Cel An optimal immunotherapeutic regimen will be established and its efficacy evaluated in HIV-infected individuals. The proposal comprises the improvement of an adjuvant protein HIV vaccine for therapeutic use that has proved efficacious in a stringent rhesus monkey SHIV challenge rode. The irnprovement will be achieved through combination of the adjuvant protein vaccine with particle-mediated immune delivery of DNA in prime-boost immunization regimen. This regimen will be investigated in mice and rhesus monkeys for superior immunogenicity and efficacy. One or several prime-boost immunization regimen will be evaluated in initial phase I clinical trials in exonerative volunteers. If the prime-boost combinations are immunogenic, the best combination will be tested for its efficacy in a therapeutic trial in HIV-Positive patients. Dziedzina nauki medical and health sciencesbasic medicineimmunologyimmunisationnatural sciencesbiological sciencesgeneticsDNAnatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsmedical and health scienceshealth sciencesinfectious diseasesRNA virusesHIVmedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsvaccines Program(-y) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Temat(-y) 1.1.1.-2. - Key action Control of Infectious Diseases Zaproszenie do składania wniosków Data not available System finansowania CSC - Cost-sharing contracts Koordynator GLAXOSMITHKLINE BIOLOGICALS SA Wkład UE Brak danych Adres Rue de l'Institut 89 --- RIXENSART Belgia Zobacz na mapie Koszt całkowity Brak danych Uczestnicy (2) Sortuj alfabetycznie Sortuj według wkładu UE Rozwiń wszystko Zwiń wszystko FOUNDATION BIOMEDICAL PRIMATE RESEARCH CENTRE Niderlandy Wkład UE Brak danych Adres 157,Lange Kleiweg 139 2288 GJ RIJSWIJK ZH Zobacz na mapie Koszt całkowity Brak danych SWEDISH INSTITUTE FOR INFECTIOUS DISEASE CONTROL Szwecja Wkład UE Brak danych Adres Nobels vaeg 18 SOLNA Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych
