Release of engineered extracellular vesicles for delivery of biotherapeutics

Project Information

DELIVER

Grant agreement ID: 101001374

DOI 10.3030/101001374

EC signature date 4 February 2021

Start date 1 March 2021

End date 28 February 2026

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 2 000 000,00

EU contribution € 2 000 000,00

Coordinated by

KAROLINSKA INSTITUTET
Sweden

Publications

Peer reviewed articles (7)

Tumor cell derived osteopontin and prostaglandin E2 synergistically promote the expansion of myeloid derived suppressor cells during the tumor immune escape phase.

Author(s): Doste R Mamand, Safa Bazaz, Dara K. Mohammad, Osama Saher,Oscar P.B. Wiklander, Behnam Sadeghi, Moustapha Hassan, Samir EL-Andaloussi, Manuchehr Abedi-Valugerdi.
Published in: International immunopharmacology, Issue Vol. 129, 2024, Page(s) 111584, ISSN 1567-5769
Publisher: Elsevier BV
DOI: 10.1016/j.intimp.2024.111584

The cellular response to extracellular vesicles is dependent on their cell source and dose

Author(s): Daniel W Hagey, Miina Ojansivu, Beklem R Bostancioglu, Osama Saher , Jeremy P Bost, Manuela O Gustafsson, Roberto Gramignoli, Mathias Svahn, Dhanu Gupta, Molly M Stevens , André Görgens, Samir El Andaloussi
Published in: Science Advances, Issue Vol 9 (35), 2023, Page(s) NA, ISSN 2375-2548
Publisher: AAAS
DOI: 10.1126/sciadv.adh1168

Identification of scaffold proteins for improved endogenous engineering of extracellular vesicles

Author(s): Wenyi Zheng, Julia Rädler, Helena Sork, Zheyu Zhe Niu, Samantha Roudi, Jeremy P Bost, André Görgens, Ying Zhao, Doste R Mamand, Xiuming Liang, Oscar P B Wiklander, Taavi Lehto, Dhanu Gupta, Joel Z Nordin, Samir El Andaloussi
Published in: Nature communications, Issue Vol.14 (1), 2023, Page(s) 4734-4734, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-023-40453-0

Cell‐specific targeting of extracellular vesicles though engineering the glycocalyx

Author(s): Wenyi Zheng; Rui He; Xiuming Liang; Samantha Roudi; Jeremy Bost; Pierre‐Michael Coly; Guillaume van Niel; Samir E. L. Andaloussi
Published in: Journal of extracellular vesicles, Issue Vol.11 (12), 2022, Page(s) 12290-12290, ISSN 2001-3078
Publisher: United States: Wiley
DOI: 10.1002/jev2.12290

Extracellular vesicles engineered to bind albumin demonstrate extended circulation time and lymph node accumulation in mouse models

Author(s): Xiuming Liang,Zheyu Niu,Valentina Galli,Nathalie Howe,Ying Zhao,Oscar P. B. Wiklander,Wenyi Zheng,Rim Jawad Wiklander,Giulia Corso,Christopher Davies,Justin Hean,Eleni Kyriakopoulou,Doste R. Mamand,Risul Amin,Joel Z. Nordin,Dhanu Gupta,Samir EL Andaloussi
Published in: Journal of extracellular vesicles, Issue 20013078, 2022, ISSN 2001-3078
Publisher: Hoboken: John Wiley and Sons Inc
DOI: 10.1002/jev2.12248

Amelioration of systemic inflammation via the display of two different decoy protein receptors on extracellular vesicles

Author(s): Dhanu Gupta, Oscar P. B. Wiklander, André Görgens, Mariana Conceição, Giulia Corso, Xiuming Liang, Yiqi Seow, Sriram Balusu, Ulrika Feldin, Beklem Bostancioglu, Rim Jawad, Doste R. Mamand, Yi Xin Fiona Lee, Justin Hean, Imre Mäger, Thomas C. Roberts, Manuela Gustafsson, Dara K. Mohammad, Helena Sork, Alexandra Backlund, Per Lundin, Antonin de Fougerolles, C. I. Edvard Smith, Matthew J. A. Woo
Published in: Nature biomedical engineering, Issue 2157846X, 2021, Page(s) 1084-1098, ISSN 2157-846X
Publisher: BERLIN: NATURE PORTFOLIO
DOI: 10.1038/s41551-021-00792-z

Identification of storage conditions stabilizing extracellular vesicles preparations

Author(s): André Görgens,Giulia Corso,Daniel W. Hagey,Rim Jawad Wiklander,Manuela O. Gustafsson,Ulrika Felldin,Yi Lee,R. Beklem Bostancioglu,Helena Sork,Xiuming Liang,Wenyi Zheng,Dara K. Mohammad,Simonides I. van de Wakker,Pieter Vader,Antje M. Zickler,Doste R. Mamand,Li Ma,Margaret N. Holme,Molly M. Stevens,Oscar P. B. Wiklander,Samir EL Andaloussi
Published in: Journal of extracellular vesicles, Issue 20013078, 2022, ISSN 2001-3078
Publisher: Hoboken: John Wiley and Sons Inc
DOI: 10.1002/jev2.12238

Other (1)

Exploiting the biogenesis of extracellular vesicles for bioengineering and therapeutic cargo loading

Author(s): Julia Rädler, Dhanu Gupta, Antje Zickler, Samir El Andaloussi
Published in: Molecular Therapy, Issue Vol. 31 (5), 2023, Page(s) 1231-1250
Publisher: Elsevier
DOI: 10.1016/j.ymthe.2023.02.013