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IN-Silico trials for treatment of acute Ischemic STroke

Deliverables

Implementation of full 3D characterized models

Implementation of full 3D characterized models

Initial integration of all models

Initial integration of all models

Finite element meshes of patient specific clot and vessel geometries

Finite element meshes of patient specific clot and vessel geometries

Second report on models for advanced versions thrombosis and thrombolysis and combined model including validation and the formal VVUQ and reports on the experiments carried out during the second 18 months of the project

Second report on models for advanced versions thrombosis and thrombolysis and combined model including validation and the formal VVUQ and reports on the experiments carried out during the second 18 months of the project. This deliverables is not just a report, but will also deliver the associated models as simulation software (e.g. to WP6).

Implementation of individual models of interaction

Implementation of individual models of interaction

Quality Assurance Plan

Quality Assurance Plan to manage the quality control including a detailed risk analysis and contingency planning

In silico model for mechanical performance of thrombectomy devices

In silico model for mechanical performance of thrombectomy devices

Project Handbook

Project Handbook to ensure consistent implementation of the management

Implementation of model of microvascular damage

Implementation of model of microvascular damage

Data Management Plan template

Data Management Plan template

Data base of composition-specific clot mechanical properties and a new constitutive law for clots

Data base of composition-specific clot mechanical properties and a new constitutive law for clots

First public version of a population model to generate virtual populations

First public version of a population model to generate virtual populations

Initial report on dissemination, exploitation and sustainability plan

Initial report on dissemination, exploitation and sustainability plan with a detailed plan and schedule for all dissemination, communication, and exploitation activities. The plan will be delivered in M3, and updated to coincide with reporting period Note: All the tasks and deliverables depicted in this WP will be implemented taking into account the best practices in Data Management (WP1) and the template for Data Management Plan (D1.6)

Periodic reporting

Periodic technical reports and periodic financial and ethical reports for the EC. Report is due month 20

Implementation of VVUQ procedures and initial validation exercises on integrated models

Implementation of VVUQ procedures and initial validation exercises on integrated models

An in silico clinical stroke trial computing environment

An in silico clinical stroke trial computing environment

First report on models for thrombosis and thrombolysis and combined model describing the models and performed experiments

First report on models for thrombosis and thrombolysis and combined model describing the models and performed experiments. This deliverables is not just a report, but will also deliver the associated models as simulation software (e.g. to WP6).

Consortium Agreement

Consortium Agreement

Second report on dissemination, communication and sustainability

Second dissemination, communication and sustainability report. Note: All the tasks and deliverables depicted in this WP will be implemented taking into account the best practices in Data Management (WP1) and the template for Data Management Plan (D1.6)

First report on dissemination, communication and sustainability

First dissemination, communication and sustainability report, with a review of events dissemination, communication, and exploitation results including an update of dissemination, communication, and exploitation action plan Note: All the tasks and deliverables depicted in this WP will be implemented taking into account the best practices in Data Management (WP1) and the template for Data Management Plan (D1.6)

First version of a virtual population of stroke patients (Module I)

First version of a virtual population of stroke patients (Module I)

Final Statistical model that relates images features of clot to clot characteristics

Final statistical model that relates images features of clot to clot characteristics

Publications

Early recanalization in large-vessel occlusion stroke patients transferred for endovascular treatment

Author(s): Nerea Arrarte Terreros, Agnetha A E Bruggeman, Isabella S J Swijnenburg, Laura C C van Meenen, Adrien E Groot, Jonathan M Coutinho, Yvo B W E M Roos, Bart J Emmer, Ludo F M Beenen, Ed van Bavel, Henk A Marquering, Charles B L M Majoie
Published in: Journal of NeuroInterventional Surgery, 2021, Page(s) neurintsurg-2021-017441, ISSN 1759-8478
DOI: 10.1136/neurintsurg-2021-017441

A porous circulation model of the human brain for in silico clinical trials in ischaemic stroke

Author(s): T. I. Józsa, R. M. Padmos, N. Samuels, W. K. El-Bouri, A. G. Hoekstra, S. J. Payne
Published in: Interface Focus, Issue 11/1, 2021, Page(s) 20190127, ISSN 2042-8898
DOI: 10.1098/rsfs.2019.0127

