Cel Despite the millions of deaths from tuberculosis each year and the threat of increased drug resistance, tuberculosis vaccine development has been hugely under-resourced. We set out here to evaluate the safety and immunogenicity of new subunit Constructs in Africa, a continent in desperate need of an effective tuberculosis vaccine. We shall employ two attenuated poxvirus vectors, modified virus Ankara and the FP9 adios strain that both have a marked capacity to boost pre-existing T cell responses, each expressing the secreted mycobacterium antigen, Ag85A. We shall initially test the vaccines individually at different doses and then in heterogonous prime-boost regimes to identify an immunisation regime that works well both in non-infected individuals and also in those already infected by M tuberculosis, a post-exposure vaccination group. In parallel we shall measure the incidence of tuberculosis infection and disease in various high-risk cohorts in this region to identify a group in whom tuberculosis subunit vaccines may in future be tested efficiently. Dziedzina nauki medical and health sciencesbasic medicineimmunologyimmunisationnatural sciencesbiological sciencesmicrobiologyvirologymedical and health sciencesbasic medicinepharmacology and pharmacydrug resistancemedical and health sciencesclinical medicinepneumologytuberculosismedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsvaccines Program(-y) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Temat(-y) 1.1.1.-2. - Key action Control of Infectious Diseases Zaproszenie do składania wniosków Data not available System finansowania CSC - Cost-sharing contracts Koordynator INSTITUT DE RECHERCHE POUR LE DEVELOPPEMENT Wkład UE Brak danych Adres DAKAR Senegal Zobacz na mapie Koszt całkowity Brak danych Uczestnicy (3) Sortuj alfabetycznie Sortuj według wkładu UE Rozwiń wszystko Zwiń wszystko MEDICAL RESEARCH COUNCIL Gambia Wkład UE Brak danych Adres Atlantic Boulevard 273 20 FAJARA Zobacz na mapie Koszt całkowity Brak danych THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD Zjednoczone Królestwo Wkład UE Brak danych Adres John Radcliffe Hospital - Oxfordshire 5802 OX3 9DU OXFORD/HEADINGTON Zobacz na mapie Koszt całkowity Brak danych UNIVERSITE CHEIKH ANTA DIOP DE DAKAR Senegal Wkład UE Brak danych Adres Avenue Pasteur 30 DAKAR Zobacz na mapie Koszt całkowity Brak danych
