Project description
A closer look at kidney stone formation
Kidney stone disease is a serious and increasingly common health problem worldwide, with its prevalence linked to factors such as diet, environmental conditions, and medical issues like diabetes. The exact relationship between kidney stone formation and these factors is poorly understood, particularly how stone composition interacts with bodily fluids like urine and blood. This gap in knowledge hampers effective diagnosis and treatment. Additionally, the role of organic compounds in stone growth and dissolution remains unclear. With the support of the Marie Skłodowska-Curie Actions programme, the MiKidSton project will study a wide range of kidney stone samples. By analysing the stones from the macro to nanoscale, the project aims to identify connections to risk factors.
Objective
Kidney stone disease is a vital health problem with a significant increase in prevalence worldwide. It is known that kidney stone formation is affected by medical conditions (i.e. diabetes), environmental factors, dietary habits, and gender, although the relationship between the stone mineralogical and chemical properties (e.g. crystal structure, elemental composition, etc.) to the urine and blood parameters are still unclear. Notably, there is limited information on how the kidney stone mineral phase is influenced by the organic compounds of body fluids during growth and dissolution. Likewise, the kidney stone isotope composition will be recorded during its formation, and subsequently can be used as an indicator of dietary habits, environmental factors, and identifying underlying diseases (e.g. diabetes, osteoporosis). MiKidSton aims to perform a systematic study, from macro- to nanoscale, on a large array of different types of kidney stone samples, to assess: i) the influence of the body fluid (urine and blood) parameters, as recorded in patients, on the characteristics of kidney stone biomineral phases, ii) the relationship of the chemical/isotope composition of kidney stones to their structure, and risk factors (e.g. diet, environment, diabetes, etc.), and iii) the controlling factors for stone formation and dissolution. These objectives will be achieved combining applicant’s expertise and that of PIs, from the two host institutions, on mineralogical and isotope analyses. The outcomes will shed light on connection between kidney stone structure, composition, growth and dissolution with physiological parameters for patients with urolithiasis, with important implications for accurate diagnosis and effective treatment strategies. Finally, MiKidSton findings will have important implications for future pathological biomineral investigation using cutting-edge techniques and, most importantly, for the study of other stone-related human diseases (e.g. gallstones).
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- engineering and technology materials engineering crystals
- natural sciences chemical sciences organic chemistry
- medical and health sciences clinical medicine endocrinology diabetes
- medical and health sciences health sciences nutrition
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-GF - HORIZON TMA MSCA Postdoctoral Fellowships - Global Fellowships
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Call for proposal
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2023-PF-01
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33003 OVIEDO
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.