Cel The following 2 projects represent useful additions to the current european studies on the effects of a prenatal irradiation; they may certainly also Provide new and valuable clues for the evaluations of the risks and over the cerebral mechanisms at work after very low radiation levels. 1. What is the response of a prenatally irradiated brain to an injury ? The main originality of this project by Dr. Krzysztof Janeczko (krakow) is to focus on an issue which had never been considered up to now after prenatal brain irradiations: namely, the analysis of the postnatal answer of such brains when confronted to a situation of "stress"; here, a reproducible mechanical injury.Although the project is very extensive since it proposes to consider the influence of a number of parameters (the age at irradiation, the age at injury and the radiation dose), the rationale is simple: the aim is to assess the reactions of the neuron-supporting cells (glia) at different times after a "stimulation" of the cerebral cortex (prenatally irradiated). This approach should not only allow to evaluate the nature and the adaptivity of the repair processes after in utero irradiations; it can also be expected that the response of the "stimulated" brain would reveal normally undetectable CNS dysfunctions. 2. Do very low doses of prenatal irradiation have behavioral consequences for the adult ? The project of Dr. Julia Vaglenova (Sofia) aims at this most difficult question in prenatal Radiobiology. The necessity for such research arose from the claims by Otake and Schull (Hiroshima Research Foundation epidemiological studies) over the behavioral effects (severe Mental Retardation) of prenatal radiation doses as low as 1 cGv in the atomic bomb survivors. Large scale measurements made at Mol on Rat brains have indeed confirmed that 1 cGy of 600 keV Neutrons causes brain atrophy (- 2%). However, up to now, the experimental studies claiming behavioral alterations after doses below 50 cGy remain rare and controversial. In a second leg of the proposal, Vaglenova will also test the influence of selected nootropic drugs on the behaviour of prenatal irradiated rats. Program(-y) IC-PECO/COPERNICUS - Scientific and technological cooperation between the European Community and European non-member countries, 1992- Temat(-y) 0501 - CEEC participation in NUCLEAR FISSION SAFETY programme (RADIATION PROTECTION) Zaproszenie do składania wniosków Data not available System finansowania CSC - Cost-sharing contracts Koordynator BELGIAN NUCLEAR RESEARCH CENTRE Wkład UE Brak danych Adres 200,Herrmann Debrouxlaan 40-42 1160 BRUXELLES Belgia Zobacz na mapie Koszt całkowity Brak danych Uczestnicy (1) Sortuj alfabetycznie Sortuj według wkładu UE Rozwiń wszystko Zwiń wszystko Jagellonian University Polska Wkład UE Brak danych Adres 6,Ingardena 30 060 Kraków Zobacz na mapie Koszt całkowity Brak danych
