Project description
Unfolding the roots of anxiety disorders
A common psychiatric disorder, an anxiety disorder refers to irrational persistent anxiety that interferes with an individual’s daily functioning. Childhood and adolescence are the core risk phases for the development of anxiety syndromes. The EU-funded AnxNPS project aims to explain neurobiological and psychological processes related to anxiety in childhood and adolescence and investigate early experiences that may be exceptionally dangerous. This longitudinal study with the use of multimodal techniques will provide interdisciplinary insight into the relation of early-age anxiety and brain development, producing new understanding on anxiety mechanisms and a new approach for effective therapy.
Objective
Anxiety disorders are one of the most prevalent and chronic forms of psychiatric disorder. Critically, these disorders often have an early onset, with childhood and adolescence being the core period of developmental risk. Anxiety in this period can lead to academic and socio-emotional difficulties, as well as long-term mental health problems. Elucidating the developmental trajectories and aetiology of early anxiety is therefore of great importance. This project aims to further understanding of the neurobiological and psychological mechanisms through which anxiety emerges and is maintained across childhood and adolescence, as well as how atypical early social experience may increase risk. Multi-model techniques (neuroimaging, cognitive assessment, behavioural observation) incorporating interdisciplinary insights will be utilized to realize the following objectives in a longitudinal study of rhesus macaques varying in early social experience: 1) assess levels of anxiety over time; 2) track brain development over time and relate to concurrent and future anxiety; 3) assess attention bias to threat (ABT) over time and investigate its relationship with brain development and anxiety; and 4) consider effects of atypical early social experience on relationships between brain development, ABT and anxiety. Novel aspects of this project include the longitudinal investigation of brain development across the core period of risk for anxiety disorders, and consideration of how atypical early experience might modulate relationships between brain development, ABT, and anxiety. Project results will provide a more in-depth and nuanced understanding of early anxiety, which can be used to guide future human research and aid the design of more effective treatments and early interventions. Advanced training in neuroimaging and nonhuman primate behaviour will expand the candidate’s skill-set significantly, establishing their trajectory towards becoming an independent research leader.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences zoology mammalogy primatology
- medical and health sciences clinical medicine psychiatry anxiety disorders
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF-EF-ST - Standard EF
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2018
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
75794 Paris
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.