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Assessing risk and progression of prediabetes and type 2 diabetes to enable disease modification - Sofia ref.: 115881

Deliverables

Integrated model of pre-diabetes and T2D populations

Integrated model of prediabetes and T2D populations

Economic model of pre-diabetes populations

Economic model of pre-diabetes populations

Health technology assessment of new biomarker technologies at the early stages of development and dissemination

Health technology assessment of new biomarker technologies at the early stages of development and dissemination.

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Publications

Elevated circulating follistatin associates with an increased risk of type 2 diabetes

Author(s): Wu, Chuanyan; Borné, Yan; Gao, Rui; López Rodriguez, Maykel; Roell, William C.; Wilson, Jonathan M.; Regmi, Ajit; Luan, Cheng; Aly, Dina Mansour; Peter, Andreas; Machann, Jürgen; Staiger, Harald; Fritsche, Andreas; Birkenfeld, Andreas L.; Tao, Rongya; Wagner, Robert; Canouil, Mickaël; Hong, Mun-Gwan; Schwenk, Jochen M.; Ahlqvist, Emma; Kaikkonen, Minna U.; Nilsson, Peter; Shore, Angela C.; Kha
Published in: Nature Communications, 12, 2021, Page(s) 6486, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-26536-w

An investigation of causal relationships between prediabetes and vascular complications

Author(s): Mutie, Pascal M.; Pomares-Millan, Hugo; Atabaki-Pasdar, Naeimeh; Jordan, Nina; Adams, Rachel; Daly, Nicole L.; Tajes, Juan Fernandes; Giordano, Giuseppe N.; Franks, Paul W.
Published in: Nature Communications, 11, 2020, Page(s) 4592, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-18386-9

3D FIB-SEM reconstruction of microtubule–organelle interaction in whole primary mouse β cells

Author(s): Müller, Andreas; Schmidt, Deborah; Xu, C. Shan; Pang, Song; D’Costa, Joyson Verner; Kretschmar, Susanne; Münster, Carla; Kurth, Thomas; Jug, Florian; Weigert, Martin; Hess, Harald F.; Solimena, Michele
Published in: Journal of Cell Biology, 220, 2021, Page(s) 0021-9525, 1540-8140, ISSN 0021-9525
Publisher: Rockefeller University Press
DOI: 10.1083/jcb.202010039

Prediction of mortality and major cardiovascular complications in type 2 diabetes: External validation of UK Prospective Diabetes Study outcomes model version 2 in two European observational cohorts

Author(s): Eva Pagano, Stefan R. A. Konings, Daniela Di Cuonzo, Rosalba Rosato, Graziella Bruno, Amber A. Heijden, Joline Beulens, Roderick Slieker, Jose Leal, Talitha L. Feenstra
Published in: Diabetes, Obesity and Metabolism, 2021, ISSN 1462-8902
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/dom.14311

Recent Insights Into Mechanisms of β-Cell Lipo- and Glucolipotoxicity in Type 2 Diabetes

Author(s): Lytrivi, Maria; Castell, Anne-Laure; Poitout, Vincent; Cnop, Miriam
Published in: Journal of Molecular Biology, 432, 2020, Page(s) 1514-1534, ISSN 0022-2836
Publisher: Academic Press
DOI: 10.1016/j.jmb.2019.09.016

Evaluating the Ability of Economic Models of Diabetes to Simulate New Cardiovascular Outcomes Trials: A Report on the Ninth Mount Hood Diabetes Challenge

Author(s): Si, Lei; Willis, Michael S.; Asseburg, Christian; Nilsson, Andreas; Tew, Michelle; Clarke, Philip M.; Lamotte, Mark; Ramos, Mafalda; Shao, Hui; Shi, Lizheng; Zhang, Ping; McEwan, Phil; Ye, Wen; Herman, William H.; Kuo, Shihchen; Isaman, Deanna J.; Schramm, Wendelin; Sailer, Fabian; Brennan, Alan; Pollard, Daniel; Smolen, Harry J.; Leal, José; Gray, Alastair; Patel, Rishi; Feenstra, Talitha; Palme
Published in: Value in Health, 23, 2020, Page(s) 1163-1170, ISSN 1098-3015
Publisher: Blackwell Publishing Inc.
DOI: 10.1016/j.jval.2020.04.1832

Intravital imaging of islet Ca2+ dynamics reveals enhanced β cell connectivity after bariatric surgery in mice

Author(s): Elina Akalestou, Kinga Suba, Livia Lopez-Noriega, Eleni Georgiadou, Pauline Chabosseau, Alasdair Gallie, Asger Wretlind, Cristina Legido-Quigley, Isabelle Leclerc, Victoria Salem, Guy A. Rutter
Published in: Nature Communications, 12/1, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-25423-8

Regulated expression and function of the GABAB receptor in human pancreatic beta cell line and islets

Author(s): Latif Rachdi, Alicia Maugein, Severine Pechberty, Mathieu Armanet, Juliette Hamroune, Philippe Ravassard, Stefano Marullo, Olivier Albagli, Raphael Scharfmann
Published in: Scientific Reports, 10/1, 2020, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-020-69758-6

Pathological β-Cell Endoplasmic Reticulum Stress in Type 2 Diabetes: Current Evidence

