oscillatory patterns and enhance or phase shift the synchronized activity in motor cortex and its targets. In particular, we will focus on beta and gamma band oscillations. While beta band activity has been mainly associated with the suppression of movements and with postural maintenance as well as sensorimotor integration and planning, elevated gamma band activity has been reported often during movement initiation and attention. We hypothesize that the best suited resonance frequencies differ between the two communication paths to S1 and striatum and that they might change across trial phases. Apart from the impact on basic science, finding out about the details of sensorimotor integration and the role of synchronization may lead to a better understanding of motor disorders, e.g. Parkinson’s disease. Program(-y) FP7-IDEAS-ERC - Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Temat(-y) ERC-SG-LS5 - ERC Starting Grant - Neurosciences and neural disorders Zaproszenie do składania wniosków ERC-2013-StG Zobacz inne projekty w ramach tego zaproszenia System finansowania ERC-SG - ERC Starting Grant Instytucja przyjmująca ALBERT-LUDWIGS-UNIVERSITAET FREIBURG Wkład UE € 1 498 890,00 Adres FAHNENBERGPLATZ 79098 Freiburg Niemcy Zobacz na mapie Region Baden-Württemberg Freiburg Freiburg im Breisgau, Stadtkreis Rodzaj działalności Higher or Secondary Education Establishments Kontakt administracyjny Christian Jaeger (Mr.) Kierownik naukowy Ilka Diester (Dr.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych Beneficjenci (1) Sortuj alfabetycznie Sortuj według wkładu UE Rozwiń wszystko Zwiń wszystko ALBERT-LUDWIGS-UNIVERSITAET FREIBURG Niemcy Wkład UE € 1 498 890,00 Adres FAHNENBERGPLATZ 79098 Freiburg Zobacz na mapie Region Baden-Württemberg Freiburg Freiburg im Breisgau, Stadtkreis Rodzaj działalności Higher or Secondary Education Establishments Kontakt administracyjny Christian Jaeger (Mr.) Kierownik naukowy Ilka Diester (Dr.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych