Collection of lentiviral and Flp-In compatible vectors carrying CRISPR-based Cas9 and sgRNAs targeting all SLCs, together with vectors carrying tagged and untagged cDNAs for >80% of the SLC family
Concept for database of integrated publicly available knowledge and ReSOLUTE web portal.
Data mining support for priority ranking of SLC family members for target selection in WP4.
LC/GC-MS coupled to novel deconvolution routines for determining the approximately 3,000 molecules typically observable in serum
Initial version of DMP after 6 months, an updated version latest mid-term and a final version.
Data sharing and approval process, and prototype of interface for data access at public web portal up and running
Infrastructure and data warehouse for sharing annotated raw data files and analysis results; prototype ready after first year and annual releases of new versions.
Author(s): Giulio Superti-Furga, Daniel Lackner, Tabea Wiedmer, Alvaro Ingles-Prieto, Barbara Barbosa, Enrico Girardi, Ulrich Goldmann, Bettina Gürtl, Kristaps Klavins, Christoph Klimek, Sabrina Lindinger, Eva Liñeiro-Retes, André C. Müller, Svenja Onstein, Gregor Redinger, Daniela Reil, Vitaly Sedlyarov, Gernot Wolf, Matthew Crawford, Robert Everley, David Hepworth, Shenping Liu, Stephen Noell, Mary Pio
Published in: Nature Reviews Drug Discovery, Issue 19/7, 2020, Page(s) 429-430, ISSN 1474-1776
Author(s): Claire Colas, Giulia Banci, Riccardo Martini, Gerhard F. Ecker
Published in: Scientific Reports, Issue 10/1, 2020, ISSN 2045-2322