Descrizione del progetto
Composti biocompatibili ingegnerizzati a partire da microrganismi marini ed estremofili
Il progetto SECRETed, finanziato dall’UE, svilupperà nuove molecole ibride dotate di proprietà su misura attraverso una combinazione di geni biosintetici di composti amfifilici prodotti da microrganismi marini ed estremofili. I ricercatori analizzeranno varie raccolte microbiche da iniziative europee precedenti e applicheranno algoritmi di apprendimento automatico per individuare i meccanismi genetici responsabili della loro biosintesi. I cluster di geni biosintetici incaricati della produzione di queste molecole saranno sottoposti a ingegneria inversa al fine di ampliare la diversità chimica e migliorare lo sfruttamento industriale sostenibile di tali composti biocompatibili. Verranno quindi progettati, costruiti e testati nuovi ceppi in un processo iterativo per lo sviluppo di processi industriali validi e sostenibili.
Obiettivo
SECRETed is an EU-H2020 multidisciplinary project involving multiple stakeholders and with a strong participation of SMEs to fully exploit the potential of aquatic biotechnology and produce novel industrial products for the agrochemical, pharmaceutical, cosmetic and chemistry sectors. SECRETed will develop novel hybrid molecules with tailor-made properties obtained from the combination of biosynthetic genes of amphiphilic compounds (biosurfactants and siderophores) produced by marine and extremophilic microorganisms. The project will focus on reutilizing previous sampling efforts by screening already collected microbial collections from previous European initiatives. Machine Learning algorithms (ML) will be deployed to reveal the genetic mechanisms responsible for their biosynthesis and to expand the chemical diversity of such bio-based compounds. To this end, databases inspection and new collected data will be employed to construct a unique microbial amphiphilic compound chemical space comprehending molecular structures, physicochemical characteristics, associated bioactivities and revealed genetic mechanisms responsible for their biosynthesis. To expand the chemical diversity and enhance the industrial sustainable exploitation of such bio-based compounds, Biosynthetic gene clusters (BGCs) in charge of the production of these molecules will be reverse engineered by standardizing and modularizing the genetic elements comprising such clusters. Their potential benefits will be broadened by looking for Industry-driven (agrochemical, cosmetic, nutrition and health) formulations based on the engineered combinations of the genetic elements expressed in suitable microbial hosts. New strains will then be designed, built and tested in an iterative process for the development of viable and sustainable industrial processes.
Campo scientifico
Parole chiave
Programma(i)
Argomento(i)
Meccanismo di finanziamento
RIA - Research and Innovation actionCoordinatore
41300 LA RINCONADA SEVILLA
Spagna