Release of engineered extracellular vesicles for delivery of biotherapeutics

Informacje na temat projektu

DELIVER

Identyfikator umowy o grant: 101001374

DOI

10.3030/101001374

Projekt został zamknięty

Data podpisania przez KE 4 Lutego 2021

Data rozpoczęcia 1 Marca 2021

Data zakończenia 31 Sierpnia 2026

Finansowanie w ramach

• EXCELLENT SCIENCE - European Research Council (ERC)

Koszt całkowity

€ 2 000 000,00

Wkład UE

€ 2 000 000,00

Koordynowany przez

KAROLINSKA INSTITUTET
Sweden

CORDIS oferuje możliwość skorzystania z odnośników do publicznie dostępnych publikacji i rezultatów projektów realizowanych w ramach programów ramowych HORYZONT.

Odnośniki do rezultatów i publikacji związanych z poszczególnymi projektami 7PR, a także odnośniki do niektórych konkretnych kategorii wyników, takich jak zbiory danych i oprogramowanie, są dynamicznie pobierane z systemu OpenAIRE .

Publikacje

Peer reviewed articles (25)

Injected extracellular vesicles and other nanoparticles hitchhike on erythrocytes and platelets from circulation towards organ clearance

Autorzy: Svetlana Pavlova, Doste R. Mamand, Daniel W. Hagey, Xiuming Liang, H. Yesid Estupiñán, Wenyi Zheng, Guannan Zhou, Risul Amin, Antje M. Zickler, Scott Bonner-Harris, Zankruti Dave, Miina Ojansivu, Manuela O. Gustafsson, Oliver G. Hayes, Oscar P.B. Wiklander, Manuchehr Abedi‐Valugerdi, Samantha Roudi, Antonin Marquant, Joel Z. Nordin, Molly M. Stevens, André Görgens, Samir EL Andaloussi
Opublikowane w: Extracellular Vesicle, Numer 7, 2026, Strona(/y) 100103, ISSN 2773-0417
Wydawca: Elsevier BV
DOI: 10.1016/j.vesic.2025.100103

Tumor cell derived osteopontin and prostaglandin E2 synergistically promote the expansion of myeloid derived suppressor cells during the tumor immune escape phase.

Autorzy: Doste R Mamand, Safa Bazaz, Dara K. Mohammad, Osama Saher,Oscar P.B. Wiklander, Behnam Sadeghi, Moustapha Hassan, Samir EL-Andaloussi, Manuchehr Abedi-Valugerdi.
Opublikowane w: International immunopharmacology, Numer Vol. 129, 2024, Strona(/y) 111584, ISSN 1567-5769
Wydawca: Elsevier BV
DOI: 10.1016/j.intimp.2024.111584

Engineering of extracellular vesicles for efficient intracellular delivery of multimodal therapeutics including genome editors

Autorzy: Xiuming Liang, Dhanu Gupta, Junhua Xie, Elien Van Wonterghem, Lien Van Hoecke, Justin Hean, Zheyu Niu, Marziyeh Ghaeidamini, Oscar P. B. Wiklander, Wenyi Zheng, Rim Jawad Wiklander, Rui He, Doste R. Mamand, Jeremy Bost, Guannan Zhou, Houze Zhou, Samantha Roudi, H. Yesid Estupiñán, Julia Rädler, Antje M. Zickler, André Görgens, Vicky W. Q. Hou, Radka Slovak, Daniel W. Hagey, Olivier G. de Jong
Opublikowane w: Nature Communications, Numer 16, 2025, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-025-59377-y

Development of Endogenous Protein Probes for Characterizing Surface Proteins and Cellular Interactors of Extracellular Vesicles

Autorzy: Wenyi Zheng, Metoboroghene Mowoe, Wenqing Hou, Daniel W. Hagey, Koshi Imami, Samir EL Andaloussi
Opublikowane w: Advanced Science, Numer 13, 2026, ISSN 2198-3844
Wydawca: Wiley
DOI: 10.1002/advs.202511414

Systemic Inflammation Modulates Clearance and Drives Extra‐Hepatic Distribution of Extracellular Vesicles

Autorzy: Svetlana Pavlova, Doste R. Mamand, André Görgens, Antje M. Zickler, Wenyi Zheng, Xiuming Liang, Oscar P. B. Wiklander, Manuchehr Abedi‐Valugerdi, Elien Van Wonterghem, Junhua Xie, Zheyu Niu, Samantha Roudi, Dongnan Yan, Ruhani Makkar, Guannan Zhou, Koshi Imami, Matthew J. A Wood, Roosmarijn E. Vandenbroucke, Dhanu Gupta, Samir El Andaloussi
Opublikowane w: Journal of Extracellular Vesicles, Numer 15, 2026, ISSN 2001-3078
Wydawca: Wiley
DOI: 10.1002/jev2.70256