Author(s): Neha Shrestha, Elisa De Franco, Peter Arvan, Miriam Cnop
Published in: Frontiers in Endocrinology, 12, 2021, ISSN 1664-2392
Publisher: frontiers
DOI: 10.3389/fendo.2021.650158

Sequential in vivo labeling of insulin secretory granule pools in INS - SNAP transgenic pigs

Author(s): Elisabeth Kemter, Andreas Müller, Martin Neukam, Anna Ivanova, Nikolai Klymiuk, Simone Renner, Kaiyuan Yang, Johannes Broichhagen, Mayuko Kurome, Valeri Zakhartchenko, Barbara Kessler, Klaus-Peter Knoch, Marc Bickle, Barbara Ludwig, Kai Johnsson, Heiko Lickert, Thomas Kurth, Eckhard Wolf, Michele Solimena
Published in: Proceedings of the National Academy of Sciences, 118/37, 2021, Page(s) e2107665118, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2107665118

Metabolic and functional heterogeneity in pancreatic β cells

Author(s): Gabriela da Silva Xavier; Guy A. Rutter
Published in: Journal of Molecular Biology, 2020, ISSN 0022-2836
Publisher: Academic Press
DOI: 10.1016/j.jmb.2019.08.005

Multi-omics profiling of living human pancreatic islet donors reveals heterogeneous beta cell trajectories towards type 2 diabetes

Author(s): Leonore Wigger, Marko Barovic, Andreas-David Brunner, Flavia Marzetta, Eyke Schöniger, Florence Mehl, Nicole Kipke, Daniela Friedland, Frederic Burdet, Camille Kessler, Mathias Lesche, Bernard Thorens, Ezio Bonifacio, Cristina Legido-Quigley, Pierre Barbier Saint Hilaire, Philippe Delerive, Andreas Dahl, Christian Klose, Mathias J. Gerl, Kai Simons, Daniela Aust, Jürgen Weitz, Marius Distler, An
Published in: Nature Metabolism, 3/7, 2021, Page(s) 1017-1031, ISSN 2522-5812
Publisher: Nature
DOI: 10.1038/s42255-021-00420-9

Persistent or Transient Human β Cell Dysfunction Induced by Metabolic Stress: Specific Signatures and Shared Gene Expression with Type 2 Diabetes

Author(s): Lorella Marselli, Anthony Piron, Mara Suleiman, Maikel L. Colli, Xiaoyan Yi, Amna Khamis, Gaelle R. Carrat, Guy A. Rutter, Marco Bugliani, Laura Giusti, Maurizio Ronci, Mark Ibberson, Jean-Valery Turatsinze, Ugo Boggi, Paolo De Simone, Vincenzo De Tata, Miguel Lopes, Daniela Nasteska, Carmela De Luca, Marta Tesi, Emanuele Bosi, Pratibha Singh, Daniela Campani, Anke M. Schulte, Michele Solimena, Pe
Published in: Cell Reports, 33/9, 2020, Page(s) 108466, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2020.108466

Glucocorticoid Metabolism in Obesity and Following Weight Loss.

Author(s): Elina Akalestou; Laurent Genser; Laurent Genser; Guy A. Rutter
Published in: Frontiers in Endocrinology, 12, 2020, ISSN 1664-2392
Publisher: Frontiers Media
DOI: 10.3389/fendo.2020.00059

Combined transcriptome and proteome profiling of the pancreatic β-cell response to palmitate unveils key pathways of β-cell lipotoxicity

Author(s): Lytrivi, Maria; Ghaddar, Kassem; Lopes, Miguel; Rosengren, Victoria; Piron, Anthony; Yi, Xiaoyan; Johansson, Henrik; Lehtiö, Janne; Igoillo-Esteve, Mariana; Cunha, Daniel A.; Marselli, Lorella; Marchetti, Piero; Ortsäter, Henrik; Eizirik, Decio L.; Cnop, Miriam
Published in: BMC Genomics, 2020, ISSN 1471-2164
Publisher: BioMed Central
DOI: 10.1186/s12864-020-07003-0

A surrogate of Roux-en-Y gastric bypass (the enterogastro anastomosis surgery) regulates multiple beta-cell pathways during resolution of diabetes in ob/ob mice

Author(s): Chloé Amouyal, Julien Castel, Claudiane Guay, Amélie Lacombe, Jessica Denom, Stéphanie Migrenne-Li, Christine Rouault, Florian Marquet, Eleni Georgiadou, Theodoros Stylianides, Serge Luquet, Hervé Le Stunff, Raphael Scharfmann, Karine Clément, Guy A. Rutter, Olivier Taboureau, Christophe Magnan, Romano Regazzi, Fabrizio Andreelli
Published in: EBioMedicine, 58, 2020, Page(s) 102895, ISSN 2352-3964
Publisher: Elsevier BV
DOI: 10.1016/j.ebiom.2020.102895

Metabolically phenotyped pancreatectomized patients as living donors for the study of islets in health and diabetes

Author(s): Marko Barovic, Marius Distler, Eyke Schöniger, Nicole Radisch, Daniela Aust, Jürgen Weitz, Mark Ibberson, Anke M. Schulte, Michele Solimena
Published in: Molecular Metabolism, 27, 2019, Page(s) S1-S6, ISSN 2212-8778
Publisher: Elsevier GmbH
DOI: 10.1016/j.molmet.2019.06.006

