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The co-operation of subunits in polyketide synthases

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Truncated versions of the erythromycin-producing polyketide synthase (PKS) will be engineered, in which specific active sites are mutated. The pattern of intersubunit protein-protein interaction in these giant multienzymes will be deduced by studying heterodimers of such mutants.

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THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
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Hills Road Addenbrooke's Hospital
CB2 2QR Cambridge
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