Objective
The goal of this project is to develop qualitative and quantitative screening methods to identify and follow the fate of Se-species in Se-enriched functional foods. The interest behind the choice of selenium is driven by the state-of-the-art theoretical knowledge on its direct and indirect effects on cancer prevention that strongly depend on the given Se-species acting in in-vitro studies or in human metabolism.
Unfortunately, the actual distribution of Se-species in real world matrices is hardly known. The analysis of Se-containing or Se-enriched functional foods, a well-promoted part of innovative food products gives the possibility to analyse samples with challenging matrices and to characterise the Se-species that are putatively active in cancer prevention.
Among its main objectives the project includes the
- unambiguous identification of Se-species and their possible degradation products by the means of time-of-flight and hybrid triple quadrupole/linear ion trap mass spectrometry through accurate mass measurements and tandem MSn fragmentation studies,
- quantification of the Se-species by inductively coupled plasma mass spectrometer (ICP-MS) equipped with a collision cell,
- the synthesis of new Se-peptides for the quality control of sample preparation steps,
- time-resolved qualitative and quantitative monitoring of Se-species in selected functional food samples, ending up in the form of a database on the Se-species monitored.
An elegant method to detect and possibly identify all Se-species extracted from the samples will be the subsequent hyphenation of capillary flow HPLC separation based on reversed phase (RP) or hydrophilic interaction (HILIC) mechanisms to ICP-MS and to organic MS instrumentation.
The project will provide the possibility f or me to fully disseminate the experience gained during the initial fellowship in the field of organic mass spectrometry to the PhD and undergraduate students of the Host.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences computer and information sciences databases
- agricultural sciences agricultural biotechnology
- natural sciences chemical sciences organic chemistry amines
- natural sciences chemical sciences analytical chemistry mass spectrometry
- agricultural sciences agriculture, forestry, and fisheries agriculture grains and oilseeds cereals
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2004-MOBILITY-11
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
BUDAPEST
Hungary
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.