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Imaging synaptic contributors to dementia

Publications

Nanoscale structure of amyloid-β plaques in Alzheimer’s disease

Author(s): Marta Querol-Vilaseca, Martí Colom-Cadena, Jordi Pegueroles, Raúl Nuñez-Llaves, Joan Luque-Cabecerans, Laia Muñoz-Llahuna, Jordi Andilla, Olivia Belbin, Tara L. Spires-Jones, Ellen Gelpi, Jordi Clarimon, Pablo Loza-Alvarez, Juan Fortea, Alberto Lleó
Published in: Scientific Reports, Issue 9/1, 2019, ISSN 2045-2322
DOI: 10.1038/s41598-019-41443-3

Invited Review: APOE at the interface of inflammation, neurodegeneration and pathological protein spread in Alzheimer's disease

Author(s): M. Tzioras, C. Davies, A. Newman, R. Jackson, T. Spires‐Jones
Published in: Neuropathology and Applied Neurobiology, Issue 45/4, 2018, Page(s) 327-346, ISSN 0305-1846
DOI: 10.1111/nan.12529

Synaptic phosphorylated α-synuclein in dementia with Lewy bodies

Author(s): Martí Colom-Cadena, Jordi Pegueroles, Abigail G Herrmann, Christopher M Henstridge, Laia Muñoz, Marta Querol-Vilaseca, Carla San Martín-Paniello, Joan Luque-Cabecerans, Jordi Clarimon, Olivia Belbin, Raúl Núñez-Llaves, Rafael Blesa, Colin Smith, Chris-Anne McKenzie, Matthew P Frosch, Allyson Roe, Juan Fortea, Jordi Andilla, Pablo Loza-Alvarez, Ellen Gelpi, Bradley T Hyman, Tara L Spires-Jone
Published in: Brain, Issue 140/12, 2017, Page(s) 3204-3214, ISSN 0006-8950
DOI: 10.1093/brain/awx275

Clusterin accumulates in synapses in Alzheimer’s disease and is increased in apolipoprotein E4 carriers

Author(s): Rosemary J Jackson, Jamie Rose, Jane Tulloch, Chris Henstridge, Colin Smith, Tara L Spires-Jones
Published in: Brain Communications, 2019, ISSN 2632-1297
DOI: 10.1093/braincomms/fcz003

Human Brain-Derived Aβ Oligomers Bind to Synapses and Disrupt Synaptic Activity in a Manner That Requires APP

Author(s): Zemin Wang, Rosemary J. Jackson, Wei Hong, Walter M. Taylor, Grant T. Corbett, Arturo Moreno, Wen Liu, Shaomin Li, Matthew P. Frosch, Inna Slutsky, Tracy L. Young-Pearse, Tara L. Spires-Jones, Dominic M. Walsh
Published in: The Journal of Neuroscience, Issue 37/49, 2017, Page(s) 11947-11966, ISSN 0270-6474
DOI: 10.1523/jneurosci.2009-17.2017

Synaptogyrin-3 Mediates Presynaptic Dysfunction Induced by Tau

Author(s): Joseph McInnes, Keimpe Wierda, An Snellinx, Laura Bounti, Yu-Chun Wang, Ilie-Cosmin Stancu, Nuno Apóstolo, Kris Gevaert, Ilse Dewachter, Tara L. Spires-Jones, Bart De Strooper, Joris De Wit, Lujia Zhou, Patrik Verstreken
Published in: Neuron, Issue 97/4, 2018, Page(s) 823-835.e8, ISSN 0896-6273
DOI: 10.1016/j.neuron.2018.01.022

Interactions of pathological proteins in neurodegenerative diseases

Author(s): Tara L. Spires-Jones, Johannes Attems, Dietmar Rudolf Thal
Published in: Acta Neuropathologica, Issue 134/2, 2017, Page(s) 187-205, ISSN 0001-6322
DOI: 10.1007/s00401-017-1709-7

TDP-43 Depletion in Microglia Promotes Amyloid Clearance but Also Induces Synapse Loss

