Alzheimer Disease - gut connection

Deliverables

Websites, patent fillings, videos etc. (5)

Creation of website

see WP5 description

Workshop

see WP5 description

Mid-term press release

see WP5 description

Production of m-MOOCs

and at month 48 see WP5 description

Final press release

see WP5 description

Publications

Peer reviewed articles (27)

Native protein hydrogels by dynamic boronic acid chemistry

Author(s): Christiane Seidler, David Y.W. Ng, Tanja Weil
Published in: Tetrahedron, 73/33, 2017, Page(s) 4979-4987, ISSN 0040-4020
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.tet.2017.06.066

Complementarity of PALM and SOFI for super-resolution live-cell imaging of focal adhesions

Author(s): Hendrik Deschout, Tomas Lukes, Azat Sharipov, Daniel Szlag, Lely Feletti, Wim Vandenberg, Peter Dedecker, Johan Hofkens, Marcel Leutenegger, Theo Lasser, Aleksandra Radenovic
Published in: Nature Communications, 7, 2016, Page(s) 13693, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/ncomms13693

Spatiotemporally Controlled Release of Rho-Inhibiting C3 Toxin from a Protein-DNA Hybrid Hydrogel for Targeted Inhibition of Osteoclast Formation and Activity

Author(s): Jasmina Gačanin, Anna Kovtun, Stephan Fischer, Victoria Schwager, Johanna Quambusch, Seah Ling Kuan, Weina Liu, Felix Boldt, Chuang Li, Zhongqiang Yang, Dongsheng Liu, Yuzhou Wu, Tanja Weil, Holger Barth, Anita Ignatius
Published in: Advanced Healthcare Materials, 6/21, 2017, Page(s) 1700392, ISSN 2192-2640
Publisher: John Wiley and Sons Ltd
DOI: 10.1002/adhm.201700392

Methyltransferase-Directed Labeling of Biomolecules and its Applications

Author(s): Jochem Deen, Charlotte Vranken, Volker Leen, Robert K. Neely, Kris P. F. Janssen, Johan Hofkens
Published in: Angewandte Chemie International Edition, 56/19, 2017, Page(s) 5182-5200, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201608625

Reduced Fluorescent Protein Switching Fatigue by Binding-Induced Emissive State Stabilization

Author(s): Thijs Roebroek, Sam Duwé, Wim Vandenberg, Peter Dedecker
Published in: International Journal of Molecular Sciences, 18/10, 2017, Page(s) 2015, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms18092015

Live-cell monochromatic dual-label sub-diffraction microscopy by mt-pcSOFI

Author(s): S. Duwé, W. Vandenberg, P. Dedecker
Published in: Chem. Commun., 53/53, 2017, Page(s) 7242-7245, ISSN 1359-7345
Publisher: Royal Society of Chemistry
DOI: 10.1039/c7cc02344h

Combined multi-plane phase retrieval and super-resolution optical fluctuation imaging for 4D cell microscopy

Author(s): A. Descloux, K. S. Grußmayer, E. Bostan, T. Lukes, A. Bouwens, A. Sharipov, S. Geissbuehler, A.-L. Mahul-Mellier, H. A. Lashuel, M. Leutenegger, T. Lasser
Published in: Nature Photonics, 12/3, 2018, Page(s) 165-172, ISSN 1749-4885
Publisher: Nature Pub. Group
DOI: 10.1038/s41566-018-0109-4

Optical projection tomography for rapid whole mouse brain imaging

Author(s): David Nguyen, Paul J. Marchand, Arielle L. Planchette, Julia Nilsson, Miguel Sison, Jérôme Extermann, Antonio Lopez, Marcin Sylwestrzak, Jessica Sordet-Dessimoz, Anja Schmidt-Christensen, Dan Holmberg, Dimitri Van De Ville, Theo Lasser
Published in: Biomedical Optics Express, 8/12, 2017, Page(s) 5637, ISSN 2156-7085
Publisher: The Optical Society
DOI: 10.1364/boe.8.005637

Correcting for photodestruction in super-resolution optical fluctuation imaging

Author(s): Yves Peeters, Wim Vandenberg, Sam Duwé, Arno Bouwens, Tomáš Lukeš, Cyril Ruckebusch, Theo Lasser, Peter Dedecker
Published in: Scientific Reports, 7/1, 2017, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-017-09666-4

Quantifying protein densities on cell membranes using super-resolution optical fluctuation imaging

