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IN-Silico trials for treatment of acute Ischemic STroke

Deliverables

Implementation of full 3D characterized models

Implementation of full 3D characterized models

Initial integration of all models

Initial integration of all models

Finite element meshes of patient specific clot and vessel geometries

Finite element meshes of patient specific clot and vessel geometries

Second report on models for advanced versions thrombosis and thrombolysis and combined model including validation and the formal VVUQ and reports on the experiments carried out during the second 18 months of the project

Second report on models for advanced versions thrombosis and thrombolysis and combined model including validation and the formal VVUQ and reports on the experiments carried out during the second 18 months of the project. This deliverables is not just a report, but will also deliver the associated models as simulation software (e.g. to WP6).

Implementation of individual models of interaction

Implementation of individual models of interaction

Quality Assurance Plan

Quality Assurance Plan to manage the quality control including a detailed risk analysis and contingency planning

In silico model for mechanical performance of thrombectomy devices

In silico model for mechanical performance of thrombectomy devices

Project Handbook

Project Handbook to ensure consistent implementation of the management

Implementation of model of microvascular damage

Implementation of model of microvascular damage

Data Management Plan template

Data Management Plan template

Data base of composition-specific clot mechanical properties and a new constitutive law for clots

Data base of composition-specific clot mechanical properties and a new constitutive law for clots

First public version of a population model to generate virtual populations

First public version of a population model to generate virtual populations

Initial report on dissemination, exploitation and sustainability plan

Initial report on dissemination, exploitation and sustainability plan with a detailed plan and schedule for all dissemination, communication, and exploitation activities. The plan will be delivered in M3, and updated to coincide with reporting period Note: All the tasks and deliverables depicted in this WP will be implemented taking into account the best practices in Data Management (WP1) and the template for Data Management Plan (D1.6)

Periodic reporting

Periodic technical reports and periodic financial and ethical reports for the EC. Report is due month 20

Implementation of VVUQ procedures and initial validation exercises on integrated models

Implementation of VVUQ procedures and initial validation exercises on integrated models

An in silico clinical stroke trial computing environment

An in silico clinical stroke trial computing environment

First report on models for thrombosis and thrombolysis and combined model describing the models and performed experiments

First report on models for thrombosis and thrombolysis and combined model describing the models and performed experiments. This deliverables is not just a report, but will also deliver the associated models as simulation software (e.g. to WP6).

Consortium Agreement

Consortium Agreement

Second report on dissemination, communication and sustainability

Second dissemination, communication and sustainability report. Note: All the tasks and deliverables depicted in this WP will be implemented taking into account the best practices in Data Management (WP1) and the template for Data Management Plan (D1.6)

First report on dissemination, communication and sustainability

First dissemination, communication and sustainability report, with a review of events dissemination, communication, and exploitation results including an update of dissemination, communication, and exploitation action plan Note: All the tasks and deliverables depicted in this WP will be implemented taking into account the best practices in Data Management (WP1) and the template for Data Management Plan (D1.6)

First version of a virtual population of stroke patients (Module I)

First version of a virtual population of stroke patients (Module I)

Final Statistical model that relates images features of clot to clot characteristics

Final statistical model that relates images features of clot to clot characteristics

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Publications

Structural analysis of ischemic stroke thrombi: histological indications for therapy resistance

Author(s): Senna Staessens, Frederik Denorme, Olivier François, Linda Desender, Tom Dewaele, Peter Vanacker, Hans Deckmyn, Karen Vanhoorelbeke, Tommy Andersson, Simon F De Meyer
Published in: Haematologica, Issue May 2019;104, 2019, ISSN 0390-6078