Impact of the Internal Carotid Artery Morphology on in silico Stent-Retriever Thrombectomy Outcome

Author(s): Sara Bridio, Giulia Luraghi, Jose F. Rodriguez Matas, Gabriele Dubini, Giorgia G. Giassi, Greta Maggio, Julia N. Kawamoto, Kevin M. Moerman, Patrick McGarry, Praneeta R. Konduri, Nerea Arrarte Terreros, Henk A. Marquering, Ed van Bavel, Charles B. L. M. Majoie, Francesco Migliavacca
Published in: Frontiers in Medical Technology, Issue 3, 2021, ISSN 2673-3129
DOI: 10.3389/fmedt.2021.719909

Blood clot fracture properties are dependent on red blood cell and fibrin content

Author(s): B. Fereidoonnezhad; Anushree Dwivedi; Sarah E. Johnson; Ray McCarthy; Patrick McGarry
Published in: Acta Biomaterialia, Issue 7, 2021, Page(s) 213-228, ISSN 1742-7061
DOI: 10.1101/2020.10.05.326165

Mechanical Characterization of Thrombi Retrieved With Endovascular Thrombectomy in Patients With Acute Ischemic Stroke

Author(s): Nikki Boodt, Philip R.W. Snouckaert van Schauburg, Hajo M. Hund, Behrooz Fereidoonnezhad, J. Patrick McGarry, Ali C. Akyildiz, Adriaan C.G.M. van Es, Simon F. De Meyer, Diederik W.J. Dippel, Hester F. Lingsma, Heleen M.M. van Beusekom, Aad van der Lugt, Frank J.H. Gijsen
Published in: Stroke, Issue 52/8, 2021, Page(s) 2510-2517, ISSN 0039-2499
DOI: 10.1161/strokeaha.120.033527

Red blood cell and platelet diffusivity and margination in the presence of cross-stream gradients in blood flows

Author(s): Gábor Závodszky, Britt van Rooij, Ben Czaja, Victor Azizi, David de Kanter, Alfons G. Hoekstra
Published in: Physics of Fluids, Issue 31/3, 2019, Page(s) 031903, ISSN 1070-6631
DOI: 10.1063/1.5085881

Investigating the Mechanical Behavior of Clot Analogues Through Experimental and Computational Analysis

Author(s): Sarah Johnson, Ray McCarthy, Michael Gilvarry, Peter E. McHugh, J. Patrick McGarry
Published in: Annals of Biomedical Engineering, Issue 49/1, 2021, Page(s) 420-431, ISSN 0090-6964
DOI: 10.1007/s10439-020-02570-5

Structural analysis of ischemic stroke thrombi: histological indications for therapy resistance

Author(s): Senna Staessens, Frederik Denorme, Olivier Francois, Linda Desender, Tom Dewaele, Peter Vanacker, Hans Deckmyn, Karen Vanhoorelbeke, Tommy Andersson, Simon F. De Meyer
Published in: Haematologica, Issue 105/2, 2020, Page(s) 498-507, ISSN 0390-6078
DOI: 10.3324/haematol.2019.219881

Applicability analysis to evaluate credibility of an in silico thrombectomy procedure

Author(s): Giulia Luraghi, Sara Bridio, Claire Miller, Alfons Hoekstra, Jose Felix Rodriguez Matas, Francesco Migliavacca
Published in: Journal of Biomechanics, Issue 126, 2021, Page(s) 110631, ISSN 0021-9290
DOI: 10.1016/j.jbiomech.2021.110631

Modelling the leptomeningeal collateral circulation during acute ischaemic stroke

Author(s): Raymond M. Padmos, Nerea Arrarte Terreros, Tamás I. Józsa, Gábor Závodszky, Henk A. Marquering, Charles B.L.M. Majoie, Alfons G. Hoekstra
Published in: Medical Engineering & Physics, Issue 91, 2021, Page(s) 1-11, ISSN 1350-4533
DOI: 10.1016/j.medengphy.2021.03.003

