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IMaging-based CUSTOMised EYE diagnostics


Report of viscoelastic parameters in first sets of eyes

Report of viscoelastic parameters in first sets of eyes, including enucleated eyes, normal eyes in vivo and 2D keratoconus and CXL eyes

Internet outreach and social media

The domain has been acquired for the IMCUSTOMEYE project, and will be updated by the coordinating team with public information from research reports and activities related with the project. Announcements will be distributed through a linked blog and a dedicated twitter account. Flyers presenting research to the public will be printed and distributed; information for the clinician and patient will be generated and disseminated through the web and social media.

Report demonstrating the technique on enucleated eyes

Corneal deformation imaging in porcine corneas ex vivo (normal, after IOP-reducing drops and cross-linking) and human donor eyes ex vivo.

Report demonstrating the techniques in human eyes in vivo

Corneal deformation imaging in normal eyes in vivo

Dissemination Plan

A Dissemination Plan will be prepared during the first 4 months of the project, identifying the most appropriate communication channels and tools for dissemination of key research findings related to all work-packages to a wide range of audiences.

Innovation management report

Innovation management report. This activity will be in coordination with WP8

Video clips

Short (<2 min) video clips will be made showcasing the results for the research and clinical work packages, after IP protection has been secured. The videos will be aimed at the general public, and will serve as explanatory material to potential investors in a commercialisation phase. *Months 12, 24 and 36

Press releases and media coverage

Publications in high impact journals and relevant achievements will be presented in press releases (both institutional and newsletters from academic and professional societies where project members have influence). Media coverage (television, radio, press, podcasts) is expected following press releases. Special attention will be made to seek broadcasting by European media, such as Euronews. *Months 18, 30 and 42

Project intranet in operation

The established SharePoint site will be launched, with areas for each work package, internal management, document tracking and internal communication.

Functional acoustic stimulation vibrational ps-nsOCT

Acoustic stimulation module, adapted OCT platforms

OCT platform for integration into miniaturised device and testing

OCT platform for integration into miniaturised device and testing

Functional 3D air-puff OCT imaging experimental systems

Integrated hardware and software control in OCT for acquisition of 3D corneal deformation images synchronised to air-puff.


Nanosensitive optical coherence tomography to assess wound healing within the cornea

Author(s): Cerine Lal, Sergey Alexandrov, Sweta Rani, Yi Zhou, Thomas Ritter, Martin Leahy
Published in: Biomedical Optics Express, Issue 11/7, 2020, Page(s) 3407, ISSN 2156-7085
DOI: 10.1364/BOE.389342

Corneal Properties of Keratoconus Based on Scheimpflug Light Intensity Distribution

Author(s): Alejandra Consejo, Karolina Glawdecka, Karol Karnowski, Jedrzej Solarski, Jos J. Rozema, Maciej Wojtkowski, D. Robert Iskander
Published in: Investigative Opthalmology & Visual Science, Issue 60/8, 2019, Page(s) 3197, ISSN 1552-5783
DOI: 10.1167/IOVS.19-26963

Noninvasive detection of nanoscale structural changes in cornea associated with cross‐linking treatment

Author(s): Yi Zhou, Sergey Alexandrov, Andrew Nolan, Nandan Das, Rajib Dey, Martin Leahy
Published in: Journal of Biophotonics, Issue 13/6, 2020, ISSN 1864-063X
DOI: 10.1002/jbio.201960234

Corneal tissue properties following scleral lens wear using Scheimpflug imaging

Author(s): Alejandra Consejo, David Alonso‐Caneiro, Maciej Wojtkowski, Stephen J Vincent
Published in: Ophthalmic and Physiological Optics, 2020, ISSN 0275-5408
DOI: 10.1111/opo.12710

Nanoscale structure detection and monitoring of tumour growth with optical coherence tomography

Author(s): Nandan Das, Alexandrov Sergey, Yi Zhou, Katie E. Gilligan, Róisín M. Dwyer, Martin Leahy
Published in: Nanoscale Advances, Issue 2/7, 2020, Page(s) 2853-2858, ISSN 2516-0230
DOI: 10.1039/D0NA00371A