Disconnect between signalling potency and in vivo efficacy of pharmacokinetically optimised biased glucagon-like peptide-1 receptor agonists

Author(s): Maria Lucey, Philip Pickford, Stavroula Bitsi, James Minnion, Jan Ungewiss, Katja Schoeneberg, Guy A. Rutter, Stephen R. Bloom, Alejandra Tomas, Ben Jones
Published in: Molecular Metabolism, 37, 2020, Page(s) 100991, ISSN 2212-8778
Publisher: Elsevier GmbH
DOI: 10.1016/j.molmet.2020.100991

Mechanisms of Weight Loss After Obesity Surgery

Author(s): Elina Akalestou, Alexander D Miras, Guy A Rutter, Carel W le Roux
Published in: Endocrine Reviews, 2021, ISSN 0163-769X
Publisher: The Endocrine Society
DOI: 10.1210/endrev/bnab022

Transcription factors that shape the mammalian pancreas

Author(s): Jennings, Rachel E.; Scharfmann, Raphael; Staels, Willem
Published in: Diabetologia, 63, 2020, Page(s) 1974-1980, ISSN 0012-186X
Publisher: Springer Verlag
DOI: 10.1007/s00125-020-05161-0

Plasma triacylglycerols are biomarkers of ß-cell function in mice and humans

Author(s): Ana Rodríguez Sánchez-Archidona, Céline Cruciani-Guglielmacci, Clara Roujeau, Leonore Wigger, Justine Lallement, Jessica Denom, Marko Barovic, Nadim Kassis, Florence Mehl, Jurgen Weitz, Marius Distler, Christian Klose, Kai Simons, Mark Ibberson, Michele Solimena, Christophe Magnan, Bernard Thorens
Published in: Molecular Metabolism, 2021, Page(s) 101355, ISSN 2212-8778
Publisher: Elsevier GmbH
DOI: 10.1016/j.molmet.2021.101355

Visit-to-visit variability of glycemia and vascular complications: the Hoorn Diabetes Care System cohort

Author(s): Roderick C. Slieker, Amber A. W. H. van der Heijden, Giel Nijpels, Petra J. M. Elders, Leen M. ’t Hart, Joline W. J. Beulens
Published in: Cardiovascular Diabetology, 18/1, 2019, ISSN 1475-2840
Publisher: BioMed Central
DOI: 10.1186/s12933-019-0975-1

Benchmarking the Cost-Effectiveness of Interventions Delaying Diabetes: A Simulation Study Based on NAVIGATOR Data

Author(s): Jose Leal, Shelby D. Reed, Rishi Patel, Oliver Rivero-Arias, Yanhong Li, Kevin A. Schulman, Robert M. Califf, Rury R. Holman, Alastair M. Gray
Published in: Diabetes Care, 43/10, 2020, Page(s) 2485-2492, ISSN 0149-5992
Publisher: American Diabetes Association
DOI: 10.2337/dc20-0717

Integration of single-cell datasets reveals novel transcriptomic signatures of β-cells in human type 2 diabetes

Author(s): Bosi, Emanuele; Marselli, Lorella; De Luca, Carmela; Suleiman, Mara; Tesi, Marta; Ibberson, Mark; Eizirik, Decio L.; Cnop, Miriam; Marchetti, Piero
Published in: NAR genomics and bioinformatics, 2, 2020, Page(s) lqaa097, ISSN 2631-9268
Publisher: Oxford University Press
DOI: 10.1093/nargab/lqaa097

The pore-forming subunit MCU of the mitochondrial Ca2+ uniporter is required for normal glucose-stimulated insulin secretion in vitro and in vivo in mice

Author(s): Georgiadou, Eleni; Haythorne, Elizabeth; Dickerson, Matthew T.; Lopez-Noriega, Livia; Pullen, Timothy J.; da Silva Xavier, Gabriela; Davis, Samuel P. X.; Martinez-Sanchez, Aida; Semplici, Francesca; Rizzuto, Rosario; McGinty, James A.; French, Paul M.; Cane, Matthew C.; Jacobson, David A.; Leclerc, Isabelle; Rutter, Guy A.
Published in: Diabetologia, 63, 2020, Page(s) 1368-1381, ISSN 0012-186X
Publisher: Springer Verlag
DOI: 10.1007/s00125-020-05148-x

The Influence of Peptide Context on Signaling and Trafficking of Glucagon-like Peptide-1 Receptor Biased Agonists

Author(s): Zijian Fang; Shiqian Chen; Philip Pickford; Johannes Broichhagen; David J. Hodson; David J. Hodson; Ivan R. Corrêa; Sunil Kumar; Frederik Görlitz; Christopher Dunsby; Paul M. W. French; Guy A. Rutter; Tricia Tan; Stephen R. Bloom; Alejandra Tomas; Ben Jones
Published in: ACS Pharmacol Transl Sci, 16, 2020, ISSN 2575-9108
Publisher: ACS Publications
DOI: 10.1021/acsptsci.0c00022

Pancreatic β-cells in type 1 and type 2 diabetes mellitus: different pathways to failure

Author(s): Décio L. Eizirik, Lorenzo Pasquali, Miriam Cnop
Published in: Nature Reviews Endocrinology, 16/7, 2020, Page(s) 349-362, ISSN 1759-5029
Publisher: Nature Publishing Group
DOI: 10.1038/s41574-020-0355-7

