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IMaging-based CUSTOMised EYE diagnostics

Deliverables

Report of viscoelastic parameters in first sets of eyes

Report of viscoelastic parameters in first sets of eyes, including enucleated eyes, normal eyes in vivo and 2D keratoconus and CXL eyes

Internet outreach and social media

The domain http://www.imcustomeye.eu has been acquired for the IMCUSTOMEYE project, and will be updated by the coordinating team with public information from research reports and activities related with the project. Announcements will be distributed through a linked blog and a dedicated twitter account. Flyers presenting research to the public will be printed and distributed; information for the clinician and patient will be generated and disseminated through the web and social media.

Report demonstrating the technique on enucleated eyes

Corneal deformation imaging in porcine corneas ex vivo (normal, after IOP-reducing drops and cross-linking) and human donor eyes ex vivo.

Report demonstrating the techniques in human eyes in vivo

Corneal deformation imaging in normal eyes in vivo

Dissemination Plan

A Dissemination Plan will be prepared during the first 4 months of the project, identifying the most appropriate communication channels and tools for dissemination of key research findings related to all work-packages to a wide range of audiences.

Innovation management report

Innovation management report. This activity will be in coordination with WP8

Video clips

Short (<2 min) video clips will be made showcasing the results for the research and clinical work packages, after IP protection has been secured. The videos will be aimed at the general public, and will serve as explanatory material to potential investors in a commercialisation phase. *Months 12, 24 and 36

Press releases and media coverage

Publications in high impact journals and relevant achievements will be presented in press releases (both institutional and newsletters from academic and professional societies where project members have influence). Media coverage (television, radio, press, podcasts) is expected following press releases. Special attention will be made to seek broadcasting by European media, such as Euronews. *Months 18, 30 and 42

Project intranet in operation

The established SharePoint site will be launched, with areas for each work package, internal management, document tracking and internal communication.

Functional acoustic stimulation vibrational ps-nsOCT

Acoustic stimulation module, adapted OCT platforms

OCT platform for integration into miniaturised device and testing

OCT platform for integration into miniaturised device and testing

Functional 3D air-puff OCT imaging experimental systems

Integrated hardware and software control in OCT for acquisition of 3D corneal deformation images synchronised to air-puff.

Publications

Customised optical coherence tomography system for corneal deformation imaging on multiple meridians

Author(s): A. Curatolo, J. Birkenfeld, J. A. Germann, A. de Castro, G. Muralidharan, M. Velasco, E. Martínez, and S. Marcos
Published in: 2018

Assessment of ocular mechanical resonances using phase-sensitive OCT and frequency-domain air puff stimulation

Author(s): J. Birkenfeld, A. Ramier, B. Tavakol, S. Marcos and S. Yun
Published in: 2018

Obtaining biomechanical properties of corneal tissue in-vivo using a non-contact method

Author(s): Elsheikh, A., Eliasy, A., Chen, K. J., & Vinciguerra, R.
Published in: 2018

Fluid Structure Interaction (FSI) Simulation Of the human eye under the air puff tonometry using Computational Fluid Dynamics (CFD)

Author(s): Maklad, O., Theofilis, V., & Elsheikh, A.
Published in: 2018

Intraocular Pressure Measurement Pre- and Post Refractive Surgery Using GAT and CorVis ST bIOP Algorithm

Author(s): Eliasy, A., Elsheikh, A., & Chen, K. -J.
Published in: 2018

Novel Intraocular Pressure Measurement Algorithm for Patients with Keratoconus

Author(s): Eliasy, A., Chen, K. J., Vinciguerra, R., & Elsheikh, A.
Published in: 2018

Assessment of the influence of viscoelasticity of cornea in animal ex vivo model using air-puff optical coherence tomography and corneal hysteresis

Author(s): Ewa Maczynska, Karol Karnowski, Krzysztof Szulzycki, Monika Malinowska, Hubert Dolezyczek, Artur Cichanski, Maciej Wojtkowski, Bartlomiej Kaluzny, Ireneusz Grulkowski
Published in: Journal of Biophotonics, Issue 12/2, 2019, Page(s) e201800154, ISSN 1864-063X
DOI: 10.1002/jbio.201800154

Background Subtraction Vs Highpass filtering in phase sensitive Optica Coherence Tomography

Author(s): Ryan McAuley, A. Nolan, K. Larin, M. Singh, S. Alexandrov, Martin Leahy
Published in: Bi-annual Biophotonics and Imaging Summer School (BIGSS'18), 2018

Biomechanics of the Eye _ Chapter 6. Material properties of the human cornea: anisotropy

Author(s): Eliasy, A., Zhou, D., Studer, H., Boote, C., & Elsheikh, A.
Published in: Material properties of the human cornea: anisotropy, 2018