The Role of Corneal Biomechanics for the Evaluation of Ectasia Patients

Author(s): Marcella Q. Salomão, Ana Luisa Hofling-Lima, Louise Pellegrino Gomes Esporcatte, Bernardo Lopes, Riccardo Vinciguerra, Paolo Vinciguerra, Jens Bühren, Nelson Sena, Guilherme Simões Luz Hilgert, Renato Ambrósio
Published in: International Journal of Environmental Research and Public Health, Issue 17/6, 2020, Page(s) 2113, ISSN 1660-4601
DOI: 10.3390/ijerph17062113

Keratoconus Detection Based on a Single Scheimpflug Image

Author(s): Alejandra Consejo, Jedrzej Solarski, Karol Karnowski, Jos J Rozema, Maciej Wojtkowski, D. Robert Iskander
Published in: Translational Vision Science & Technology, Issue 9/7, 2020, Page(s) 36, ISSN 2164-2591
DOI: 10.1167/tvst.9.7.36

Corneal Collagen Ordering After In Vivo Rose Bengal and Riboflavin Cross-Linking

Author(s): James A. Germann, Eduardo Martínez-Enríquez, M. Carmen Martínez-García, Irene E. Kochevar, Susana Marcos
Published in: Investigative Opthalmology & Visual Science, Issue 61/3, 2020, Page(s) 28, ISSN 1552-5783
DOI: 10.1167/iovs.61.3.28

Spatial frequency domain correlation mapping optical coherence tomography for nanoscale structural characterization

Author(s): Sergey Alexandrov, Paul M. McNamara, Nandan Das, Yi Zhou, Gillian Lynch, Josh Hogan, Martin Leahy
Published in: Applied Physics Letters, Issue 115/12, 2019, Page(s) 121105, ISSN 0003-6951
DOI: 10.1063/1.5110459

Assessment of the influence of viscoelasticity of cornea in animal ex vivo model using air-puff optical coherence tomography and corneal hysteresis

Author(s): Ewa Maczynska, Karol Karnowski, Krzysztof Szulzycki, Monika Malinowska, Hubert Dolezyczek, Artur Cichanski, Maciej Wojtkowski, Bartlomiej Kaluzny, Ireneusz Grulkowski
Published in: Journal of Biophotonics, Issue 12/2, 2019, Page(s) e201800154, ISSN 1864-063X
DOI: 10.1002/jbio.201800154

Characterization of cone size and centre in keratoconic corneas

Author(s): Ashkan Eliasy, Ahmed Abass, Bernardo T. Lopes, Riccardo Vinciguerra, Haixia Zhang, Paolo Vinciguerra, Renato Ambrósio, Cynthia J. Roberts, Ahmed Elsheikh
Published in: Journal of The Royal Society Interface, Issue 17/169, 2020, Page(s) 20200271, ISSN 1742-5689
DOI: 10.1098/rsif.2020.0271

Can the Corvis ST Estimate Corneal Viscoelasticity?

Author(s): Ahmed Abass, Cynthia J. Roberts, Bernardo Lopes, Ashkan Eliasy, Riccardo Vinciguerra, Renato Ambrósio, Paolo Vinciguerra, Ahmed Elsheikh, Mathew Francis, Himanshu Matalia, Rudy M.M.A. Nuijts, Bart Haex, Rohit Shetty, Abhijit Sinha Roy
Published in: Journal of Refractive Surgery, Issue 36/5, 2020, Page(s) 346-347, ISSN 1081-597X
DOI: 10.3928/1081597x-20200212-04

Determination of Corneal Biomechanical Behavior in-vivo for Healthy Eyes Using CorVis ST Tonometry: Stress-Strain Index

Author(s): Ashkan Eliasy, Kai-Jung Chen, Riccardo Vinciguerra, Bernardo T. Lopes, Ahmed Abass, Paolo Vinciguerra, Renato Ambrósio Jr., Cynthia J. Roberts, Ahmed Elsheikh
Published in: Frontiers in Bioengineering and Biotechnology, Issue 7, 2019, ISSN 2296-4185
DOI: 10.3389/fbioe.2019.00105

Investigation of the corneal frequency response to modulated sound excitation.

