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The co-operation of subunits in polyketide synthases

Obiettivo

Truncated versions of the erythromycin-producing polyketide synthase (PKS) will be engineered, in which specific active sites are mutated. The pattern of intersubunit protein-protein interaction in these giant multienzymes will be deduced by studying heterodimers of such mutants.

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Coordinatore

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
Contributo UE
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Indirizzo
Hills Road Addenbrooke's Hospital
CB2 2QR Cambridge
Regno Unito

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