Performance of the UKPDS Outcomes Model for Prediction of Myocardial Infarction and Stroke in the ADDITION-Europe Trial Cohort

Author(s): Libo Tao, Edward C.F. Wilson, Simon J. Griffin, Rebecca K. Simmons
Published in: Value in Health, 16/6, 2013, Page(s) 1074-1080, ISSN 1098-3015
Publisher: Blackwell Publishing Inc.
DOI: 10.1016/j.jval.2013.06.001

Long Non-Coding RNAs as Key Modulators of Pancreatic β-Cell Mass and Function

Author(s): Livia López–Noriega, Guy A. Rutter
Published in: Frontiers in Endocrinology, 11, 2021, ISSN 1664-2392
Publisher: Frontiers in endocrinology
DOI: 10.3389/fendo.2020.610213

Estimating risk factor progression equations for the UKPDS Outcomes Model 2 (UKPDS 90)

Author(s): Jose Leal, Maria Alva, Vanessa Gregory, Alison Hayes, Borislava Mihaylova, Alastair M. Gray, Rury R. Holman, Philip Clarke
Published in: Diabetic Medicine, 38/10, 2021, ISSN 0742-3071
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/dme.14656

Détection cérébrale du glucose et homéostasie du glucose

Author(s): Bernard Thorens, Gwenaël Labouèbe
Published in: Médecine des Maladies Métaboliques, 15/5, 2021, Page(s) 518-525, ISSN 1957-2557
Publisher: Elsevier Masson
DOI: 10.1016/j.mmm.2021.05.004

Glucocorticoid Metabolism in Obesity and Following Weight Loss.

Author(s): Elina Akalestou; Laurent Genser; Laurent Genser; Guy A. Rutter
Published in: Frontiers in Endocrinology, 12, 2020, ISSN 1664-2392
Publisher: Frontiers Media
DOI: 10.3389/fendo.2020.00059

A direct look at the dysfunction and pathology of the β cells in human type 2 diabetes

Author(s): Marchetti, Piero; Suleiman, Mara; De Luca, Carmela; Baronti, Walter; Bosi, Emanuele; Tesi, Marta; Marselli, Lorella
Published in: Seminars in Cell & Developmental Biology, 103, 2021, Page(s) 83-93, ISSN 1084-9521
Publisher: Academic Press
DOI: 10.1016/j.semcdb.2020.04.005

Chromatin 3D interaction analysis of the STARD10 locus unveils FCHSD2 as a regulator of insulin secretion

Author(s): Ming Hu, Inês Cebola, Gaelle Carrat, Shuying Jiang, Sameena Nawaz, Amna Khamis, Mickaël Canouil, Philippe Froguel, Anke Schulte, Michele Solimena, Mark Ibberson, Piero Marchetti, Fabian L. Cardenas-Diaz, Paul J. Gadue, Benoit Hastoy, Leonardo Almeida-Souza, Harvey McMahon, Guy A. Rutter
Published in: Cell Reports, 34/5, 2021, Page(s) 108703, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2021.108703

Computer simulation models of pre-diabetes populations: a systematic review protocol

Author(s): Jose Leal, Waqar Khurshid, Eva Pagano, Talitha Feenstra
Published in: BMJ Open, 7/10, 2017, Page(s) e014954, ISSN 2044-6055
Publisher: BMJ Publishing Group
DOI: 10.1136/bmjopen-2016-014954

Painting a new picture of personalised medicine for diabetes

Author(s): Mark I. McCarthy
Published in: Diabetologia, 60/5, 2017, Page(s) 793-799, ISSN 0012-186X
Publisher: Springer Verlag
DOI: 10.1007/s00125-017-4210-x

Lifestyle and precision diabetes medicine: will genomics help optimise the prediction, prevention and treatment of type 2 diabetes through lifestyle therapy?

Author(s): Paul W Franks, Alaitz Poveda
Published in: Diabetologia, 60/5, 2017, Page(s) 784-792, ISSN 0012-186X
Publisher: Springer Verlag
DOI: 10.1007/s00125-017-4207-5

HbA1c is associated with altered expression in blood of cell cycle- and immune response-related genes

Author(s): Roderick C. Slieker, Amber A. W. A. van der Heijden, Nienke van Leeuwen, Hailiang Mei, Giel Nijpels, Joline W. J. Beulens, Leen M. ’t Hart
Published in: Diabetologia, 61/1, 2018, Page(s) 138-146, ISSN 0012-186X
Publisher: Springer Verlag
DOI: 10.1007/s00125-017-4467-0

MondoA Is an Essential Glucose-Responsive Transcription Factor in Human Pancreatic β-Cells

Author(s): Paul Richards, Latif Rachdi, Masaya Oshima, Piero Marchetti, Marco Bugliani, Mathieu Armanet, Catherine Postic, Sandra Guilmeau, Raphael Scharfmann
Published in: Diabetes, 67/3, 2018, Page(s) 461-472, ISSN 0012-1797
Publisher: American Diabetes Association
DOI: 10.2337/db17-0595

Lifestyle precision medicine: the next generation in type 2 diabetes prevention?