The first virtual patient-specific thrombectomy procedure

Author(s): Giulia Luraghi, Sara Bridio, Jose Felix Rodriguez Matas, Gabriele Dubini, Nikki Boodt, Frank J.H. Gijsen, Aad van der Lugt, Behrooz Fereidoonnezhad, Kevin M. Moerman, Patrick McGarry, Praneeta R. Konduri, Nerea Arrarte Terreros, Henk A. Marquering, Charles B.L.M. Majoie, Francesco Migliavacca
Published in: Journal of Biomechanics, Issue 126, 2021, Page(s) 110622, ISSN 0021-9290
DOI: 10.1016/j.jbiomech.2021.110622

In vitro and in silico modeling of endovascular stroke treatments for acute ischemic stroke

Author(s): Giulia Luraghi, Rachel M.E. Cahalane, Emma van de Ven, Serena C.M. Overschie, Frank J.H. Gijsen, Ali C. Akyildiz
Published in: Journal of Biomechanics, Issue 127, 2021, Page(s) 110693, ISSN 0021-9290
DOI: 10.1016/j.jbiomech.2021.110693

Is modeling stents still an important issue?

Author(s): Francesco Migliavacca
Published in: Procedia Structural Integrity, Issue 15, 2019, Page(s) 46-50, ISSN 2452-3216
DOI: 10.1016/j.prostr.2019.07.009

A new anisotropic soft tissue model for elimination of unphysical auxetic behaviour

Author(s): B. Fereidoonnezhad, C. O’Connor, J.P. McGarry
Published in: Journal of Biomechanics, Issue 111, 2020, Page(s) 110006, ISSN 0021-9290
DOI: 10.1016/j.jbiomech.2020.110006

Recovery of Hypoxic Regions in a Rat Model of Microembolism

Author(s): Theodosia Georgakopoulou, Anne-Eva van der Wijk, Erik N.T.P. Bakker, Ed vanBavel
Published in: Journal of Stroke and Cerebrovascular Diseases, Issue 30/6, 2021, Page(s) 105739, ISSN 1052-3057
DOI: 10.1016/j.jstrokecerebrovasdis.2021.105739

Stroke Etiology and Thrombus Computed Tomography Characteristics in Patients With Acute Ischemic Stroke

Author(s): Nikki Boodt, Kars C.J. Compagne, Bruna G. Dutra, Noor Samuels, Manon L. Tolhuisen, Heitor C.B.R. Alves, Manon Kappelhof, Geert J. Lycklama à Nijeholt, Henk. A. Marquering, Charles B.L.M. Majoie, Hester F. Lingsma, Diederik W.J. Dippel, Aad van der Lugt, Yvo Roos, Robert van Oostenbrugge, Wim van Zwam, Jelis Boiten, Jan Albert Vos, Ivo Jansen, Maxim Mulder, Robert-Jan Goldhoorn, Wouter Schonewille
Published in: Stroke, Issue 51/6, 2020, Page(s) 1727-1735, ISSN 0039-2499
DOI: 10.1161/strokeaha.119.027749

From perviousness to permeability, modelling and measuring intra-thrombus flow in acute ischemic stroke

Author(s): Nerea Arrarte Terreros, Manon L. Tolhuisen, Edwin Bennink, Hugo W.A.M. de Jong, Ludo F.M. Beenen, Charles B.L.M. Majoie, Ed van Bavel, Henk A. Marquering
Published in: Journal of Biomechanics, Issue 111, 2020, Page(s) 110001, ISSN 0021-9290
DOI: 10.1016/j.jbiomech.2020.110001

A new compressible hyperelastic model for the multi-axial deformation of blood clot occlusions in vessels

Author(s): Behrooz Fereidoonnezhad, Kevin M. Moerman, Sarah Johnson, Ray McCarthy, Patrick J. McGarry
Published in: Biomechanics and Modeling in Mechanobiology, 2021, ISSN 1617-7959
DOI: 10.1007/s10237-021-01446-4

Extravasation of Microspheres in a Rat Model of Silent Brain Infarcts

Author(s): Anne-Eva van der Wijk, Nadia Lachkar, Judith de Vos, Anita E. Grootemaat, Nicole N. van der Wel, Peter L. Hordijk, Erik N.T.P. Bakker, Ed vanBavel
Published in: Stroke, Issue 50/6, 2019, Page(s) 1590-1594, ISSN 0039-2499
DOI: 10.1161/strokeaha.119.024975

On the Sensitivity Analysis of Porous Finite Element Models for Cerebral Perfusion Estimation