Antibody-displaying extracellular vesicles for targeted cancer therapy

Autorzy: Oscar P. B. Wiklander, Doste R. Mamand, Dara K. Mohammad, Wenyi Zheng, Rim Jawad Wiklander, Taras Sych, Antje M. Zickler, Xiuming Liang, Heena Sharma, Andrea Lavado, Jeremy Bost, Samantha Roudi, Giulia Corso, Angus J. Lennaárd, Manuchehr Abedi-Valugerdi, Imre Mäger, Evren Alici, Erdinc Sezgin, Joel Z. Nordin, Dhanu Gupta, André Görgens, Samir EL Andaloussi
Opublikowane w: Nature Biomedical Engineering, Numer 8, 2024, Strona(/y) 1453-1468, ISSN 2157-846X
Wydawca: Springer Nature
DOI: 10.1038/s41551-024-01214-6

Genetic tools for investigating the life cycle of extracellular vesicles

Autorzy: Wenyi Zheng, Samantha Roudi, Houze Zhou, Maribel Lara Corona, Guillaume van Niel, Joel Z. Nordin, Samir EL Andaloussi
Opublikowane w: Nature Reviews Bioengineering, Numer 3, 2025, Strona(/y) 505-520, ISSN 2731-6092
Wydawca: Springer Nature
DOI: 10.1038/s44222-025-00286-6

The cellular response to extracellular vesicles is dependent on their cell source and dose

Autorzy: Daniel W Hagey, Miina Ojansivu, Beklem R Bostancioglu, Osama Saher , Jeremy P Bost, Manuela O Gustafsson, Roberto Gramignoli, Mathias Svahn, Dhanu Gupta, Molly M Stevens , André Görgens, Samir El Andaloussi
Opublikowane w: Science Advances, Numer Vol 9 (35), 2023, Strona(/y) NA, ISSN 2375-2548
Wydawca: AAAS
DOI: 10.1126/sciadv.adh1168

Formulation and Characterization of Novel Ionizable and Cationic Lipid Nanoparticles for the Delivery of Splice‐Switching Oligonucleotides

Autorzy: Miina Ojansivu, Hanna M. G. Barriga, Margaret N. Holme, Stefanie Morf, James J. Doutch, Samir EL Andaloussi, Tomas Kjellman, Markus Johnsson, Justas Barauskas, Molly M. Stevens
Opublikowane w: Advanced Materials, Numer 37, 2025, ISSN 0935-9648
Wydawca: United Nations Industrial Developement Organization
DOI: 10.1002/adma.202419538

Identification of scaffold proteins for improved endogenous engineering of extracellular vesicles

Autorzy: Wenyi Zheng, Julia Rädler, Helena Sork, Zheyu Zhe Niu, Samantha Roudi, Jeremy P Bost, André Görgens, Ying Zhao, Doste R Mamand, Xiuming Liang, Oscar P B Wiklander, Taavi Lehto, Dhanu Gupta, Joel Z Nordin, Samir El Andaloussi
Opublikowane w: Nature communications, Numer Vol.14 (1), 2023, Strona(/y) 4734-4734, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-023-40453-0

Novel Endogenous Engineering Platform for Robust Loading and Delivery of Functional mRNA by Extracellular Vesicles

Autorzy: Antje M. Zickler, Xiuming Liang, Dhanu Gupta, Doste R. Mamand, Mariacristina De Luca, Giulia Corso, Lorenzo Errichelli, Justin Hean, Titash Sen, Omnia M. Elsharkasy, Noriyasu Kamei, Zheyu Niu, Guannan Zhou, Houze Zhou, Samantha Roudi, Oscar P. B. Wiklander, André Görgens, Joel Z. Nordin, Virginia Castilla‐Llorente, Samir EL Andaloussi
Opublikowane w: Advanced Science, Numer 11, 2025, ISSN 2198-3844
Wydawca: Wiley
DOI: 10.1002/advs.202407619

Evaluation of Tetraspanins in Extracellular Vesicle Bioengineering

Autorzy: Doste R. Mamand, Oskar Gustafsson, Helena Sork, Rim Jawad Wiklander, Safa Bazaz, Xiuming Liang, Vicky W. Q. Hou, Taavi Lehto, Dhanu Gupta, André Görgens, Joel Z. Nordin, Samir E. L. Andaloussi, Oscar P. B. Wiklander
Opublikowane w: Small Science, Numer 6, 2026, ISSN 2688-4046
Wydawca: Wiley
DOI: 10.1002/smsc.202500533

Rolling Ultrasharp Microneedle Spheres Enable Topical Delivery of Biologics Through the Skin