Author(s): Pascal M. Mutie, Giuseppe N. Giordano, Paul W. Franks
Published in: BMC Medicine, 15/1, 2017, ISSN 1741-7015
Publisher: BioMed Central
DOI: 10.1186/s12916-017-0938-x

Endoplasmic reticulum stress and eIF2α phosphorylation: The Achilles heel of pancreatic β cells

Author(s): Miriam Cnop, Sanna Toivonen, Mariana Igoillo-Esteve, Paraskevi Salpea
Published in: Molecular Metabolism, 6/9, 2017, Page(s) 1024-1039, ISSN 2212-8778
Publisher: Elsevier GmbH
DOI: 10.1016/j.molmet.2017.06.001

Prediction of Glucose Tolerance without an Oral Glucose Tolerance Test

Author(s): Rohit Babbar, Martin Heni, Andreas Peter, Martin Hrabě de Angelis, Hans-Ulrich Häring, Andreas Fritsche, Hubert Preissl, Bernhard Schölkopf, Róbert Wagner
Published in: Frontiers in Endocrinology, 9, 2018, ISSN 1664-2392
Publisher: Frontiers Media
DOI: 10.3389/fendo.2018.00082

Modeling human pancreatic beta cell dedifferentiation

Author(s): Marc Diedisheim, Masaya Oshima, Olivier Albagli, Charlotte Wennberg Huldt, Ingela Ahlstedt, Maryam Clausen, Suraj Menon, Alexander Aivazidis, Anne-Christine Andreasson, William G. Haynes, Piero Marchetti, Lorella Marselli, Mathieu Armanet, Fabrice Chimienti, Raphael Scharfmann
Published in: Molecular Metabolism, 10, 2018, Page(s) 74-86, ISSN 2212-8778
Publisher: Elsevier GmbH
DOI: 10.1016/j.molmet.2018.02.002

Novel subgroups of adult-onset diabetes and their association with outcomes: a data-driven cluster analysis of six variables

Author(s): Emma Ahlqvist, Petter Storm, Annemari Käräjämäki, Mats Martinell, Mozhgan Dorkhan, Annelie Carlsson, Petter Vikman, Rashmi B Prasad, Dina Mansour Aly, Peter Almgren, Ylva Wessman, Nael Shaat, Peter Spégel, Hindrik Mulder, Eero Lindholm, Olle Melander, Ola Hansson, Ulf Malmqvist, Åke Lernmark, Kaj Lahti, Tom Forsén, Tiinamaija Tuomi, Anders H Rosengren, Leif Groop
Published in: The Lancet Diabetes & Endocrinology, 6/5, 2018, Page(s) 361-369, ISSN 2213-8587
Publisher: Elsevier BV
DOI: 10.1016/s2213-8587(18)30051-2

Laser capture microdissection of human pancreatic islets reveals novel eQTLs associated with type 2 diabetes

Author(s): Amna Khamis, Mickaël Canouil, Afshan Siddiq, Hutokshi Crouch, Mario Falchi, Manon von Bulow, Florian Ehehalt, Lorella Marselli, Marius Distler, Daniela Richter, Jürgen Weitz, Krister Bokvist, Ioannis Xenarios, Bernard Thorens, Anke M. Schulte, Mark Ibberson, Amelie Bonnefond, Piero Marchetti, Michele Solimena, Philippe Froguel
Published in: Molecular Metabolism, 2019, ISSN 2212-8778
Publisher: Elsevier GmbH
DOI: 10.1016/j.molmet.2019.03.004

Pancreatic β-cell tRNA hypomethylation and fragmentation link TRMT10A deficiency with diabetes

Author(s): Cristina Cosentino, Sanna Toivonen, Esteban Diaz Villamil, Mohamed Atta, Jean-Luc Ravanat, Stéphane Demine, Andrea Alex Schiavo, Nathalie Pachera, Jean-Philippe Deglasse, Jean-Christophe Jonas, Diego Balboa, Timo Otonkoski, Ewan R Pearson, Piero Marchetti, Décio L Eizirik, Miriam Cnop, Mariana Igoillo-Esteve
Published in: Nucleic Acids Research, 46/19, 2018, Page(s) 10302-10318, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gky839

Local and regional control of calcium dynamics in the pancreatic islet

Author(s): Guy A. Rutter, David J. Hodson, Pauline Chabosseau, Elizabeth Haythorne, Timothy J. Pullen, Isabelle Leclerc
Published in: Diabetes, Obesity and Metabolism, 19, 2017, Page(s) 30-41, ISSN 1462-8902
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/dom.12990

The Expression of Aldolase B in Islets Is Negatively Associated With Insulin Secretion in Humans

Author(s): Felicia Gerst, Benjamin A Jaghutriz, Harald Staiger, Anke M Schulte, Estela Lorza-Gil, Gabriele Kaiser, Madhura Panse, Sieglinde Haug, Martin Heni, Monika Schütz, Mandy Stadion, Annette Schürmann, Flavia Marzetta, Mark Ibberson, Bence Sipos, Falko Fend, Thomas Fleming, Peter P Nawroth, Alfred Königsrainer, Silvio Nadalin, Silvia Wagner, Andreas Peter, Andreas Fritsche, Daniela Richter, Michele
Published in: The Journal of Clinical Endocrinology & Metabolism, 103/12, 2018, Page(s) 4373-4383, ISSN 0021-972X
Publisher: The Endocrine Society
DOI: 10.1210/jc.2018-00791

Decision models of prediabetes populations: A systematic review

Author(s): Jose Leal, Liam Mc Morrow, Waqar Khurshid, Eva Pagano, Talitha Feenstra
Published in: Diabetes, Obesity and Metabolism, 2019, ISSN 1462-8902
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/dom.13684

Inflammatory stress in islet β-cells: therapeutic implications for type 2 diabetes?

