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Exploring Chemical Biodiversity with Innovative Approaches for Fighting Chagas and Leismaniasis

English EN

Nature holds the secret to neglected diseases therapies

A consortium of European and South American researchers has investigated novel natural products (NPs) to discover bioactive therapeutic molecules for the treatment of neglected diseases.

HEALTH

CLIMATE CHANGE AND ENVIRONMENT

DIGITAL ECONOMY

© Alexey Stiop, Thinkstock
Scientists explored biodiversity hotspots for bioactive compounds from NPs that could be used in the treatment of disease. Up to now, however, this search has somewhat neglected rare parasitic illnesses like ulcerous Leishmaniasis and Chagas disease. The EU-funded CHEMBIOFIGHT (Exploring chemical biodiversity with innovative approaches for fighting Chagas and Leismaniasis) project was set up to find novel natural products able to fight these rare conditions. This was achieved by strengthening partnerships between European and South American research organisations. Seminars, workshops and researcher exchanges ensured that the sharing of expertise and training in the use of state-of-the-art research equipment and techniques was achieved. This enabled the sharing of results and best practice. These collaborations facilitated the collection and high-throughput screening of bio-material, involving plants, marine organisms and fungi, from local biodiversity hot-spots. The novel active compounds discovered were then be characterised and tested for activity against the parasites that cause leishmaniasis and Chagas disease. Researchers also developed a computer model to predict the characteristics of potentially therapeutic compounds using data available within the consortium's chemical libraries. Over 100 different plant species from Europe and South America were collected and screened. Plant extracts were phytochemically investigated, with more than 120 compounds isolated and identified. In addition, plant extracts were analysed using dereplication and metabolomic approaches and 80 compounds were synthesized. By facilitating the mobility of researchers between the two regions, the CHEMBIOFIGHT initiative has helped to reverse the brain drain experienced in Europe and South America. It will also improve the career prospects of the researchers involved, while developing profitable academic cooperation across borders.

Keywords

Natural products, CHEMBIOFIGHT, bioactive, neglected diseases, biodiversity, ulcerous Leishmaniasis, Chagas disease, chemical libraries

Project information

Grant agreement ID: 269301

Status

Closed project

  • Start date

    1 April 2011

  • End date

    31 March 2015

Funded under:

FP7-PEOPLE

  • Overall budget:

    € 434 700

  • EU contribution

    € 434 700

Coordinated by:

ETHNIKO KAI KAPODISTRIAKO PANEPISTIMIO ATHINON