Author(s): T. I. Józsa, R. M. Padmos, W. K. El-Bouri, A. G. Hoekstra, S. J. Payne
Published in: Annals of Biomedical Engineering, 2021, ISSN 0090-6964
DOI: 10.1007/s10439-021-02808-w

In-Silico Trials for Treatment of Acute Ischemic Stroke

Author(s): Praneeta R. Konduri, Henk A. Marquering, Ed E. van Bavel, Alfons Hoekstra, Charles B. L. M. Majoie
Published in: Frontiers in Neurology, Issue 11, 2020, ISSN 1664-2295
DOI: 10.3389/fneur.2020.558125

Novel hyperelastic models for large volumetric deformations

Author(s): Kevin M. Moerman, Behrooz Fereidoonnezhad, J. Patrick McGarry
Published in: International Journal of Solids and Structures, Issue 193-194, 2020, Page(s) 474-491, ISSN 0020-7683
DOI: 10.1016/j.ijsolstr.2020.01.019

Structural analysis of ischemic stroke thrombi: histological indications for therapy resistance

Author(s): Senna Staessens, Frederik Denorme, Olivier François, Linda Desender, Tom Dewaele, Peter Vanacker, Hans Deckmyn, Karen Vanhoorelbeke, Tommy Andersson, Simon F De Meyer
Published in: Haematologica, Issue May 2019;104, 2019, ISSN 0390-6078

Histological stroke clot analysis after thrombectomy: Technical aspects and recommendations

Author(s): S Staessens, S Fitzgerald, T Andersson, F Clarençon, F Denorme, MJ Gounis, W Hacke, DS Liebeskind, I Szikora, ACGM van Es, W Brinjikji, KM Doyle, SF De Meyer
Published in: International Journal of Stroke, Issue 15/5, 2020, Page(s) 467-476, ISSN 1747-4930
DOI: 10.1177/1747493019884527

Detailed histological analysis of a thrombectomy-resistant ischemic stroke thrombus: a case report

Author(s): Senna Staessens, Olivier François, Linda Desender, Peter Vanacker, Tom Dewaele, Raf Sciot, Karen Vanhoorelbeke, Tommy Andersson, Simon F. De Meyer
Published in: Thrombosis Journal, Issue 19/1, 2021, ISSN 1477-9560
DOI: 10.1186/s12959-021-00262-1

Thrombus heterogeneity in ischemic stroke

Author(s): Senna Staessens, Simon F. De Meyer
Published in: Platelets, 2020, Page(s) 1-9, ISSN 0953-7104
DOI: 10.1080/09537104.2020.1748586

Investigating the two regimes of fibrin clot lysis: an experimental and computational approach

Author(s): Franck Raynaud, Alexandre Rousseau, Daniel Monteyne, David Perez-Morga, Karim Zouaoui Boudjeltia, Bastien Chopard
Published in: Biophysical Journal, Issue 120/18, 2021, Page(s) 4091-4106, ISSN 0006-3495
DOI: 10.1016/j.bpj.2021.08.005

Blood pressure during endovascular treatment under conscious sedation or local anesthesia

Author(s): Noor Samuels, Rob A. van de Graaf, Carlijn A.L. van den Berg, Daan Nieboer, Ismail Eralp, Kilian M. Treurniet, Bart J. Emmer, Rogier V. Immink, Charles B.L.M. Majoie, Wim H. van Zwam, Reinoud P.H. Bokkers, Maarten Uyttenboogaart, Boudewijn A.A.M. van Hasselt, Jörg Mühling, James F. Burke, Bob Roozenbeek, Aad van der Lugt, Diederik W.J. Dippel, Hester F. Lingsma, Adriaan C.G.M. van Es
Published in: Neurology, 2020, Page(s) 10.1212/WNL.0000000000011006, ISSN 0028-3878
DOI: 10.1212/wnl.0000000000011006

Coupling one-dimensional arterial blood flow to three-dimensional tissue perfusion models for in silico trials of acute ischaemic stroke

Author(s): Raymond M. Padmos, Tamás I. Józsa, Wahbi K. El-Bouri, Praneeta R. Konduri, Stephen J. Payne, Alfons G. Hoekstra
Published in: Interface Focus, Issue 11/1, 2021, Page(s) 20190125, ISSN 2042-8898
DOI: 10.1098/rsfs.2019.0125