Author(s): Tomáš Lukeš, Daniela Glatzová, Zuzana Kvíčalová, Florian Levet, Aleš Benda, Sebastian Letschert, Markus Sauer, Tomáš Brdička, Theo Lasser, Marek Cebecauer
Published in: Nature Communications, 8/1, 2017, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-017-01857-x

Autonomous Ultrafast Self-Healing Hydrogels by pH-Responsive Functional Nanofiber Gelators as Cell Matrices

Author(s): Gačanin, J.; Hedrich, J.; Sieste, S.; Glasser, G.; Lieberwirth, I.; Schilling, C.; Fischer, S.; Barth, H.; Knoell, B.; Synatschke, C.; Weil, T.
Published in: Advanced Materials, 31, 2019, ISSN 0935-9648
Publisher: United Nations Industrial Developement Organization
DOI: 10.1002/adma.201805044

Lectin-Functionalized Composite Hydrogels for “Capture-and-Killing” of Carbapenem-Resistant Pseudomonas aeruginosa

Author(s): N. Bodenberger, D. Kubiczek, D. Halbgebauer, V. Rimola, S. Wiese, D. Mayer, A. A. Rodriguez Alfonso, L. Ständker, S. Stenger, F. Rosenau
Published in: Biomacromolecules, 19 (7), 2018, Page(s) 2472/2482, ISSN 1525-7797
Publisher: American Chemical Society
DOI: 10.1021/acs.biomac.8b00089

Go with the flow or solitary confinement: a look inside the single-cell toolbox for isolation of rare and uncultured microbes

Author(s): G. R. B. Huys, J. Raes
Published in: Current Opinion in Microbiology, Vol. 44, 2018, Page(s) 1/8, ISSN 1369-5274
Publisher: Elsevier BV
DOI: 10.1016/j.mib.2018.05.002

Orthogonally Stimulated Assembly/Disassembly of Depsi‐peptides by Rational Chemical Design

Author(s): M. Pieszka, A. M. Sobota, J. Gačanin, T. Weil, D. Y. W. Ng
Published in: ChemBioChem, 2019, ISSN 1439-7633
Publisher: Wiley-VCH
DOI: 10.1002/cbic.201800781m

Reduction of Abeta amyloid pathology in APPPS1 transgenic mice in the absence of gut microbiota

Author(s): T. Harach, N. Marungruang, N. Duthilleul, V. Cheatham, K. D. Mc Coy, G. Frisoni, J. J. Neher, F. Fåk, M. Jucker, T. Lasser, T. Bolmont
Published in: Scientific Reports, 7/1, 2017, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/srep41802

Integrated culturing, modeling and transcriptomics uncovers complex interactions and emergent behavior in a three-species synthetic gut community

Author(s): K. D’hoe, S. Vet, K. Faust, F. Moens, G. Falony, D. Gonze, V. Llorens-Rico, L. Gelens, J. Danckaert, L. De Vuyst and J. Raes
Published in: eLife, 2018, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.37090

Growth of engineered Pseudomonas putida KT2440 on glucose, xylose, and arabinose: Hemicellulose hydrolysates and their major sugars as sustainable carbon sources

Author(s): Wang, Y.; Horlamus, F.; Henkel, M.; Kovacic, F.; Schlaefle, S.; Hausmann, R.; Wittgens, A.; Rosenau, F.
Published in: GCB Bioenergy, 11, 2019, ISSN 1757-1693
Publisher: Wiley-VCH Verlag
DOI: 10.1111/gcbb.12590

Statistical parametric mapping of stimuli evoked changes in total blood flow velocity in the mouse cortex obtained with extended-focus optical coherence microscopy

Author(s): Shamaei, Vincent K.; Bouwens, Arno; Szlag, Daniel; Lasser, Theo; Nguyen, David; Extermann, Jérôme; Marchand, Paul J.; Bolmont, Tristan
Published in: Biomedical Optics Express, 1, 2017, Page(s) 1-15, ISSN 2156-7085
Publisher: The Optical Society
DOI: 10.1364/BOE.8.000001

Single Molecule Localization and Discrimination of DNA–Protein Complexes by Controlled Translocation Through Nanocapillaries

Author(s): Bulushev, Roman D.; Davis, Sebastian J.; Sebastian J Maerkl; Marion, Sanjin; Petrova, Ekaterina; Radenovic, Aleksandra
Published in: Nano Letters, 1, 2016, Page(s) 7882–7890, ISSN 1530-6984
Publisher: American Chemical Society
DOI: 10.1021/acs.nanolett.6b04165

Identifying microbial species by single-molecule DNA optical mapping and resampling statistics

