Saturated bioisosteres of benzene and their application in drug design

Informazioni relative al progetto

BENOVELTY

ID dell’accordo di sovvenzione: 101000893

DOI

10.3030/101000893

Data della firma CE 14 Dicembre 2020

Data di avvio 1 Aprile 2021

Data di completamento 31 Marzo 2026

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale

€ 1 997 500,00

Contributo UE

€ 1 997 500,00

Coordinato da

ENAMINE LIMITED LIABILITY COMPANY,RESEARCH AND PRODUCTION ENTERPRISE
Ukraine

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I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Pubblicazioni

Peer reviewed articles (16)

Unexpected Isomerization of Oxetane-Carboxylic Acids

Autori: Bohdan Chalyk, Anastasiia Grynyova, Kateryna Filimonova, Tymofii V. Rudenko, Dmitry Dibchak, Pavel K. Mykhailiuk
Pubblicato in: Organic Letters, Numero 00027863, 2022, Pagina/e 4722–4728, ISSN 0002-7863
Editore: American Chemical Society
DOI: 10.1021/acs.orglett.2c01402

Borylated cyclobutanes <i>via</i> thermal [2 + 2]-cycloaddition

Autori: Kateryna Prysiazhniuk; Oleksandr Polishchuk; Stanislav Shulha; Kyrylo Gudzikevych; Oleksandr P. Datsenko; Vladimir Kubyshkin; Pavel K. Mykhailiuk
Pubblicato in: Chemical Science, Numero 1, 2024, Pagina/e 3249-3254, ISSN 2041-6520
Editore: Royal Society of Chemistry
DOI: 10.1039/d3sc06600b

2-Oxabicyclo[2.1.1]hexanes as saturated bioisosteres of the ortho-substituted phenyl ring

Autori: Aleksandr Denisenko, Pavel Garbuz, Nataliya M. Voloshchuk, Yuliia Holota, Galeb Al-Maali, Petro Borysko, Pavel K. Mykhailiuk
Pubblicato in: Nature Chemistry, Numero 3, 2023, Pagina/e 1155-1163, ISSN 1755-4330
Editore: Nature Publishing Group
DOI: 10.1038/s41557-023-01222-0

2-Oxabicyclo[2.1.1]hexanes: synthesis, properties and validation as bioisosteres of ortho- and meta-Benzenes

Autori: Vadym V. Levterov, Yaroslav Panasiuk, Oleh Shablykin, Oleksandr Stashkevych, Kateryna Sahun, Artur Rassokhin, Iryna Sadkova, Dmytro Lesyk, Anna Anisiforova, Yuliia Holota, Petro Borysko, Iryna Bodenchuk, Nataliya M. Voloshchuk
Pubblicato in: Angewandte Chemie International Edition, Numero 3, 2024, Pagina/e e202319831, ISSN 1433-7851
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202319831

Spiro[3.3]heptane as a Saturated Benzene Bioisostere**

Autori: Kateryna Prysiazhniuk; Oleksandr P. Datsenko; Oleksandr Polishchuk; Stanislav Shulha; Oleh Shablykin; Yelyzaveta Nikandrova; Kateryna Horbatok; Iryna Bodenchuk; Petro Borysko; Dmytro Shepilov; Iryna Pishel; Vladimir Kubyshkin; Pavel K. Mykhailiuk
Pubblicato in: Angewandte Chemie International Edition, Numero 3, 2024, Pagina/e e202316557, ISSN 1433-7851
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202316557

3‐Oxabicyclo[3.1.1]heptane as an Isostere of <i>meta</i>‐Benzene

Autori: Dmitry Dibchak, Pavel K. Mykhailiuk
Pubblicato in: Angewandte Chemie, Numero 137, 2025, Pagina/e e202505519, ISSN 0044-8249
Editore: Wiley
DOI: 10.1002/ange.202505519

General Synthesis of 3-Azabicyclo[3.1.1]heptanes and Evaluation of Their Properties as Saturated Isosteres

Autori: Dmitry Dibchak, Mariya Snisarenko, Artem Mishuk, Oleh Shablykin, Lina Bortnichuk, Oleksii Klymenko-Ulianov, Yurii Kheylik, Iryna V. Sadkova, Henry S. Rzepa, Pavel K. Mykhailiuk
Pubblicato in: Angewandte Chemie International Edition, Numero 3, 2023, Pagina/e e202304246, ISSN 1433-7851
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202304246

A Practical and Scalable Approach to Fluoro-Substituted Bicyclo[1.1.1]pentanes

Autori: Roman Bychek, Pavel K. Mykhailiuk
Pubblicato in: Angewandte Chemie International Edition, Numero 14337851, 2022, Pagina/e e202205103, ISSN 1433-7851
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202205103

Large-Scale Synthesis and Modifications of Bicyclo[1.1.1]pentane-1,3-dicarboxylic Acid (BCP)

Autori: Vasyl Ripenko, Daniil Vysochyn, Ivan Klymov, Serhii Zhersh, Pavel K. Mykhailiuk
Pubblicato in: The Journal of Organic Chemistry, Numero 00223263, 2021, Pagina/e 14061–14068, ISSN 0022-3263
Editore: American Chemical Society
DOI: 10.1021/acs.joc.1c00977

Rapid and scalable halosulfonylation of strain-release reagents

Autori: Helena D. Pickford, Vasyl Ripenko, Ryan E. McNamee, Serhii Holovchuk, Amber L. Thompson, Russell C. Smith, Pavel K. Mykhailiuk, Edward Alexander Anderson
Pubblicato in: Angewandte Chemie International Edition, Numero 14337851, 2022, Pagina/e n/a - n/a, ISSN 1433-7851
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202213508

Oxa-spirocycles: synthesis, properties and applications.

