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Simulations for Inertial Particle Microfluidics

Simulations for Inertial Particle Microfluidics

Objective

Cancer and bacterial infections are projected to kill 18 million people worldwide annually by 2050. Fast and reliable diagnostics are essential for early and targeted treatments. Microfluidics is at the heart of the miniaturisation of diagnostics, enabling novel portable and low-cost point-of-care devices. Inertial particle microfluidics (IPMF) is a novel and competitive method with applications in cancer cell and bacteria separation. Yet, the physics behind IPMF is not well understood, making progress slow and costly. Novel design rules are in urgent need to avoid trial-and-error experiments. I will numerically investigate the underlying physical mechanisms and develop the first predictive toolkit for engineering applications of IPMF.

In particular, I will address five ambitious challenges in SIRIUS:
1. Develop an accurate numerical model for IPMF.
2. Understand the impact of particle softness.
3. Investigate the effect of finite particle concentration.
4. Improve the currently low separation efficiency of small particles.
5. Develop a toolkit to enable simulation-driven design.

These objectives are feasible through novel numerical approaches based on the lattice-Boltzmann method and state-of-the-art high-performance computing. SIRIUS will pursue an innovative simulation campaign, validated with existing experimental data, to generate both physical insight and scaling laws for simulation-driven design.

For the first time, SIRIUS will produce robust numerical methods for IPMF. My pioneering research will uncover the physics behind particle separation and culminate in a design toolkit for IPMF engineers. SIRIUS will fill a critical gap and open up an entirely new research field: “Simulations for inertial particle microfluidics”. Results of SIRIUS will be published as open-source codes, open-access articles, and open data. This will ultimately enable faster, less costly and more innovative research in the field of microfluidics for diagnostics.
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Host institution

THE UNIVERSITY OF EDINBURGH

Address

Old College, South Bridge
Eh8 9yl Edinburgh

United Kingdom

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 1 499 290

Beneficiaries (1)

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THE UNIVERSITY OF EDINBURGH

United Kingdom

EU Contribution

€ 1 499 290

Project information

Grant agreement ID: 803553

Status

Ongoing project

  • Start date

    1 January 2019

  • End date

    31 December 2023

Funded under:

H2020-EU.1.1.

  • Overall budget:

    € 1 499 290

  • EU contribution

    € 1 499 290

Hosted by:

THE UNIVERSITY OF EDINBURGH

United Kingdom