Deciphering and predicting the evolution of cancer cell populations

Informazioni relative al progetto

CANCEREVO

ID dell’accordo di sovvenzione: 820137

DOI 10.3030/820137

Data della firma CE 23 Gennaio 2019

Data di avvio 1 Marzo 2019

Data di completamento 31 Marzo 2025

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale € 2 000 000,00

Contributo UE € 2 000 000,00

Coordinato da

QUEEN MARY UNIVERSITY OF LONDON
United Kingdom

Pubblicazioni

Peer reviewed articles (5)

Mutational signatures impact the evolution of anti-EGFR antibody resistance in colorectal cancer

Autori: Andrew Woolston, Louise J. Barber, Beatrice Griffiths, Oriol Pich, Nuria Lopez-Bigas, Nik Matthews, Sheela Rao, David Watkins, Ian Chau, Naureen Starling, David Cunningham, Marco Gerlinger
Pubblicato in: Nature Ecology & Evolution, Numero 5/7, 2021, Pagina/e 1024-1032, ISSN 2397-334X
Editore: Nature Ecology and Evolution
DOI: 10.1038/s41559-021-01470-8

Circulating Tumour DNA Sequencing Identifies a Genetic Resistance-Gap in Colorectal Cancers with Acquired Resistance to EGFR-Antibodies and Chemotherapy

Autori: Franciele H. Knebel, Louise J. Barber, Alice Newey, Dimitrios Kleftogiannis, Andrew Woolston, Beatrice Griffiths, Kerry Fenwick, Fabiana Bettoni, Maurício Fernando Silva Almeida Ribeiro, Leonardo da Fonseca, Frederico Costa, Fernanda Cunha Capareli, Paulo M. Hoff, Jorge Sabbaga, Anamaria A. Camargo, Marco Gerlinger
Pubblicato in: Cancers, Numero 12/12, 2020, Pagina/e 3736, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers12123736

Detecting and Tracking Circulating Tumour DNA Copy Number Profiles during First Line Chemotherapy in Oesophagogastric Adenocarcinoma

Autori: Michael Davidson, Louise J. Barber, Andrew Woolston, Catherine Cafferkey, Sonia Mansukhani, Beatrice Griffiths, Sing-Yu Moorcraft, Isma Rana, Ruwaida Begum, Ioannis Assiotis, Nik Matthews, Sheela Rao, David Watkins, Ian Chau, David Cunningham, Naureen Starling, Marco Gerlinger
Pubblicato in: Cancers, Numero 11/5, 2019, Pagina/e 736, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers11050736

Immunopeptidomics of colorectal cancer organoids reveals a sparse HLA class I neoantigen landscape and no increase in neoantigens with interferon or MEK-inhibitor treatment

Autori: Alice Newey, Beatrice Griffiths, Justine Michaux, Hui Song Pak, Brian J. Stevenson, Andrew Woolston, Maria Semiannikova, Georgia Spain, Louise J. Barber, Nik Matthews, Sheela Rao, David Watkins, Ian Chau, George Coukos, Julien Racle, David Gfeller, Naureen Starling, David Cunningham, Michal Bassani-Sternberg, Marco Gerlinger
Pubblicato in: Journal for ImmunoTherapy of Cancer, Numero 7/1, 2019, ISSN 2051-1426
Editore: Biomedcentral
DOI: 10.1186/s40425-019-0769-8

Computational Image Analysis of T-Cell Infiltrates in Resectable Gastric Cancer: Association with Survival and Molecular Subtypes

Autori: Benjamin R Challoner, Katharina von Loga, Andrew Woolston, Beatrice Griffiths, Nanna Sivamanoharan, Maria Semiannikova, Alice Newey, Louise J Barber, David Mansfield, Lindsay C Hewitt, Yuichi Saito, Naser Davarzani, Naureen Starling, Alan Melcher, Heike I Grabsch, Marco Gerlinger
Pubblicato in: JNCI: Journal of the National Cancer Institute, Numero monthly, 2020, ISSN 0027-8874
Editore: Oxford University Press
DOI: 10.1093/jnci/djaa051