Autorzy: Theocharis Nikiforos Iordanidis, Argyris Spyrou, Samantha Roudi, Fredrik J. Swartling, Göran Stemme, Samir EL Andaloussi, Niclas Roxhed
Opublikowane w: Advanced Healthcare Materials, Numer 14, 2025, ISSN 2192-2640
Wydawca: John Wiley and Sons Ltd
DOI: 10.1002/adhm.202500990

Imaging Single Particle Profiler to Study Nanoscale Bioparticles Using Conventional Confocal Microscopy

Autorzy: Taras Sych, André Görgens, Loïc Steiner, Gozde Gucluler, Ylva Huge, Farhood Alamdari, Markus Johansson, Firas Aljabery, Amir Sherif, Susanne Gabrielsson, Samir El Andaloussi, Erdinc Sezgin
Opublikowane w: Nano Letters, Numer 25, 2025, Strona(/y) 2173-2180, ISSN 1530-6984
Wydawca: American Chemical Society
DOI: 10.1021/acs.nanolett.4c05117

Cell‐specific targeting of extracellular vesicles though engineering the glycocalyx

Autorzy: Wenyi Zheng; Rui He; Xiuming Liang; Samantha Roudi; Jeremy Bost; Pierre‐Michael Coly; Guillaume van Niel; Samir E. L. Andaloussi
Opublikowane w: Journal of extracellular vesicles, Numer Vol.11 (12), 2022, Strona(/y) 12290-12290, ISSN 2001-3078
Wydawca: United States: Wiley
DOI: 10.1002/jev2.12290

Extracellular vesicles engineered to bind albumin demonstrate extended circulation time and lymph node accumulation in mouse models

Autorzy: Xiuming Liang,Zheyu Niu,Valentina Galli,Nathalie Howe,Ying Zhao,Oscar P. B. Wiklander,Wenyi Zheng,Rim Jawad Wiklander,Giulia Corso,Christopher Davies,Justin Hean,Eleni Kyriakopoulou,Doste R. Mamand,Risul Amin,Joel Z. Nordin,Dhanu Gupta,Samir EL Andaloussi
Opublikowane w: Journal of extracellular vesicles, Numer 20013078, 2022, ISSN 2001-3078
Wydawca: Hoboken: John Wiley and Sons Inc
DOI: 10.1002/jev2.12248

Amelioration of systemic inflammation via the display of two different decoy protein receptors on extracellular vesicles

Autorzy: Dhanu Gupta, Oscar P. B. Wiklander, André Görgens, Mariana Conceição, Giulia Corso, Xiuming Liang, Yiqi Seow, Sriram Balusu, Ulrika Feldin, Beklem Bostancioglu, Rim Jawad, Doste R. Mamand, Yi Xin Fiona Lee, Justin Hean, Imre Mäger, Thomas C. Roberts, Manuela Gustafsson, Dara K. Mohammad, Helena Sork, Alexandra Backlund, Per Lundin, Antonin de Fougerolles, C. I. Edvard Smith, Matthew J. A. Woo
Opublikowane w: Nature biomedical engineering, Numer Vol.5 (9), 2021, Strona(/y) 1084-1098, ISSN 2157-846X
Wydawca: BERLIN: NATURE PORTFOLIO
DOI: 10.1038/s41551-021-00792-z

Multimeric Conjugates Using Engineered Peptide Scaffolds for Efficient siRNA Delivery

Autorzy: Quentin Vicentini, Dennis Hekman, Deepak Bhatt, Rouven Stulz, Mahya Dezfouli, Peter Gennemark, Nicola Guzzi, Naoko Toki, Bojana Lazovic, Carolina Tängemo, Shalini Andersson, Samir EL Andaloussi, Anders Dahlén
Opublikowane w: Bioconjugate Chemistry, Numer 36, 2025, Strona(/y) 1299-1310, ISSN 1043-1802
Wydawca: American Chemical Society
DOI: 10.1021/acs.bioconjchem.5c00156

Amphipathic Octenyl‐Alanine Modified Peptides Mediate Effective siRNA Delivery

Autorzy: Tõnis Lehto, Marit Isakannu, Helena Sork, Annely Lorents, Safa Bazaz, Oscar P. B. Wiklander, Samir EL Andaloussi, Taavi Lehto
Opublikowane w: Journal of Peptide Science, Numer 31, 2025, ISSN 1075-2617
Wydawca: John Wiley & Sons Inc.
DOI: 10.1002/psc.70054

Bioengineered Extracellular Vesicles Mitigate Neuroinflammation by Neutralizing Pneumolysin and Delaying Disease Onset in Experimental Pneumococcal Meningitis

