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Metal-containing Radical Enzymes

Objective

The pharmaceutical, chemical and polymer industries are cornerstones of Europe’s economy. A key element for their transition to more sustainable processes and to innovative new compounds is biocatalysis.
Of particular interest are metallo-enzymes, i.e. proteins that host a metal cofactor. They catalyze a multitude of redox and radical reactions. To access reactions that are unknown in nature, artificial metallo-enzymes can be created. They combine the new-to-nature catalytic activity of metal complexes with the selectivity-inducing environment of the active protein site.
To develop novel biocatalysts, a highly interdisciplinary skill set is needed. MetRaZymes will create a PhD school across leading European universities that will train the next generation of scientists capable of tackling the design, development and implementation of novel enzymatic reactions in a holistic approach. It brings together computational bioscientists, bioinorganic and polymer chemists, and bioprocess engineers. Using artificial and repurposed metalloenzymes as the focal point, the ESRs will develop novel biocatalysts for radical reactions of high synthetic value, such as the late stage modification of pharmaceutical intermediates or the synthesis of polymers from renewable monomers. To train the ESRs in the needs of industrial biotechnology, the consortium includes eight of Europe´s leading pharmaceutical, chemical and enzymology companies. The ESRs will benefit from a vast transferable skills training program delivered by five training partners. Highlights include a Nature Masterclass and Wikipedia workshop. Communication partners such as Wikimedia and the Industrial Biotechnology Innovation Centre will act as muliplicators for the communication of results. Moreover, the ESRs will work with artist that use biology as their way of expression to create an ARTzymes exhibition that will foster the ERS´s creativity and result in a an unique form of science dialogue with the general public.

Coordinator

TECHNISCHE UNIVERSITAT DARMSTADT
Net EU contribution
€ 434 232,00
Address
Karolinenplatz 5
64289 Darmstadt
Germany

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Region
Darmstadt Darmstadt, Kreisfreie Stadt
Activity type
Higher or Secondary Education Establishments
Other funding
No data

Participants (6)

RIJKSUNIVERSITEIT GRONINGEN
Netherlands
Net EU contribution
€ 548 740,80
Address
Broerstraat 5
9712CP Groningen

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Region
Noord-Nederland Groningen Overig Groningen
Activity type
Higher or Secondary Education Establishments
Other funding
No data
UNIVERSITE DE STRASBOURG
France
Net EU contribution
€ 282 693,60
Address
Rue Blaise Pascal 4
67081 Strasbourg

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Region
Grand Est Alsace Bas-Rhin
Activity type
Higher or Secondary Education Establishments
Other funding
No data
UNIVERSITAET FUER BODENKULTUR WIEN
Austria
Net EU contribution
€ 360 441,60
Address
Gregor Mendel Strasse 33
1180 Wien

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Region
Wien Wien
Activity type
Higher or Secondary Education Establishments
Other funding
No data
UNIVERSITA DEGLI STUDI DI MILANO
Italy
Net EU contribution
€ 259 437,60
Address
Via Festa Del Perdono 7
20122 Milano

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Region
Nord-Ovest Lombardia Milano
Activity type
Higher or Secondary Education Establishments
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No data
UNIVERSITY OF STUTTGART
Germany
Net EU contribution
€ 260 539,20
Address
Keplerstrasse 7
70174 Stuttgart

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Region
Baden-Württemberg Stuttgart Stuttgart, Stadtkreis
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Higher or Secondary Education Establishments
Other funding
No data
TECHNISCHE UNIVERSITAT DORTMUND
Germany
Net EU contribution
€ 260 539,20
Address
August Schmidt Strasse 4
44227 Dortmund

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Region
Nordrhein-Westfalen Arnsberg Dortmund, Kreisfreie Stadt
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Higher or Secondary Education Establishments
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No data

Partners (18)

UNIVERSITAT BASEL
Switzerland
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€ 0,00
Address
Petersplatz 1
4051 Basel

