Project description
AI for Mg-based alloys for biodegradable, resorbable implant applications
Biomedical implants have become increasingly important in addressing various medical conditions. Biodegradable implants, particularly those based on magnesium (Mg), zinc (Zn), and iron (Fe), show promising potential. However, challenges associated with metallic implants include achieving a uniform degradation rate, managing high corrosion rates, and preventing the formation of hydrogen bubbles. Supported by the Marie Skłodowska-Curie Actions (MSCA) programme, the AIDDRI project aims to address these challenges by developing an AI-based methodology for producing Mg-based alloys suitable for biodegradable, resorbable implant applications. The results are expected to provide innovative Mg alloys with excellent performance, particularly in bone-support applications.
Objective
In recent years, the importance of biomedical implants has surged in addressing various medical conditions, including bone fractures, heart ailments, and other healthcare challenges. As healthcare complexities continue to escalate, there is a growing demand for biodegradable implants. Pioneering research in medical science is driving the scientific community toward the latest generation of biomedical implants, which closely mimic natural bone and tissues, greatly enhancing their biocompatibility. For instance, temporary medical implants are now based on biodegradable metals like magnesium (Mg), zinc (Zn), and iron (Fe), offering promising potential. Mg alloys, in particular, have a long and illustrious history, especially in bone-support applications. Their elastic modulus closely matches that of natural cortical bone, thereby reducing the occurrence of stress-shielding effects. Furthermore, the body's established pathways for excreting excess Mg via urine make Mg-based alloys ideal candidates for resorbable implants. It is anticipated that Mg-based implants will degrade within a suitable timeframe within the human body.
However, there are challenges associated with metallic implants. Firstly, achieving a uniform and predictable degradation rate of implant within the human body. Complete dissolution of the implant after fulfilling its function can provide substantial benefits to the patient by eliminating the risks and costs associated with secondary surgeries and complications, such as hypersensitivity. The second major challenge lies in using biologically safe, low-alloyed magnesium, which, unfortunately, results in high corrosion rates and the formation of hydrogen bubbles that can hinder the healing process.
To address these challenges, we propose the development of a novel methodology for producing Mg-based alloys suitable for biodegradable, resorbable implant applications, offering excellent performance.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
This project's classification has been human-validated.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
This project's classification has been human-validated.
- natural sciences computer and information sciences artificial intelligence
- engineering and technology mechanical engineering manufacturing engineering
- medical and health sciences clinical medicine surgery
- medical and health sciences medical biotechnology implants
- engineering and technology materials engineering metallurgy
Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2023-PF-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
182 00 PRAHA 8
Czechia
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.