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Personalised Medicine by Predictive Modeling in Stroke for better Quality of Life

Objective

Stroke is one of the most severe medical problems with far-reaching public health and socio-economic impact, gathering momentum in an ageing society. PRECISE4Q sets out to minimise the burden of stroke for the individual and for society. It will create multi-dimensional data-driven predictive simulation computer models enabling – for the first time – personalised stroke treatment, addressing patient’s needs in four stages: prevention, acute treatment, rehabilitation and reintegration.
Heterogeneous data from multidisciplinary sources will be integrated: genomics, microbiomics, biochemical; imaging including mechanistic biophysiological models of brain perfusion/function; social, lifestyle, gender; economic and worklife, requiring substantial efforts for information extraction, semantic labelling and standardisation.
Novel hybrid model architectures, structured prediction models, complex deep-learning and gradient boosting models will form the Digital Stroke Patient Platform including a Stroke Risk CDSS (Clinical Decision Support System), Treatment Outcomes CDSS, Rehab Programme, Socio-Economic Planning Tool and New QvidLab. The decision support will be tailored to the patient's current life stage thus enabling clinicians to optimise prevention and treatment strategies over time, and will include personalised coping strategies, support of well-being and reintegration into social life and work.
The predictive capability and clinical precision will be validated with real clinical data generated by (i) prospective clinical studies and (ii) retrospective analyses of big data sets: health registries, cohort studies, health insurance data, electronic health records.
PRECISE4Q will have a clinically measurable and sustainable impact leading to better understanding of risk, health and resilience factors. In contrast to current schematic therapy guidelines, it will support patients throughout their life-long journey by personalised strategies for their specific needs.

Call for proposal

H2020-SC1-2017-CNECT-2
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Coordinator

CHARITE - UNIVERSITAETSMEDIZIN BERLIN
Address
Chariteplatz 1
10117 Berlin
Germany
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 276 250

Participants (12)

EMPIRICA GESELLSCHAFT FUR KOMMUNIKATIONS UND TECHNOLOGIEFORSCHUNG MBH
Germany
EU contribution
€ 567 750
Address
Oxfordstrasse 2
53111 Bonn
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
TECHNOLOGICAL UNIVERSITY DUBLIN
Ireland
EU contribution
€ 1 005 000
Address
North Circular Road 191 Park House Grangegorman
D07 EWV4 Dublin
Activity type
Higher or Secondary Education Establishments
EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
Switzerland
EU contribution
€ 467 205
Address
Raemistrasse 101
8092 Zuerich
Activity type
Higher or Secondary Education Establishments
TARTU ULIKOOL
Estonia
EU contribution
€ 366 250
Address
Ulikooli 18
51005 Tartu
Activity type
Higher or Secondary Education Establishments
FUNDACIO INSTITUT GUTTMANN
Spain
EU contribution
€ 377 190
Address
Cami De Can Ruti Sn
08916 Badalona
Activity type
Research Organisations
LINKOPINGS UNIVERSITET
Sweden
EU contribution
€ 454 225
Address
Campus Valla
581 83 Linkoping
Activity type
Higher or Secondary Education Establishments
MEDIZINISCHE UNIVERSITAT GRAZ
Austria
EU contribution
€ 240 687,50
Address
Auenbruggerplatz 2
8036 Graz
Activity type
Higher or Secondary Education Establishments
DEUTSCHES FORSCHUNGSZENTRUM FUR KUNSTLICHE INTELLIGENZ GMBH
Germany
EU contribution
€ 281 250
Address
Trippstadter Strasse 122
67663 Kaiserslautern
Activity type
Research Organisations
AOK NORDOST - DIE GESUNDHEITSKASSE
Germany
EU contribution
€ 118 750
Address
Brandenburger Strasse 72
14467 Postdam
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
QMENTA IMAGING, SL
Spain
EU contribution
€ 392 500
Address
Calle Roger De Lluria 46, Principal 1A
08009 Barcelona
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN
Ireland
EU contribution
€ 273 750
Address
Belfield
4 Dublin
Activity type
Higher or Secondary Education Establishments
UNIVERSIDAD DE MURCIA
Spain
EU contribution
€ 157 437,50
Address
Avenida Teniente Flomesta S/n - Edificio Convalecencia
30003 Murcia
Activity type
Higher or Secondary Education Establishments