Alzheimer Disease - gut connection

Informazioni relative al progetto

AD-gut

ID dell’accordo di sovvenzione: 686271

DOI

10.3030/686271

Progetto chiuso

Data della firma CE 29 Aprile 2016

Data di avvio 1 Aprile 2016

Data di completamento 31 Marzo 2020

Finanziato da

• INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies - Advanced materials

Costo totale

€ 7 686 620,00

Contributo UE

€ 5 092 886,25

Coordinato da

ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
Switzerland

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Websites, patent fillings, videos etc. (5)

Creation of website

see WP5 description

Workshop

see WP5 description

Mid-term press release

see WP5 description

Production of m-MOOCs

and at month 48 see WP5 description

Final press release

see WP5 description

Pubblicazioni

Peer reviewed articles (27)

Native protein hydrogels by dynamic boronic acid chemistry

Autori: Christiane Seidler, David Y.W. Ng, Tanja Weil
Pubblicato in: Tetrahedron, Numero 73/33, 2017, Pagina/e 4979-4987, ISSN 0040-4020
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.tet.2017.06.066

Complementarity of PALM and SOFI for super-resolution live-cell imaging of focal adhesions

Autori: Hendrik Deschout, Tomas Lukes, Azat Sharipov, Daniel Szlag, Lely Feletti, Wim Vandenberg, Peter Dedecker, Johan Hofkens, Marcel Leutenegger, Theo Lasser, Aleksandra Radenovic
Pubblicato in: Nature Communications, Numero 7, 2016, Pagina/e 13693, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/ncomms13693

Spatiotemporally Controlled Release of Rho-Inhibiting C3 Toxin from a Protein-DNA Hybrid Hydrogel for Targeted Inhibition of Osteoclast Formation and Activity

Autori: Jasmina Gačanin, Anna Kovtun, Stephan Fischer, Victoria Schwager, Johanna Quambusch, Seah Ling Kuan, Weina Liu, Felix Boldt, Chuang Li, Zhongqiang Yang, Dongsheng Liu, Yuzhou Wu, Tanja Weil, Holger Barth, Anita Ignatius
Pubblicato in: Advanced Healthcare Materials, Numero 6/21, 2017, Pagina/e 1700392, ISSN 2192-2640
Editore: John Wiley and Sons Ltd
DOI: 10.1002/adhm.201700392

Methyltransferase-Directed Labeling of Biomolecules and its Applications

Autori: Jochem Deen, Charlotte Vranken, Volker Leen, Robert K. Neely, Kris P. F. Janssen, Johan Hofkens
Pubblicato in: Angewandte Chemie International Edition, Numero 56/19, 2017, Pagina/e 5182-5200, ISSN 1433-7851
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201608625

Reduced Fluorescent Protein Switching Fatigue by Binding-Induced Emissive State Stabilization

Autori: Thijs Roebroek, Sam Duwé, Wim Vandenberg, Peter Dedecker
Pubblicato in: International Journal of Molecular Sciences, Numero 18/10, 2017, Pagina/e 2015, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms18092015

Live-cell monochromatic dual-label sub-diffraction microscopy by mt-pcSOFI

Autori: S. Duwé, W. Vandenberg, P. Dedecker
Pubblicato in: Chem. Commun., Numero 53/53, 2017, Pagina/e 7242-7245, ISSN 1359-7345
Editore: Royal Society of Chemistry
DOI: 10.1039/c7cc02344h

Combined multi-plane phase retrieval and super-resolution optical fluctuation imaging for 4D cell microscopy

Autori: A. Descloux, K. S. Grußmayer, E. Bostan, T. Lukes, A. Bouwens, A. Sharipov, S. Geissbuehler, A.-L. Mahul-Mellier, H. A. Lashuel, M. Leutenegger, T. Lasser
Pubblicato in: Nature Photonics, Numero 12/3, 2018, Pagina/e 165-172, ISSN 1749-4885
Editore: Nature Pub. Group
DOI: 10.1038/s41566-018-0109-4

Optical projection tomography for rapid whole mouse brain imaging

Autori: David Nguyen, Paul J. Marchand, Arielle L. Planchette, Julia Nilsson, Miguel Sison, Jérôme Extermann, Antonio Lopez, Marcin Sylwestrzak, Jessica Sordet-Dessimoz, Anja Schmidt-Christensen, Dan Holmberg, Dimitri Van De Ville, Theo Lasser
Pubblicato in: Biomedical Optics Express, Numero 8/12, 2017, Pagina/e 5637, ISSN 2156-7085
Editore: The Optical Society
DOI: 10.1364/boe.8.005637

Correcting for photodestruction in super-resolution optical fluctuation imaging

Autori: Yves Peeters, Wim Vandenberg, Sam Duwé, Arno Bouwens, Tomáš Lukeš, Cyril Ruckebusch, Theo Lasser, Peter Dedecker
Pubblicato in: Scientific Reports, Numero 7/1, 2017, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-017-09666-4