Author(s): Maria Lytrivi, Mariana Igoillo-Esteve, Miriam Cnop
Published in: Current Opinion in Pharmacology, 43, 2018, Page(s) 40-45, ISSN 1471-4892
Publisher: Elsevier BV
DOI: 10.1016/j.coph.2018.08.002

The tRNA epitranscriptome and diabetes: emergence of tRNA hypomodifications as a cause of pancreatic β-cell failure

Author(s): Cristina Cosentino, Miriam Cnop, Mariana Igoillo-Esteve
Published in: Endocrinology, 2019, ISSN 1945-7170
Publisher: Endocrine Society
DOI: 10.1210/en.2019-00098

ICA512 RESP18 homology domain is a protein condensing factor and insulin fibrillation inhibitor

Author(s): Pamela L. Toledo, Juha M. Torkko, Andreas Mueller, Carolin Wegbrod, Anke Sönmez, Michele Solimena, Mario R. Ermácora
Published in: Journal of Biological Chemistry, 2019, Page(s) 8564-8576, ISSN 0021-9258
Publisher: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/jbc.ra119.007607

NACHO: a Nanostring nCounter data QC package

Author(s): Mickaël Canouil, Gerard A Bouland, Amélie Bonnefond, Philippe Froguel, Leen ’t Hart, Roderick Slieker
Published in: Bioinformatics, 2019, ISSN 1367-4803
Publisher: Oxford University Press
DOI: 10.1093/bioinformatics/btz647

Leader β-cells coordinate Ca2+ dynamics across pancreatic islets in vivo

Author(s): Victoria Salem, Luis Delgadillo Silva, Kinga Suba, Eleni Georgiadou, S. Neda Mousavy Gharavy, Nadeem Akhtar, Aldara Martin-Alonso, David C. A. Gaboriau, Stephen M. Rothery, Theodoros Stylianides, Gaelle Carrat, Timothy J. Pullen, Sumeet Pal Singh, David J. Hodson, Isabelle Leclerc, A. M. James Shapiro, Piero Marchetti, Linford J. B. Briant, Walter Distaso, Nikolay Ninov, Guy A. Rutter
Published in: Nature Metabolism, 1/6, 2019, Page(s) 615-629, ISSN 2522-5812
Publisher: Nature Metabolism
DOI: 10.1038/s42255-019-0075-2

Klf6 protects β-cells against insulin resistance-induced dedifferentiation

Author(s): Christopher Dumayne, David Tarussio, Ana Rodriguez Sanchez-Archidona, Alexandre Picard, Davide Basco, Xavier Pascal Berney, Mark Ibberson, Bernard Thorens
Published in: Molecular Metabolism, 35, 2020, Page(s) 100958, ISSN 2212-8778
Publisher: Elsevier GmbH
DOI: 10.1016/j.molmet.2020.02.001

The supply chain of human pancreatic β cell lines

Author(s): Raphael Scharfmann, Willem Staels, Olivier Albagli
Published in: Journal of Clinical Investigation, 129/9, 2019, Page(s) 3511-3520, ISSN 0021-9738
Publisher: American Society for Clinical Investigation
DOI: 10.1172/jci129484

Synthesis and in vivo behaviour of an exendin-4-based MRI probe capable of β-cell-dependent contrast enhancement in the pancreas

Author(s): Thomas J. Clough, Nicoleta Baxan, Emma J. Coakley, Charlotte Rivas, Lan Zhao, Isabelle Leclerc, Aida Martinez-Sanchez, Guy A. Rutter, Nicholas J. Long
Published in: Dalton Transactions, 49/15, 2020, Page(s) 4732-4740, ISSN 1477-9226
Publisher: Royal Society of Chemistry
DOI: 10.1039/d0dt00332h

Stearoyl CoA desaturase is a gatekeeper that protects human beta cells against lipotoxicity and maintains their identity

Author(s): Masaya Oshima, Séverine Pechberty, Lara Bellini, Sven O. Göpel, Mélanie Campana, Claude Rouch, Julien Dairou, Cristina Cosentino, Federica Fantuzzi, Sanna Toivonen, Piero Marchetti, Christophe Magnan, Miriam Cnop, Hervé Le Stunff, Raphaël Scharfmann
Published in: Diabetologia, 63/2, 2020, Page(s) 395-409, ISSN 0012-186X
Publisher: Springer Verlag
DOI: 10.1007/s00125-019-05046-x

Fostering improved human islet research: a European perspective

Author(s): Piero Marchetti, Anke M. Schulte, Lorella Marselli, Eyke Schoniger, Marco Bugliani, Werner Kramer, Lut Overbergh, Susanne Ullrich, Anna L. Gloyn, Mark Ibberson, Guy Rutter, Philippe Froguel, Leif Groop, Mark I. McCarthy, Francesco Dotta, Raphael Scharfmann, Christophe Magnan, Decio L. Eizirik, Chantal Mathieu, Miriam Cnop, Bernard Thorens, Michele Solimena
Published in: Diabetologia, 62/8, 2019, Page(s) 1514-1516, ISSN 0012-186X
Publisher: Springer Verlag
DOI: 10.1007/s00125-019-4911-4