Author(s): Rosa C. Paolicelli, Ali Jawaid, Christopher M. Henstridge, Andrea Valeri, Mario Merlini, John L. Robinson, Edward B. Lee, Jamie Rose, Stanley Appel, Virginia M.-Y. Lee, John Q. Trojanowski, Tara Spires-Jones, Paul E. Schulz, Lawrence Rajendran
Published in: Neuron, Issue 95/2, 2017, Page(s) 297-308.e6, ISSN 0896-6273
DOI: 10.1016/j.neuron.2017.05.037

Synapse loss in the prefrontal cortex is associated with cognitive decline in amyotrophic lateral sclerosis

Author(s): Christopher M. Henstridge, Dimitrios I. Sideris, Emily Carroll, Sanziana Rotariu, Sally Salomonsson, Makis Tzioras, Chris-Anne McKenzie, Colin Smith, Christine A. F. von Arnim, Albert C. Ludolph, Dorothée Lulé, Danielle Leighton, Jon Warner, Elaine Cleary, Judith Newton, Robert Swingler, Siddharthan Chandran, Thomas H. Gillingwater, Sharon Abrahams, Tara L. Spires-Jones
Published in: Acta Neuropathologica, Issue 135/2, 2018, Page(s) 213-226, ISSN 0001-6322
DOI: 10.1007/s00401-017-1797-4

Antidiabetic Polypill Improves Central Pathology and Cognitive Impairment in a Mixed Model of Alzheimer’s Disease and Type 2 Diabetes

Author(s): Carmen Infante-Garcia, Juan Jose Ramos-Rodriguez, Carmen Hierro-Bujalance, Esperanza Ortegon, Eleanor Pickett, Rosemary Jackson, Fernando Hernandez-Pacho, Tara Spires-Jones, Monica Garcia-Alloza
Published in: Molecular Neurobiology, Issue 55/7, 2018, Page(s) 6130-6144, ISSN 0893-7648
DOI: 10.1007/s12035-017-0825-7

Spread of tau down neural circuits precedes synapse and neuronal loss in the rTgTauEC mouse model of early Alzheimer's disease

Author(s): Eleanor K. Pickett, Christopher M. Henstridge, Elizabeth Allison, Rose Pitstick, Amy Pooler, Susanne Wegmann, George Carlson, Bradley T. Hyman, Tara L. Spires-Jones
Published in: Synapse, Issue 71/6, 2017, Page(s) e21965, ISSN 0887-4476
DOI: 10.1002/syn.21965

Beyond the neuron–cellular interactions early in Alzheimer disease pathogenesis

Author(s): Christopher M. Henstridge, Bradley T. Hyman, Tara L. Spires-Jones
Published in: Nature Reviews Neuroscience, Issue 20/2, 2019, Page(s) 94-108, ISSN 1471-003X
DOI: 10.1038/s41583-018-0113-1

Region-specific depletion of synaptic mitochondria in the brains of patients with Alzheimer’s disease

Author(s): Eleanor K. Pickett, Jamie Rose, Caoimhe McCrory, Chris-Anne McKenzie, Declan King, Colin Smith, Thomas H. Gillingwater, Christopher M. Henstridge, Tara L. Spires-Jones
Published in: Acta Neuropathologica, Issue 136/5, 2018, Page(s) 747-757, ISSN 0001-6322
DOI: 10.1007/s00401-018-1903-2

sAPPβ and sAPPα increase structural complexity and E/I input ratio in primary hippocampal neurons and alter Ca 2+ homeostasis and CREB1-signaling

Author(s): Raphael Hesse, Bjoern von Einem, Franziska Wagner, Patricia Bott, Daniel Schwanzar, Rosemary J. Jackson, Karl Josef Föhr, Ludwig Lausser, Katja S. Kroker, Christian Proepper, Paul Walther, Hans A. Kestler, Tara L. Spires-Jones, Tobias Boeckers, Holger Rosenbrock, Christine A.F. von Arnim
Published in: Experimental Neurology, Issue 304, 2018, Page(s) 1-13, ISSN 0014-4886
DOI: 10.1016/j.expneurol.2018.02.010