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Gene-edited T cells combating IgA Nephropathy. A blueprint approach for safe & efficient genome editing of T cells to sustainably combat several immune diseases and cancers related to B-cell pathology

Project description

Genome editing to tackle immune diseases

There is an unprecedented increase in chronic diseases due to immune imbalance for which there are limited treatment options. The EU-funded geneTIGA is developing a safe and efficient cell therapy based on genome-edited T cells to sustainably combat IgA nephropathy (IgAN), one of the most common causes of end-stage renal disease. As an IgA disease, this cell therapy approach can form the blueprint for other IgA diseases including IgA myeloma, IgA related coeliac disease and rheumatoid arthritis, as well as other Ig diseases. Thus, geneTIGA researchers anticipate the delivery of a ‘living drug’ to treat IgAN and other IgA-associated diseases for entry to first-in-human clinical trials.

Coordinator

CHARITE - UNIVERSITAETSMEDIZIN BERLIN
Net EU contribution
€ 1 696 250,00
Address
Chariteplatz 1
10117 Berlin
Germany

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Region
Berlin Berlin Berlin
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00

Participants (8)

UNIVERSITAETSKLINIKUM FREIBURG
Germany
Net EU contribution
€ 1 000 312,00
Address
Hugstetter Strasse 49
79106 Freiburg

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Region
Baden-Württemberg Freiburg Freiburg im Breisgau, Stadtkreis
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
TECHNISCHE UNIVERSITAET BRAUNSCHWEIG
Germany
Net EU contribution
€ 294 800,00
Address
Universitaetsplatz 2
38106 Braunschweig

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Region
Niedersachsen Braunschweig Braunschweig, Kreisfreie Stadt
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
OSLO UNIVERSITETSSYKEHUS HF
Norway
Net EU contribution
€ 548 125,00
Address
Kirkeveien 166 Tarnbygget
0450 Oslo

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Region
Norge Oslo og Viken Oslo
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
AARHUS UNIVERSITET
Denmark
Net EU contribution
€ 187 500,00
Address
Nordre Ringgade 1
8000 Aarhus C

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Region
Danmark Midtjylland Østjylland
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
TISSUSE GMBH
Germany
Net EU contribution
€ 872 500,00
Address
Oudenarder Strasse 16
13347 Berlin

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Berlin Berlin Berlin
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00
CHECKIMMUNE GMBH
Germany
Net EU contribution
€ 498 833,00
Address
Campus Virchow Klinikum, Cranach Haus Augustenburg Platz 1
13353 Berlin

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Berlin Berlin Berlin
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00
Europaischer Nierenpatientenverband
Austria
Net EU contribution
€ 39 908,00
Other funding
€ 0,75
INNOVATION ACTA S.R.L.
Italy
Net EU contribution
€ 598 631,00
Address
Via D.a. Azuni, 9
00196 Roma

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Centro (IT) Lazio Roma
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00

Partners (2)

EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
Switzerland
Net EU contribution
€ 0,00
Address
Raemistrasse 101
8092 Zuerich

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Region
Schweiz/Suisse/Svizzera Zürich Zürich
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom
Net EU contribution
€ 0,00
Address
Wellington Square University Offices
OX1 2JD Oxford

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Region
South East (England) Berkshire, Buckinghamshire and Oxfordshire Oxfordshire
Activity type
Higher or Secondary Education Establishments
Other funding
No data