Quantifying protein densities on cell membranes using super-resolution optical fluctuation imaging

Autori: Tomáš Lukeš, Daniela Glatzová, Zuzana Kvíčalová, Florian Levet, Aleš Benda, Sebastian Letschert, Markus Sauer, Tomáš Brdička, Theo Lasser, Marek Cebecauer
Pubblicato in: Nature Communications, Numero 8/1, 2017, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-017-01857-x

Autonomous Ultrafast Self-Healing Hydrogels by pH-Responsive Functional Nanofiber Gelators as Cell Matrices

Autori: Gačanin, J.; Hedrich, J.; Sieste, S.; Glasser, G.; Lieberwirth, I.; Schilling, C.; Fischer, S.; Barth, H.; Knoell, B.; Synatschke, C.; Weil, T.
Pubblicato in: Advanced Materials, Numero 31, 2019, ISSN 0935-9648
Editore: United Nations Industrial Developement Organization
DOI: 10.1002/adma.201805044

Lectin-Functionalized Composite Hydrogels for “Capture-and-Killing” of Carbapenem-Resistant Pseudomonas aeruginosa

Autori: N. Bodenberger, D. Kubiczek, D. Halbgebauer, V. Rimola, S. Wiese, D. Mayer, A. A. Rodriguez Alfonso, L. Ständker, S. Stenger, F. Rosenau
Pubblicato in: Biomacromolecules, Numero 19 (7), 2018, Pagina/e 2472/2482, ISSN 1525-7797
Editore: American Chemical Society
DOI: 10.1021/acs.biomac.8b00089

Go with the flow or solitary confinement: a look inside the single-cell toolbox for isolation of rare and uncultured microbes

Autori: G. R. B. Huys, J. Raes
Pubblicato in: Current Opinion in Microbiology, Numero Vol. 44, 2018, Pagina/e 1/8, ISSN 1369-5274
Editore: Elsevier BV
DOI: 10.1016/j.mib.2018.05.002

Orthogonally Stimulated Assembly/Disassembly of Depsi‐peptides by Rational Chemical Design

Autori: M. Pieszka, A. M. Sobota, J. Gačanin, T. Weil, D. Y. W. Ng
Pubblicato in: ChemBioChem, 2019, ISSN 1439-7633
Editore: Wiley-VCH
DOI: 10.1002/cbic.201800781m

Reduction of Abeta amyloid pathology in APPPS1 transgenic mice in the absence of gut microbiota

Autori: T. Harach, N. Marungruang, N. Duthilleul, V. Cheatham, K. D. Mc Coy, G. Frisoni, J. J. Neher, F. Fåk, M. Jucker, T. Lasser, T. Bolmont
Pubblicato in: Scientific Reports, Numero 7/1, 2017, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/srep41802

Integrated culturing, modeling and transcriptomics uncovers complex interactions and emergent behavior in a three-species synthetic gut community

Autori: K. D’hoe, S. Vet, K. Faust, F. Moens, G. Falony, D. Gonze, V. Llorens-Rico, L. Gelens, J. Danckaert, L. De Vuyst and J. Raes
Pubblicato in: eLife, 2018, ISSN 2050-084X
Editore: eLife Sciences Publications
DOI: 10.7554/elife.37090

Growth of engineered Pseudomonas putida KT2440 on glucose, xylose, and arabinose: Hemicellulose hydrolysates and their major sugars as sustainable carbon sources

Autori: Wang, Y.; Horlamus, F.; Henkel, M.; Kovacic, F.; Schlaefle, S.; Hausmann, R.; Wittgens, A.; Rosenau, F.
Pubblicato in: GCB Bioenergy, Numero 11, 2019, ISSN 1757-1693
Editore: Wiley-VCH Verlag
DOI: 10.1111/gcbb.12590

Statistical parametric mapping of stimuli evoked changes in total blood flow velocity in the mouse cortex obtained with extended-focus optical coherence microscopy

Autori: Shamaei, Vincent K.; Bouwens, Arno; Szlag, Daniel; Lasser, Theo; Nguyen, David; Extermann, Jérôme; Marchand, Paul J.; Bolmont, Tristan
Pubblicato in: Biomedical Optics Express, Numero 1, 2017, Pagina/e 1-15, ISSN 2156-7085
Editore: The Optical Society
DOI: 10.1364/BOE.8.000001

Single Molecule Localization and Discrimination of DNA–Protein Complexes by Controlled Translocation Through Nanocapillaries

Autori: Bulushev, Roman D.; Davis, Sebastian J.; Sebastian J Maerkl; Marion, Sanjin; Petrova, Ekaterina; Radenovic, Aleksandra
Pubblicato in: Nano Letters, Numero 1, 2016, Pagina/e 7882–7890, ISSN 1530-6984
Editore: American Chemical Society
DOI: 10.1021/acs.nanolett.6b04165