Autori: Kateryna Fominova; Taras Diachuk; Dmitry S. Granat; Taras Savchuk; Vladyslav Vilchynskyi; Oleksiy Svitlychnyi; Vladyslav Meliantsev; Igor Kovalchuk; Eduard Litskan; Vadym V. Levterov; Valentyn R. Badlo; Ruslan I. Vaskevych; Alla I. Vaskevych; Andrii V. Bolbut; Volodymyr V. Semeno; Rustam T. Iminov; Kostiantyn Shvydenko; Anastasiia S. Kuznetsova; Yurii V. Dmytriv; Yurii V. Dmytriv; Daniil Vysochyn;
Pubblicato in: Chemical Science, Numero 14737604, 2021, Pagina/e 11294-11305, ISSN 1473-7604
Editore: Royal Society of Chemistry
DOI: 10.1039/d1sc03615g

The LARGEST library of Bicyclo[1.1.1]pentanes for Drug Discovery enabled by Light

Autori: Vasyl Ripenko, Vadym Sham, Vitalina Levchenko, Serhii Holovchuk, Daniil Vysochyn, Ivan Klymov, Dmytro Kyslyi, Stanislav Veselovych, Serhii Zhersh, Yurii Dmytriv, Andrey Tolmachov, Iryna Sadkova, Irina Pishel, Pavel Mykhailiuk
Pubblicato in: ChemRxiv, Numero 5, 2023, ISSN 2573-2293
Editore: Cambridge Open Engage
DOI: 10.26434/chemrxiv-2023-8dclm

1,2-Disubstituted Bicyclo[2.1.1]hexanes as Saturated Bioisosteres of the ortho-substituted Benzene

Autori: Aleksandr Denisenko, Pavel Garbuz, Yelyzaveta Makovetska, Oleh Shablykin, Dmytro Lesyk, Galeb Al-Maali, Rodion Korzh, Iryna V. Sadkova and Pavel K. Mykhailiuk
Pubblicato in: Chemical Science, Numero 3, 2023, Pagina/e accepted, ISSN 2041-6520
Editore: Royal Society of Chemistry
DOI: 10.1039/d3sc05121h

2-Oxabicyclo[2.2.2]octane as a new bioisostere of the phenyl ring

Autori: Vadym V. Levterov, Yaroslav Panasiuk, Kateryna Sahun, Oleksandr Stashkevych, Valentyn Badlo, Oleh Shablykin, Iryna Sadkova, Lina Bortnichuk, Oleksii Klymenko-Ulianov, Yuliia Holota, Leonid Lachmann, Petro Borysko, Kateryna Horbatok, Iryna Bodenchuk, Yuliia Bas, Dmytro Dudenko, Pavel K. Mykhailiuk
Pubblicato in: Nature Communications, Numero 3, 2023, Pagina/e 5608, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-023-41298-3

https://onlinelibrary.wiley.com/doi/10.1002/anie.202311583

Autori: Alexander Kirichok, Hennadii Tkachuk, Yevhenii Kozyriev, Oleh Shablykin, Oleksandr Datsenko, Dmitry Granat, Tetyana Yegorova, Yuliya Bas, Vitalii Semirenko, Iryna Pishel, Vladimir Kubyshkin, Oleksii Klymenko-Ulianov, Dmytro Lesyk, Pavel K. Mykhailiuk
Pubblicato in: Angewandte Chemie International Edition, Numero 3, 2023, Pagina/e e202311583, ISSN 1433-7851
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202311583

Light-enabled scalable synthesis of bicyclo[1.1.1]pentane halides and their functionalizations

Autori: Vasyl Ripenko, Vadym Sham, Vitalina Levchenko, Serhii Holovchuk, Daniil Vysochyn, Ivan Klymov, Dmytro Kyslyi, Stanislav Veselovych, Serhii Zhersh, Yurii Dmytriv, Andrey Tolmachev, Iryna Sadkova, Irina Pishel, Kateryna Horbatok, Viktoria Kosach, Yelyzaveta Nikandrova, Pavel K. Mykhailiuk
Pubblicato in: Nature Synthesis, Numero 3, 2024, Pagina/e 1538-1549, ISSN 2731-0582
Editore: Springer Science and Business Media LLC
DOI: 10.1038/s44160-024-00637-y