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Development of a non-invassive breath test for early diagnosis of tropical diseases

Development of a non-invassive breath test for early diagnosis of tropical diseases

Objective

This project aims at demonstrating the feasibility of a non-invasive, safe and patient-friendly methodology for on-site rapid diagnosis of tropical diseases. The proposed approach is based on breath samples analyses, which are easy to obtain and present no discomfort or risk for patients health. In this study will be enrolled patients with three different types of neglected tropical diseases (Hydatidosis, Leishmaniasis and Dengue) from different geographical locations (Europe, South America and Maghreb). Breath sampling will follow a standardised procedure. Analytical chemistry methods will be employed for the identification of the breath volatile biomarkers of these diseases. A pool of potential nanomaterials with high affinity towards the identified VOCs will be selected (e.g., gold nanoparticles, carbon nanotubes and semiconducting nanowires, either pristine or functionalised with selected hydrophobic organic molecules and/or bio-molecules). For maximising the possibility of success of our methodology, we will investigate the synergic effect of different advanced and complementary chemical sensing techniques: Mid-Infrared Quantum Cascade Laser spectroscopy and different types of Chemical Gas Sensors devices. These techniques are particularly attractive, since they can be miniaturised and are suitable for building on-site portable systems. Advanced pattern recognition algorithms will be employed for building discriminative models for the identification of the fingerprints of the different tropical diseases studied, and multisensors data fusion will be then applied for obtaining enhanced resulyts. A point of care prototype will be proposed on the basis of the results obtained and validated on-site.
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Coordinator

UPPSALA UNIVERSITET

Address

Von Kraemers Alle 4
751 05 Uppsala

Sweden

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 18 000

Participants (10)

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TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY

Israel

EU Contribution

€ 4 500

INSTITUTUL NATIONAL DE CERCETARE-DEZVOLTARE PENTRU METALE NEFEROASE SIRARE-IMNR

Romania

EU Contribution

€ 184 500

POLITECHNIKA GDANSKA

Poland

EU Contribution

€ 126 000

UNIVERSITAET ULM

Germany

EU Contribution

€ 198 000

MOLECULAR FINGERPRINT SWEDEN AB

Sweden

EU Contribution

€ 67 500

SITEX 45 SRL

Romania

EU Contribution

€ 202 500

JLM INNOVATION GMBH

Germany

EU Contribution

€ 121 500

UNIWERSYTECKIE CENTRUM MEDYCYNY MORSKIEJ I TROPIKALNEJ

Poland

EU Contribution

€ 63 000

UNIVERSITAT ROVIRA I VIRGILI

Spain

EU Contribution

€ 315 000

INSTITUTUL DE CHIMIE MACROMOLECULARA PETRU PONI

Romania

EU Contribution

€ 85 500

Partners (3)

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INSTITUT PASTEUR DE TUNIS

UNIVERSITE MOULAY ISMAIL

UNIVERSIDAD DE PAMPLONA

Project information

Grant agreement ID: 645758

Status

Closed project

  • Start date

    1 February 2015

  • End date

    31 January 2019

Funded under:

H2020-EU.1.3.3.

  • Overall budget:

    € 1 386 000

  • EU contribution

    € 1 386 000

Coordinated by:

UPPSALA UNIVERSITET

Sweden