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Region
Schweiz/Suisse/Svizzera Nordwestschweiz Basel-Stadt
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Higher or Secondary Education Establishments
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No data
EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
Switzerland
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€ 0,00
Address
Raemistrasse 101
8092 Zuerich

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Schweiz/Suisse/Svizzera Zürich Zürich
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Higher or Secondary Education Establishments
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No data
UNIVERSITAET BERN
Switzerland
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€ 0,00
Address
Hochschulstrasse 6
3012 Bern

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Schweiz/Suisse/Svizzera Espace Mittelland Bern / Berne
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Higher or Secondary Education Establishments
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No data
NOVOZYMES A/S
Denmark
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€ 0,00
Address
Krogshoejvej 36
2880 Bagsvaerd

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Danmark Hovedstaden Københavns omegn
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Private for-profit entities (excluding Higher or Secondary Education Establishments)
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BIOTECHNOLOGY RESEARCH AND INFORMATION NETWORK AG
Germany
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€ 0,00
Address
Darmstädter Straße 34-36
64673 Zwingenberg

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Darmstadt Bergstraße
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Private for-profit entities (excluding Higher or Secondary Education Establishments)
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No data
JOHNSON MATTHEY PLC
United Kingdom
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€ 0,00
Address
Farringdon Street 25 5th Floor
EC4A 4AB London

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London Inner London — West Camden and City of London
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Private for-profit entities (excluding Higher or Secondary Education Establishments)
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No data
BASF SE
Germany
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€ 0,00
Address
Carl Bosch Strasse 38
67063 Ludwigshafen Am Rhein

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Baden-Württemberg Stuttgart Stuttgart, Stadtkreis
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No data
NOVARTIS PHARMA AG
Switzerland
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€ 0,00
Address
Lichtstrasse 35
4056 Basel

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Schweiz/Suisse/Svizzera Nordwestschweiz Basel-Stadt
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Oxford Biotrans Limited
United Kingdom
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€ 0,00
Address
30 Upper High Street
OX9 3EZ Thame

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
South East (England) Berkshire, Buckinghamshire and Oxfordshire Oxfordshire
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NovAliX
France
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€ 0,00
Address
Boulevard Sebastien Brant Bioparc
67400 Illkirch Graffenstaden

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Grand Est Alsace Bas-Rhin
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Private for-profit entities (excluding Higher or Secondary Education Establishments)
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CORNING SAS
France
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Avenue De Valvins 7 Bis
77920 Samois Sur Seine

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Ile-de-France Ile-de-France Seine-et-Marne
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Thales-Akademie für Wirtschaft und Philosophie gemeinnützige GmbH
Germany
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€ 0,00
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Schlierbergstr.1
79100 Freiburg

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Baden-Württemberg Freiburg Freiburg im Breisgau, Stadtkreis
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Other
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SPRINGER NATURE BV
Netherlands
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€ 0,00
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Van Godewijckstraat 30
3311 GX Dordrecht

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West-Nederland Zuid-Holland Zuidoost-Zuid-Holland
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BIOFACTION KG
Austria
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€ 0,00
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Kundmanngasse 39/12
1030 Wien

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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
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Wien Wien
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Private for-profit entities (excluding Higher or Secondary Education Establishments)
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No data
Wikimedia CH
Switzerland
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€ 0,00
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Via Vedeggio 3
Lamone

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Schweiz/Suisse/Svizzera Ticino Ticino
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THE UNIVERSITY OF MANCHESTER
United Kingdom
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Oxford Road
M13 9PL Manchester

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North West (England) Greater Manchester Manchester
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FORSCHUNGSZENTRUM JULICH GMBH
Germany
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Wilhelm Johnen Strasse
52428 Julich

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Nordrhein-Westfalen Köln Düren
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UNIVERSITY OF STRATHCLYDE
United Kingdom
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Richmond Street 16
G1 1XQ Glasgow

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West Central Scotland Glasgow City
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