Cel The main objective is to create, to investigate and to describe mathematically a new system for unconjugated bilirubin (UB) removal from human serum albumin (HSA) containing solutions. To achieve this objective a new type of highly activated synthetic carbons (carbonic pyropolymers, CPP) will be designed and optimised for bilirubin removal. Physicochemical properties and adsorptive capacity of novel CPP to extract a wide spectrum of bioactive substances will be studied and new experimental and mathematical models of unconjugated bilirubin removal from albumin containing media will be developed.The main steps of the research program are:- Synthesis: synthesis of CPP on the base of porous vinylpyridine-styrene-divinylbenzene copolymer and phenol-formaldehyde resins and their surface modification;- Characterization of properties and mechanism of action: investigation of physicochemical properties of CPP and mechanisms of UB removal in the presence of HSA;- Bioadsorption experiments: study of adsorption capacity of CPP towards creatinine, uric acid, free fatty acids, cholic acids, phenols, proinflammatory cytokines, and other low-, middle- and high molecular mass metabolites;- Experimental modelling: development of experimental models for bilirubin removal and their in vitro testing;- Mathematical modelling: mathematical description of UB adsorption onto CPP in the presence of HSA and numerical computation of UB extraction in double-compartment model with excitations.The most important scientific results expected from this project are:1. A new type of carbonic adsorbents;2. Novel preparative procedures to optimise CPP properties for UB adsorption from HSA containing media;3. Physicochemical characterisation of newly designed CPP with adsorptive activity towards selected biologically active substances superior to alternative adsorbents;4. Determination of physicochemical mechanisms of UB adsorption onto CPP in the presence of HSA;5. Non-linear numerical model of UB removal with predictive capability for real clinical situations where "artificial liver" supporting systems are applicable.By achieving the aims and objectives of this project a major breakthrough on the way to designing an artificial liver and liver supporting systems will be made. Program(-y) IC-INTAS - International Association for the promotion of cooperation with scientists from the independent states of the former Soviet Union (INTAS), 1993- Temat(-y) 4 - Life Sciences OPEN - OPEN Call Zaproszenie do składania wniosków Data not available System finansowania Data not available Koordynator King's College, University of London Wkład UE Brak danych Adres Bessemer Road SE5 9PJ London Zjednoczone Królestwo Zobacz na mapie Koszt całkowity Brak danych Uczestnicy (5) Sortuj alfabetycznie Sortuj według wkładu UE Rozwiń wszystko Zwiń wszystko Danube University of Krems Austria Wkład UE Brak danych Adres Dr Karl Dorrek Strasse 30 3500 Krems Zobacz na mapie Koszt całkowity Brak danych Ministry of Health Rosja Wkład UE Brak danych Adres Malaya Pyrogovskaya St 1-A 119828 Moscow Zobacz na mapie Koszt całkowity Brak danych National Academy of Sciences of Ukraine Ukraina Wkład UE Brak danych Adres Vasilkovskaya Str, 45 03022 Kiev Zobacz na mapie Koszt całkowity Brak danych State University Rosja Wkład UE Brak danych Adres Institutskii Proezd 9 141700 Dolgoprudnyi, Moscow Region Zobacz na mapie Koszt całkowity Brak danych University of Brighton Zjednoczone Królestwo Wkład UE Brak danych Adres Lewes Road BN2 4GJ Brighton Zobacz na mapie Koszt całkowity Brak danych