Release of engineered extracellular vesicles for delivery of biotherapeutics

Publications

Tumor cell derived osteopontin and prostaglandin E2 synergistically promote the expansion of myeloid derived suppressor cells during the tumor immune escape phase.

Auteurs: Doste R Mamand, Safa Bazaz, Dara K. Mohammad, Osama Saher,Oscar P.B. Wiklander, Behnam Sadeghi, Moustapha Hassan, Samir EL-Andaloussi, Manuchehr Abedi-Valugerdi.
Publié dans: International immunopharmacology, Numéro Vol. 129, 2024, Page(s) 111584, ISSN 1567-5769
Éditeur: Elsevier BV
DOI: 10.1016/j.intimp.2024.111584

The cellular response to extracellular vesicles is dependent on their cell source and dose

Auteurs: Daniel W Hagey, Miina Ojansivu, Beklem R Bostancioglu, Osama Saher , Jeremy P Bost, Manuela O Gustafsson, Roberto Gramignoli, Mathias Svahn, Dhanu Gupta, Molly M Stevens , André Görgens, Samir El Andaloussi
Publié dans: Science Advances, Numéro Vol 9 (35), 2023, Page(s) NA, ISSN 2375-2548
Éditeur: AAAS
DOI: 10.1126/sciadv.adh1168

Identification of scaffold proteins for improved endogenous engineering of extracellular vesicles

Auteurs: Wenyi Zheng, Julia Rädler, Helena Sork, Zheyu Zhe Niu, Samantha Roudi, Jeremy P Bost, André Görgens, Ying Zhao, Doste R Mamand, Xiuming Liang, Oscar P B Wiklander, Taavi Lehto, Dhanu Gupta, Joel Z Nordin, Samir El Andaloussi
Publié dans: Nature communications, Numéro Vol.14 (1), 2023, Page(s) 4734-4734, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-023-40453-0

Cell‐specific targeting of extracellular vesicles though engineering the glycocalyx

Auteurs: Wenyi Zheng; Rui He; Xiuming Liang; Samantha Roudi; Jeremy Bost; Pierre‐Michael Coly; Guillaume van Niel; Samir E. L. Andaloussi
Publié dans: Journal of extracellular vesicles, Numéro Vol.11 (12), 2022, Page(s) 12290-12290, ISSN 2001-3078
Éditeur: United States: Wiley
DOI: 10.1002/jev2.12290

Extracellular vesicles engineered to bind albumin demonstrate extended circulation time and lymph node accumulation in mouse models

Auteurs: Xiuming Liang,Zheyu Niu,Valentina Galli,Nathalie Howe,Ying Zhao,Oscar P. B. Wiklander,Wenyi Zheng,Rim Jawad Wiklander,Giulia Corso,Christopher Davies,Justin Hean,Eleni Kyriakopoulou,Doste R. Mamand,Risul Amin,Joel Z. Nordin,Dhanu Gupta,Samir EL Andaloussi
Publié dans: Journal of extracellular vesicles, Numéro 20013078, 2022, ISSN 2001-3078
Éditeur: Hoboken: John Wiley and Sons Inc
DOI: 10.1002/jev2.12248

Amelioration of systemic inflammation via the display of two different decoy protein receptors on extracellular vesicles

Auteurs: Dhanu Gupta, Oscar P. B. Wiklander, André Görgens, Mariana Conceição, Giulia Corso, Xiuming Liang, Yiqi Seow, Sriram Balusu, Ulrika Feldin, Beklem Bostancioglu, Rim Jawad, Doste R. Mamand, Yi Xin Fiona Lee, Justin Hean, Imre Mäger, Thomas C. Roberts, Manuela Gustafsson, Dara K. Mohammad, Helena Sork, Alexandra Backlund, Per Lundin, Antonin de Fougerolles, C. I. Edvard Smith, Matthew J. A. Woo
Publié dans: Nature biomedical engineering, Numéro 2157846X, 2021, Page(s) 1084-1098, ISSN 2157-846X
Éditeur: BERLIN: NATURE PORTFOLIO
DOI: 10.1038/s41551-021-00792-z

Identification of storage conditions stabilizing extracellular vesicles preparations

Auteurs: André Görgens,Giulia Corso,Daniel W. Hagey,Rim Jawad Wiklander,Manuela O. Gustafsson,Ulrika Felldin,Yi Lee,R. Beklem Bostancioglu,Helena Sork,Xiuming Liang,Wenyi Zheng,Dara K. Mohammad,Simonides I. van de Wakker,Pieter Vader,Antje M. Zickler,Doste R. Mamand,Li Ma,Margaret N. Holme,Molly M. Stevens,Oscar P. B. Wiklander,Samir EL Andaloussi
Publié dans: Journal of extracellular vesicles, Numéro 20013078, 2022, ISSN 2001-3078
Éditeur: Hoboken: John Wiley and Sons Inc
DOI: 10.1002/jev2.12238

Exploiting the biogenesis of extracellular vesicles for bioengineering and therapeutic cargo loading

Auteurs: Julia Rädler, Dhanu Gupta, Antje Zickler, Samir El Andaloussi
Publié dans: Molecular Therapy, Numéro Vol. 31 (5), 2023, Page(s) 1231-1250
Éditeur: Elsevier
DOI: 10.1016/j.ymthe.2023.02.013

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