Author(s): Arno Bouwens, Jochem Deen, Raffaele Vitale, Laurens D’Huys, Vince Goyvaerts, Adrien Descloux, Doortje Borrenberghs, Kristin Grussmayer, Tomas Lukes, Rafael Camacho, Jia Su, Cyril Ruckebusch, Theo Lasser, Dimitri Van De Ville, Johan Hofkens, Aleksandra Radenovic, Kris Pieter Frans Janssen
Published in: NAR Genomics and Bioinformatics, 2/1, 2020, ISSN 2631-9268
Publisher: Oxford University Press
DOI: 10.1093/nargab/lqz007

Parameter-free image resolution estimation based on decorrelation analysis

Author(s): A. Descloux, K. S. Grußmayer, A. Radenovic
Published in: Nature Methods, 16/9, 2019, Page(s) 918-924, ISSN 1548-7091
Publisher: Nature Publishing Group
DOI: 10.1038/s41592-019-0515-7

Supervised learning to quantify amyloidosis in whole brains of an Alzheimer’s disease mouse model acquired with optical projection tomography

Author(s): David Nguyen, Virginie Uhlmann, Arielle L. Planchette, Paul J. Marchand, Dimitri Van De Ville, Theo Lasser, Aleksandra Radenovic
Published in: Biomedical Optics Express, 10/6, 2019, Page(s) 3041, ISSN 2156-7085
Publisher: The Optical Society
DOI: 10.1364/boe.10.003041

Biomedical Applications of DNA‐Based Hydrogels

Author(s): Jasmina Gačanin, Christopher V. Synatschke, Tanja Weil
Published in: Advanced Functional Materials, 30/4, 2019, Page(s) 1906253, ISSN 1616-301X
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/adfm.201906253

Comparison of Three Xylose Pathways in Pseudomonas putida KT2440 for the Synthesis of Valuable Products

Author(s): Isabel Bator, Andreas Wittgens, Frank Rosenau, Till Tiso, Lars M. Blank
Published in: Frontiers in Bioengineering and Biotechnology, 7, 2020, ISSN 2296-4185
Publisher: Frontiers in Bioengineering and Biotechnology
DOI: 10.3389/fbioe.2019.00480

Fluorescent SAM analogues for methyltransferase based DNA labeling

Author(s): Vince Goyvaerts, Sven Van Snick, Laurens D'Huys, Raffaele Vitale, Milena Helmer Lauer, Su Wang, Volker Leen, Wim Dehaen, Johan Hofkens
Published in: Chemical Communications, 56/22, 2020, Page(s) 3317-3320, ISSN 1359-7345
Publisher: Royal Society of Chemistry
DOI: 10.1039/c9cc08938a

A Cerberus‐Inspired Anti‐Infective Multicomponent Gatekeeper Hydrogel against Infections with the Emerging “Superbug” Yeast Candida auris

Author(s): Dennis Kubiczek, Carolin Flaig, Heinz Raber, Steffen Dietz, Ann‐Kathrin Kissmann, Thomas Heerde, Nicholas Bodenberger, Andreas Wittgens, Melaine González‐Garcia, Fan Kang, Octavio L. Franco, Ludger Staendker, Anselmo J. Otero‐González, Paul Walther, Kay E. Gottschalk, Tanja Weil, Frank Rosenau
Published in: Macromolecular Bioscience, 20/4, 2020, Page(s) 2000005, ISSN 1616-5187
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/mabi.202000005

High-speed multiplane structured illumination microscopy of living cells using an image-splitting prism

Author(s): Adrien Descloux, Marcel Müller, Vytautas Navikas, Andreas Markwirth, Robin van den Eynde, Tomas Lukes, Wolfgang Hübner, Theo Lasser, Aleksandra Radenovic, Peter Dedecker, Thomas Huser
Published in: Nanophotonics, 9/1, 2019, Page(s) 143-148, ISSN 2192-8614
Publisher: De Gruyter
DOI: 10.1515/nanoph-2019-0346

Book chapters (2)

Aptamers as promising agents in diagnostic and therapeutic applications.

Author(s): D. Kubiczek, N. Bodenberger, F. Rosenau
Published in: Antimicrobial research: Novel bioknowledge and educational programs, 2017
Publisher: A. Méndez-Vilas, Ed.

Jelly Bombs–Hydrogels as Weapons against Microorganisms.

Author(s): N. Bodenberger, D. Kubiczek, D. Halbgebauer, C. Tanzer, N. Pfahler, F. Rosenau
Published in: Antimicrobial research: Novel bioknowledge and educational programs, 2017
Publisher: A. Méndez-Vilas, Ed.