Identifying microbial species by single-molecule DNA optical mapping and resampling statistics

Autori: Arno Bouwens, Jochem Deen, Raffaele Vitale, Laurens D’Huys, Vince Goyvaerts, Adrien Descloux, Doortje Borrenberghs, Kristin Grussmayer, Tomas Lukes, Rafael Camacho, Jia Su, Cyril Ruckebusch, Theo Lasser, Dimitri Van De Ville, Johan Hofkens, Aleksandra Radenovic, Kris Pieter Frans Janssen
Pubblicato in: NAR Genomics and Bioinformatics, Numero 2/1, 2020, ISSN 2631-9268
Editore: Oxford University Press
DOI: 10.1093/nargab/lqz007

Parameter-free image resolution estimation based on decorrelation analysis

Autori: A. Descloux, K. S. Grußmayer, A. Radenovic
Pubblicato in: Nature Methods, Numero 16/9, 2019, Pagina/e 918-924, ISSN 1548-7091
Editore: Nature Publishing Group
DOI: 10.1038/s41592-019-0515-7

Supervised learning to quantify amyloidosis in whole brains of an Alzheimer’s disease mouse model acquired with optical projection tomography

Autori: David Nguyen, Virginie Uhlmann, Arielle L. Planchette, Paul J. Marchand, Dimitri Van De Ville, Theo Lasser, Aleksandra Radenovic
Pubblicato in: Biomedical Optics Express, Numero 10/6, 2019, Pagina/e 3041, ISSN 2156-7085
Editore: The Optical Society
DOI: 10.1364/boe.10.003041

Biomedical Applications of DNA‐Based Hydrogels

Autori: Jasmina Gačanin, Christopher V. Synatschke, Tanja Weil
Pubblicato in: Advanced Functional Materials, Numero 30/4, 2019, Pagina/e 1906253, ISSN 1616-301X
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/adfm.201906253

Comparison of Three Xylose Pathways in Pseudomonas putida KT2440 for the Synthesis of Valuable Products

Autori: Isabel Bator, Andreas Wittgens, Frank Rosenau, Till Tiso, Lars M. Blank
Pubblicato in: Frontiers in Bioengineering and Biotechnology, Numero 7, 2020, ISSN 2296-4185
Editore: Frontiers in Bioengineering and Biotechnology
DOI: 10.3389/fbioe.2019.00480

Fluorescent SAM analogues for methyltransferase based DNA labeling

Autori: Vince Goyvaerts, Sven Van Snick, Laurens D'Huys, Raffaele Vitale, Milena Helmer Lauer, Su Wang, Volker Leen, Wim Dehaen, Johan Hofkens
Pubblicato in: Chemical Communications, Numero 56/22, 2020, Pagina/e 3317-3320, ISSN 1359-7345
Editore: Royal Society of Chemistry
DOI: 10.1039/c9cc08938a

A Cerberus‐Inspired Anti‐Infective Multicomponent Gatekeeper Hydrogel against Infections with the Emerging “Superbug” Yeast Candida auris

Autori: Dennis Kubiczek, Carolin Flaig, Heinz Raber, Steffen Dietz, Ann‐Kathrin Kissmann, Thomas Heerde, Nicholas Bodenberger, Andreas Wittgens, Melaine González‐Garcia, Fan Kang, Octavio L. Franco, Ludger Staendker, Anselmo J. Otero‐González, Paul Walther, Kay E. Gottschalk, Tanja Weil, Frank Rosenau
Pubblicato in: Macromolecular Bioscience, Numero 20/4, 2020, Pagina/e 2000005, ISSN 1616-5187
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/mabi.202000005

High-speed multiplane structured illumination microscopy of living cells using an image-splitting prism

Autori: Adrien Descloux, Marcel Müller, Vytautas Navikas, Andreas Markwirth, Robin van den Eynde, Tomas Lukes, Wolfgang Hübner, Theo Lasser, Aleksandra Radenovic, Peter Dedecker, Thomas Huser
Pubblicato in: Nanophotonics, Numero 9/1, 2019, Pagina/e 143-148, ISSN 2192-8614
Editore: De Gruyter
DOI: 10.1515/nanoph-2019-0346

Book chapters (2)

Aptamers as promising agents in diagnostic and therapeutic applications.

Autori: D. Kubiczek, N. Bodenberger, F. Rosenau
Pubblicato in: Antimicrobial research: Novel bioknowledge and educational programs, 2017
Editore: A. Méndez-Vilas, Ed.

Jelly Bombs–Hydrogels as Weapons against Microorganisms.

Autori: N. Bodenberger, D. Kubiczek, D. Halbgebauer, C. Tanzer, N. Pfahler, F. Rosenau
Pubblicato in: Antimicrobial research: Novel bioknowledge and educational programs, 2017
Editore: A. Méndez-Vilas, Ed.