Use of preclinical models to identify markers of type 2 diabetes susceptibility and novel regulators of insulin secretion – A step towards precision medicine

Author(s): Bernard Thorens, Ana Rodriguez, Céline Cruciani-Guglielmacci, Leonore Wigger, Mark Ibberson, Christophe Magnan
Published in: Molecular Metabolism, 27, 2019, Page(s) S147-S154, ISSN 2212-8778
Publisher: Elsevier GmbH
DOI: 10.1016/j.molmet.2019.06.008

The Constitutive Lack of α7 Nicotinic Receptor Leads to Metabolic Disorders in Mouse

Author(s): Blandine Gausserès, Junjun Liu, Ewout Foppen, Cécile Tourrel-Cuzin, Ana Rodriguez Sanchez-Archidona, Etienne Delangre, Céline Cruciani-Guglielmacci, Stéphanie Pons, Uwe Maskos, Bernard Thorens, Christophe Magnan, Jamileh Movassat, Kamel Maouche
Published in: Biomolecules, 10/7, 2020, Page(s) 1057, ISSN 2218-273X
Publisher: MDPI
DOI: 10.3390/biom10071057

Paired box 6 programs essential exocytotic genes in the regulation of glucose-stimulated insulin secretion and glucose homeostasis

Author(s): So, WY; Liu, WN; Teo, AKK; Rutter, GA; Han, W
Published in: Science Translational Medicine, 2021, ISSN 1946-6234
Publisher: American Association for the Advancement of Science
DOI: 10.1126/scitranslmed.abb1038

The making of insulin in health and disease

Author(s): Vasiljević, Jovana; Torkko, Juha M.; Knoch, Klaus-Peter; Solimena, Michele
Published in: Diabetologia, 63, 2020, Page(s) 1981-1989, ISSN 0012-186X
Publisher: Springer Verlag
DOI: 10.1007/s00125-020-05192-7

Purification of pancreatic endocrine subsets reveals increased iron metabolism in beta cells

Author(s): C. Berthault, W. Staels, R. Scharfmann
Published in: Molecular Metabolism, 42, 2020, Page(s) 101060, ISSN 2212-8778
Publisher: Elsevier GmbH
DOI: 10.1016/j.molmet.2020.101060

Glucose treatment of human pancreatic β-cells enhances translation of mRNAs involved in energetics and insulin secretion

Author(s): Albatoul Zakaria, Claire Berthault, Bertrand Cosson, Vincent Jung, Ida Chiara Guerrera, Latif Rachdi, Raphael Scharfmann
Published in: Journal of Biological Chemistry, 297/1, 2021, Page(s) 100839, ISSN 0021-9258
Publisher: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1016/j.jbc.2021.100839

Metabolic and functional heterogeneity in pancreatic β cells

Author(s): Gabriela da Silva Xavier; Guy A. Rutter
Published in: Journal of Molecular Biology, 2, 2020, ISSN 0022-2836
Publisher: Academic Press
DOI: 10.1016/j.jmb.2019.08.005

Distinct Molecular Signatures of Clinical Clusters in People with Type 2 Diabetes: an IMIRHAPSODY Study

Author(s): Roderick C Slieker, Louise A Donnelly, Hugo Fitipaldi, Gerard A Bouland, Giuseppe N. Giordano, Mikael Åkerlund, Mathias J. Gerl, Emma Ahlqvist, Ashfaq Ali, Iulian Dragan, Petra Elders, Andreas Festa, Michael K. Hansen, Amber A van der Heijden, Dina Mansour Aly, Min Kim, Dmitry Kuznetsov, Florence Mehl, Christian Klose, Kai Simons, Imre Pavo, Timothy J. Pullen, Tommi Suvitaival, Asger Wretlind, Pe
Published in: Diabetes, 2021, Page(s) db201281, ISSN 0012-1797
Publisher: American Diabetes Association
DOI: 10.2337/db20-1281

Control by Ca2+ of mitochondrial structure and function in pancreatic β-cells

Author(s): Eleni Georgiadou, Guy A. Rutter
Published in: Cell Calcium, 91, 2020, Page(s) 102282, ISSN 0143-4160
Publisher: Churchill Livingstone
DOI: 10.1016/j.ceca.2020.102282

Replication and cross-validation of type 2 diabetes subtypes based on clinical variables: an IMI-RHAPSODY study

Author(s): Slieker, Roderick C.; Donnelly, Louise A.; Fitipaldi, Hugo; Bouland, Gerard A.; Giordano, Giuseppe N.; Åkerlund, Mikael; Gerl, Mathias J.; Ahlqvist, Emma; Ali, Ashfaq; Dragan, Iulian; Festa, Andreas; Hansen, Michael K.; Mansour Aly, Dina; Kim, Min; Kuznetsov, Dmitry; Mehl, Florence; Klose, Christian; Simons, Kai; Pavo, Imre; Pullen, Timothy J.; Suvitaival, Tommi; Wretlind, Asger; Rossing, Peter;
Published in: Diabetologia, 64, 2021, Page(s) 1982–1989, ISSN 0012-186X
Publisher: Springer Verlag
DOI: 10.1007/s00125-021-05490-8

Adipocyte-specific deletion of Tcf7l2 induces dysregulated lipid metabolism and impairs glucose tolerance in mice

