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Risk assessment of plaque rupture and future cardiovascular events (CVENT) by multi-spectral photoacoustic imaging

Risk assessment of plaque rupture and future cardiovascular events (CVENT) by multi-spectral photoacoustic imaging

Objective

Cardiovascular disease (CVD), more specifically, vulnerable plaque rupture, remains the major cause of death for people at middle age. The CVENT consortium will revolutionize screening, diagnosis and monitoring of CVD by means of a compact photoacoustic imaging (PAI) system for vulnerable plaque imaging.
In the carotid arteries feeding the brain, vulnerable plaque rupture initiates cerebrovascular ischemic attacks. The state-of-the-art decision-making approach for a high-risk surgical intervention to avoid plaque rupture is based on stenosis severity alone, measured with ultrasound (US) imaging. However, this does not distinguish between vulnerable (rupture-prone) and stable (harmless) plaques, leading to severe overtreatment. Consequently, there is a worldwide unmet and urgent clinical need for functional information to enable in-depth diagnosis of carotid plaque vulnerability, avoiding cardiovascular events (CVENT) and reducing overtreatment risk.
The objective of the CVENT consortium is the development of a portable multimodal and multiwavelength PAI system with a 3 cm imaging depth, for diagnosis and monitoring of carotid plaque vulnerability. The combination of high optical contrast of PAI and the high resolution of US will be used to identify plaque vulnerability markers, typically lipid pools and intra-plaque haemorrhage. Improved diagnosis of carotid plaque vulnerability will lead to a significant reduction in CVD-related disability and mortality. Simultaneously, by stratifying patients into high and low risk groups, overtreatment is reduced, leading to better allocation of healthcare funds.
The CVENT consortium unites leading research groups, clinicians, industrial partners, and their expertise on R&D and a focus on exploitation, creating a breakthrough in carotid plaque vulnerability diagnosis. CVENT will bring together leading experts in the field of CVD, functional US imaging and PAI, introducing clinically applied PAI into the vascular medical arena.
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Coordinator

ESAOTE EUROPE B.V.

Address

Philipsweg 1
6227aj Maastricht

Netherlands

Activity type

Private for-profit entities (excluding Higher or Secondary Education Establishments)

EU Contribution

€ 840 000

Participants (9)

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TECHNISCHE UNIVERSITEIT EINDHOVEN

Netherlands

EU Contribution

€ 555 428,75

RUHR-UNIVERSITAET BOCHUM

Germany

EU Contribution

€ 399 000

UNIVERSITE PARIS DESCARTES

France

EU Contribution

€ 399 000

LUMIBIRD

France

EU Contribution

€ 865 000

UNIVERSITEIT TWENTE

Netherlands

EU Contribution

€ 413 038,75

UNIVERSITAET BERN

Switzerland

BRIGHTLOOP SAS

France

EU Contribution

€ 299 916,25

SILIOS TECHNOLOGIES SA

France

EU Contribution

€ 265 656,25

TP21 GMBH

Germany

EU Contribution

€ 223 750

Project information

Grant agreement ID: 731771

Status

Ongoing project

  • Start date

    1 November 2016

  • End date

    30 April 2020

Funded under:

H2020-EU.2.1.1.

  • Overall budget:

    € 4 697 377,50

  • EU contribution

    € 4 260 790

Coordinated by:

ESAOTE EUROPE B.V.

Netherlands