Author(s): J. S. Birkenfeld; A. Curatolo; A. Nolan; R. McAuley; A. Abass; A. Eliasy; M. Leahy; A. Elsheikh; S. Marcos
Published in: Investigative Ophthalmology & Visual Science, 2020

Assessing collagen microstructural changes in an ex vivo keratoconic eye model with Stokes polarization-sensitive optical coherence tomography

Author(s): N. Uribe-Patarroyo; J. Sophie Birkenfeld; A. Curatolo; T. M. Cannon; J. Germann; M. Villiger; S. Marcos; B. E. Bouma
Published in: Investigative Ophthalmology & Visual Science, 2020

Scleral cross-linking using Rose Bengal-Green Light

Author(s): L. I. Villegas Lopez; D. Bronte; J. Germann; S. Marcos
Published in: Investigative Ophthalmology & Visual Science, 2020

Customised optical coherence tomography system for corneal deformation imaging on multiple meridians

Author(s): A. Curatolo, J. Birkenfeld, J. A. Germann, A. de Castro, G. Muralidharan, M. Velasco, E. Martínez, and S. Marcos
Published in: 2018

Assessment of ocular mechanical resonances using phase-sensitive OCT and frequency-domain air puff stimulation

Author(s): J. Birkenfeld, A. Ramier, B. Tavakol, S. Marcos and S. Yun
Published in: 2018

Obtaining biomechanical properties of corneal tissue in-vivo using a non-contact method

Author(s): Elsheikh, A., Eliasy, A., Chen, K. J., & Vinciguerra, R.
Published in: 2018

Fluid Structure Interaction (FSI) Simulation Of the human eye under the air puff tonometry using Computational Fluid Dynamics (CFD)

Author(s): Maklad, O., Theofilis, V., & Elsheikh, A.
Published in: 2018

Intraocular Pressure Measurement Pre- and Post Refractive Surgery Using GAT and CorVis ST bIOP Algorithm

Author(s): Eliasy, A., Elsheikh, A., & Chen, K. -J.
Published in: 2018

Novel Intraocular Pressure Measurement Algorithm for Patients with Keratoconus

Author(s): Eliasy, A., Chen, K. J., Vinciguerra, R., & Elsheikh, A.
Published in: 2018

Microscopic organization of corneal collagen: Comparison between keratoconic and normal human corneas

Author(s): J. Germann, E. Martinez-Enriquez, S. Bueno, A. Mohamed, S. Nandyala, S. Chaurasia, S. Marcos
Published in: Investigative Ophthalmology & Visual Science, 2020

Probing temporal structural changes within cornea using 200 kHz swept source nano sensitive optical coherence tomography (nsOCT)

Author(s): Cerine Lal, Sergey Alexandrov, Sweta Rani, Thomas Ritter, Martin Leahy
Published in: Dynamics and Fluctuations in Biomedical Photonics XVII, 2020, Page(s) 7
DOI: 10.1117/12.2553024

Customized swept-source optical coherence tomography system for air-puff induced corneal deformation imaging on multiple meridians (Conference Presentation)

Author(s): Andrea Curatolo, Judith Birkenfeld, Eduardo Martínez, James A. Germann, Jesús Palací, Daniel Pascual, Geethika Muralidharan, Jedrzej Solarski, Karol Karnowski, Maciej Wojtkowski, Susana Marcos
Published in: Ophthalmic Technologies XXX, 2020, Page(s) 30
DOI: 10.1117/12.2546050

Detecting deformation asymmetries on multiple meridians in an ex vivo keratoconic eye model

Author(s): Andrea Curatolo; Judith Sophie Birkenfeld; Eduardo Martinez-Enriquez; James Germann; Jesus Palaci; Daniel Pascual; Geethika Muralidharan; Ashkan Eliasy; Ahmed Abass; Jedrzej Solarski; Karol Karnowski; Maciej Wojtkowski; Ahmed Elsheikh; Susana Marcos
Published in: Investigative Ophthalmology & Visual Science, 2020

Künstliche Intelligenz zur Entwicklung von Screening-Parametern im Bereich der kornealen Biomechanik

Author(s): Sven Reisdorf
Published in: Klinische Monatsblätter für Augenheilkunde, Issue 236/12, 2019, Page(s) 1423-1427, ISSN 0023-2165
DOI: 10.1055/a-1032-8559

Background Subtraction Vs Highpass filtering in phase sensitive Optica Coherence Tomography

Author(s): Ryan McAuley, A. Nolan, K. Larin, M. Singh, S. Alexandrov, Martin Leahy
Published in: Bi-annual Biophotonics and Imaging Summer School (BIGSS'18), 2018

Biomechanics of the Eye _ Chapter 6. Material properties of the human cornea: anisotropy

Author(s): Eliasy, A., Zhou, D., Studer, H., Boote, C., & Elsheikh, A.
Published in: Material properties of the human cornea: anisotropy, 2018