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Research empowerment on solute carriers (ReSOLUTE)

Deliverables

Vector generation

Collection of lentiviral and Flp-In compatible vectors carrying CRISPR-based Cas9 and sgRNAs targeting all SLCs, together with vectors carrying tagged and untagged cDNAs for >80% of the SLC family

ReSOLUTE knowledgebase

Concept for database of integrated publicly available knowledge and ReSOLUTE web portal.

Data Mining

Data mining support for priority ranking of SLC family members for target selection in WP4.

Methodology for general detection of plasma metabolites and drug/dietary components

LC/GC-MS coupled to novel deconvolution routines for determining the approximately 3,000 molecules typically observable in serum

Data Management Plan 1

Initial version of DMP after 6 months, an updated version latest mid-term and a final version.

ReSOLUTE web portal

Data sharing and approval process, and prototype of interface for data access at public web portal up and running

ReSOLUTE database

Infrastructure and data warehouse for sharing annotated raw data files and analysis results; prototype ready after first year and annual releases of new versions.

Publications

The RESOLUTE consortium: unlocking SLC transporters for drug discovery

Author(s): Giulio Superti-Furga, Daniel Lackner, Tabea Wiedmer, Alvaro Ingles-Prieto, Barbara Barbosa, Enrico Girardi, Ulrich Goldmann, Bettina Gürtl, Kristaps Klavins, Christoph Klimek, Sabrina Lindinger, Eva Liñeiro-Retes, André C. Müller, Svenja Onstein, Gregor Redinger, Daniela Reil, Vitaly Sedlyarov, Gernot Wolf, Matthew Crawford, Robert Everley, David Hepworth, Shenping Liu, Stephen Noell, Mary Pio
Published in: Nature Reviews Drug Discovery, Issue 19/7, 2020, Page(s) 429-430, ISSN 1474-1776
DOI: 10.1038/d41573-020-00056-6

Studies of structural determinants of substrate binding in the Creatine Transporter (CreaT, SLC6A8) using molecular models

Author(s): Claire Colas, Giulia Banci, Riccardo Martini, Gerhard F. Ecker
Published in: Scientific Reports, Issue 10/1, 2020, ISSN 2045-2322
DOI: 10.1038/s41598-020-63189-z