In silico trials for treatment of acute ischemic stroke: Design and implementation

Author(s): Claire Miller, Raymond M. Padmos, Max van der Kolk, Tamás I. Józsa, Noor Samuels, Yidan Xue, Stephen J. Payne, Alfons G. Hoekstra
Published in: Computers in Biology and Medicine, Issue 137, 2021, Page(s) 104802, ISSN 0010-4825
DOI: 10.1016/j.compbiomed.2021.104802

Applicability assessment of a stent-retriever thrombectomy finite-element model

Author(s): Giulia Luraghi, Jose Felix Rodriguez Matas, Gabriele Dubini, Francesca Berti, Sara Bridio, Sharon Duffy, Anushree Dwivedi, Ray McCarthy, Behrooz Fereidoonnezhad, Patrick McGarry, Charles B. L. M. Majoie, Francesco Migliavacca
Published in: Interface Focus, Issue 11/1, 2021, Page(s) 20190123, ISSN 2042-8898
DOI: 10.1098/rsfs.2019.0123

Microembolus clearance through angiophagy is an auxiliary mechanism preserving tissue perfusion in the rat brain

Author(s): Anne-Eva van der Wijk, Theodosia Georgakopoulou, Jisca Majolée, Jan S. M. van Bezu, Miesje M. van der Stoel, Bert J. van het Hof, Helga E. de Vries, Stephan Huveneers, Peter L. Hordijk, Erik N. T. P. Bakker, Ed van Bavel
Published in: Acta Neuropathologica Communications, Issue 8/1, 2020, ISSN 2051-5960
DOI: 10.1186/s40478-020-01071-9

Uncertainty Quantification of Coupled 1D Arterial Blood Flow and 3D Tissue Perfusion Models Using the INSIST Framework

Author(s): Claire Miller, Max van der Kolk, Raymond Padmos, Tamás Józsa, Alfons Hoekstra
Published in: Computational Science – ICCS 2021 - 21st International Conference, Krakow, Poland, June 16–18, 2021, Proceedings, Part VI, Issue 12747, 2021, Page(s) 691-697
DOI: 10.1007/978-3-030-77980-1_52

Two-Way Coupling Between 1D Blood Flow and 3D Tissue Perfusion Models

Author(s): Raymond M. Padmos, Tamás I. Józsa, Wahbi K. El-Bouri, Gábor Závodszky, Stephen J. Payne, Alfons G. Hoekstra
Published in: Computational Science – ICCS 2021 - 21st International Conference, Krakow, Poland, June 16–18, 2021, Proceedings, Part III, Issue 12744, 2021, Page(s) 670-683
DOI: 10.1007/978-3-030-77967-2_56

des-ist: A Simulation Framework to Streamline Event-Based In Silico Trials

Author(s): Max van der Kolk, Claire Miller, Raymond Padmos, Victor Azizi, Alfons Hoekstra
Published in: Computational Science – ICCS 2021 - 21st International Conference, Krakow, Poland, June 16–18, 2021, Proceedings, Part III, Issue 12744, 2021, Page(s) 648-654
DOI: 10.1007/978-3-030-77967-2_53

Novel hyperelastic models for large volumetric deformations

Author(s): Kevin M. Moerman; Behrooz Fereidoonnezhad; J. Patrick McGarry
Published in: Issue 1, 2019
DOI: 10.31224/OSF.IO/CFXDR

INSIST - IN SILICO TRIALS FOR TREATMENT OF ACUTE ISCHEMIC STROKE

Author(s): Konduri, Praneeta
Published in: Issue 3, 2018
DOI: 10.26226/morressier.5aeac941521e300021137ff8

Datasets

Investigating the two regimes of fibrin clot lysis: an experimental and computational approach

Author(s): Raynaud, Franck; Rousseau, Alexandre; Monteyne, Daniel; Perez-Morga, David; Zouaoui Boudjeltia, Karim; Chopard, Bastien
Published in: Zenodo

Investigating the two regimes of fibrin clot lysis: an experimental and computational approach

Author(s): Raynaud, Franck; Rousseau, Alexandre; Monteyne, Daniel; Perez-Morga, David; Zouaoui Boudjeltia, Karim; Chopard, Bastien
Published in: Zenodo