Author(s): Marie-Sophie Nguyen-Tu, Aida Martinez-Sanchez, Isabelle Leclerc, Guy A. Rutter, Gabriela da Silva Xavier
Published in: Diabetologia, 64/1, 2021, Page(s) 129-141, ISSN 0012-186X
Publisher: Springer Verlag
DOI: 10.1007/s00125-020-05292-4

Functional Genomics in Pancreatic β Cells: Recent Advances in Gene Deletion and Genome Editing Technologies for Diabetes Research

Author(s): Ming Hu, Ines Cherkaoui, Shivani Misra, Guy A. Rutter
Published in: Frontiers in Endocrinology, 11, 2020, Page(s) 576-632, ISSN 1664-2392
Publisher: Frontiers in Endocrinology
DOI: 10.3389/fendo.2020.576632

Deciphering the Link Between Hyperhomocysteinemia and Ceramide Metabolism in Alzheimer-Type Neurodegeneration

Author(s): Hervé Le Stunff, Julien Véret, Nadim Kassis, Jessica Denom, Kelly Meneyrol, Jean-Louis Paul, Céline Cruciani-Guglielmacci, Christophe Magnan, Nathalie Janel
Published in: Frontiers in Neurology, 10, 2019, ISSN 1664-2295
Publisher: Frontiers Research Foundation
DOI: 10.3389/fneur.2019.00807

Dysfunction of Persisting β Cells Is a Key Feature of Early Type 2 Diabetes Pathogenesis

Author(s): Cohrs, Christian M.; Panzer, Julia K.; Drotar, Denise M.; Enos, Stephen J.; Kipke, Nicole; Chen, Chunguang; Bozsak, Robert; Schöniger, Eyke; Ehehalt, Florian; Distler, Marius; Brennand, Ana; Bornstein, Stefan R.; Weitz, Jürgen; Solimena, Michele; Speier, Stephan
Published in: Cell Reports, 31, 2020, Page(s) 107469, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2020.03.033

Consequences for Pancreatic β-Cell Identity and Function of Unregulated Transcript Processing

Author(s): Seyed M. Ghiasi, Guy A. Rutter
Published in: Frontiers in Endocrinology, 12, 2021, ISSN 1664-2392
Publisher: Frontiers
DOI: 10.3389/fendo.2021.625235

CONQUER: an interactive toolbox to understand functional consequences of GWAS hits

Author(s): Bouland, Gerard A; Beulens, Joline WJ; Nap, Joey; van der Slik, Arno R; Zaldumbide, Arnaud; Hart, Leen M’t; Slieker, Roderick C
Published in: NAR Genomics and Bioinformatics, 2, 2020, ISSN 2631-9268
Publisher: Oxford University Press
DOI: 10.1093/nargab/lqaa085

Sexually dimorphic roles for the type 2 diabetes-associated C2cd4b gene in murine glucose homeostasis

Author(s): S. Neda Mousavy Gharavy, Bryn M. Owen, Steven J. Millership, Pauline Chabosseau, Grazia Pizza, Aida Martinez-Sanchez, Emirhan Tasoez, Eleni Georgiadou, Ming Hu, Nicholas H. F. Fine, David A. Jacobson, Matthew T. Dickerson, Olof Idevall-Hagren, Alex Montoya, Holger Kramer, Zenobia Mehta, Dominic J. Withers, Nikolay Ninov, Paul J. Gadue, Fabian L. Cardenas-Diaz, Céline Cruciani-Guglielmacci, Christ
Published in: Diabetologia, 64/4, 2021, Page(s) 850-864, ISSN 0012-186X
Publisher: Springer Verlag
DOI: 10.1007/s00125-020-05350-x

Manipulation and Measurement of AMPK activity in pancreatic islets

Author(s): Aida Martinez-Sanchez, Marie-Sophie Nguyen-Tu, Isabelle Leclerc, Guy A. Rutter
Published in: 2017, Page(s) 413-431
Publisher: Springer New York
DOI: 10.1007/978-1-4939-7598-3_26

The type 2 diabetes gene product STARD10 is a phosphoinositide binding protein that controls insulin secretory granule biogenesis

Author(s): Gaelle R. Carrat, Elizabeth Haythorne, Alejandra Tomas, Leena Haataja, Andreas Müller, Peter Arvan, Alexandra Piunti, Kaiying Cheng, Mutian Huang, Timothy J. Pullen, Eleni Georgiadou, Theodoros Stylianides, Nur Shabrina Amirruddin, Victoria Salem, Walter Distaso, Andrew Cakebread, Kate J.Heesom, Philip A. Lewis, David J. Hodson, Linford J. Briant, Annie C.H. Fung, Richard B. Sessions, Fabien
Published in: Molecular Metabolism, 40, 2020, Page(s) 101015, ISSN 2212-8778
Publisher: Elsevier GmbH
DOI: 10.1016/j.molmet.2020.101015

Covid-19 and Diabetes: A Complex Bidirectional Relationship

Author(s): Muniangi-Muhitu, Hermine; Akalestou, Elina; Salem, Victoria; Misra, Shivani; Oliver, Nicholas S.; Rutter, Guy A.
Published in: Frontiers in Endocrinology, 11, 2020, Page(s) 582936, ISSN 1664-2392
Publisher: Frontiers Media SA
DOI: 10.3389/fendo.2020.582936