Autorzy: Kristine Farmen, Doste R. Mamand, Miguel Tofiño‐Vian, Georgia Yfanti, Xiuming Liang, Houze Zhou, Vicky W. Q. Hou, Samir El Andaloussi, Oscar P. B. Wiklander, Federico Iovino
Opublikowane w: Journal of Extracellular Vesicles, Numer 15, 2026, ISSN 2001-3078
Wydawca: Wiley
DOI: 10.1002/jev2.70369

Design and screening of novel endosomal escape compounds that enhance functional delivery of oligonucleotides in vitro

Autorzy: H. Yesid Estupiñán, Tom Baladi, Samantha Roudi, Michael J. Munson, Jeremy Bost, Oskar Gustafsson, Daniel Velásquez-Ramírez, Deepak Kumar Bhatt, Daniel Hagey, Dennis Hekman, Shalini Andersson, Samir EL Andaloussi, Anders Dahlén
Opublikowane w: Molecular Therapy Nucleic Acids, Numer 36, 2025, Strona(/y) 102522, ISSN 2162-2531
Wydawca: Nature Publishing Group
DOI: 10.1016/j.omtn.2025.102522

Identification of robust and abundant reference transcripts for EV mRNA cargo normalization

Autorzy: Antje M. Zickler, Radosław Grochowski, André Görgens, Erik Bäcklin, Maximilian Kordes, J.-Matthias Löhr, Joel Z. Nordin, Samir EL Andaloussi, Daniel W. Hagey
Opublikowane w: Extracellular Vesicle, Numer 5, 2025, Strona(/y) 100065, ISSN 2773-0417
Wydawca: Elsevier BV
DOI: 10.1016/j.vesic.2025.100065

Screening scaffold proteins for improved functional delivery of luminal proteins using engineered extracellular vesicles

Autorzy: Zheyu Niu, Houze Zhou, Wenyi Zheng, Oliver G. Hayes, Vicky W.Q. Hou, André Görgens, Samantha Roudi, Guannan Zhou, Rim Jawad Wiklander, Taras Sych, Erdinc Sezgin, Joel Z. Nordin, Ying Zhao, Xiuming Liang, Samir E.L. Andaloussi
Opublikowane w: Journal of Controlled Release, Numer 384, 2026, Strona(/y) 113882, ISSN 0168-3659
Wydawca: Elsevier BV
DOI: 10.1016/j.jconrel.2025.113882

Identification of storage conditions stabilizing extracellular vesicles preparations

Autorzy: André Görgens,Giulia Corso,Daniel W. Hagey,Rim Jawad Wiklander,Manuela O. Gustafsson,Ulrika Felldin,Yi Lee,R. Beklem Bostancioglu,Helena Sork,Xiuming Liang,Wenyi Zheng,Dara K. Mohammad,Simonides I. van de Wakker,Pieter Vader,Antje M. Zickler,Doste R. Mamand,Li Ma,Margaret N. Holme,Molly M. Stevens,Oscar P. B. Wiklander,Samir EL Andaloussi
Opublikowane w: Journal of extracellular vesicles, Numer Vol.11 (6), 2022, ISSN 2001-3078
Wydawca: Hoboken: John Wiley and Sons Inc
DOI: 10.1002/jev2.12238

Advanced peptide nanoparticles enable robust and efficient delivery of gene editors across cell types

Autorzy: Oskar Gustafsson, Supriya Krishna, Sophia Borate, Marziyeh Ghaeidamini, Xiuming Liang, Osama Saher, Raul Cuellar, Björn K. Birdsong, Samantha Roudi, H. Yesid Estupiñán, Evren Alici, C.I. Edvard Smith, Elin K. Esbjörner, Simone Spuler, Olivier Gerrit de Jong, Helena Escobar, Joel Z. Nordin, Samir E.L. Andaloussi
Opublikowane w: Journal of Controlled Release, Numer 386, 2026, Strona(/y) 114038, ISSN 0168-3659
Wydawca: Elsevier BV
DOI: 10.1016/j.jconrel.2025.114038

Thesis and dissertations (2)

RNAi delivery platforms : bioconjugates and extracellular vesicles

Autorzy: Julia Rädler
Opublikowane w: 2026, ISBN 978-91-8141-113-3
Wydawca: Karolinska Institutet
DOI: 10.69622/31959393

In vivo and in situ delivery of biotherapeutics for improved extrahepatic bioavailability

Autorzy: Samantha Roudi
Opublikowane w: 2026, ISBN 978-91-8141-150-8
Wydawca: Karolinska Institutet
DOI: 10.69622/32315469

Other (1)

Exploiting the biogenesis of extracellular vesicles for bioengineering and therapeutic cargo loading

Autorzy: Julia Rädler, Dhanu Gupta, Antje Zickler, Samir El Andaloussi
Opublikowane w: Molecular Therapy, Numer Vol. 31 (5), 2023, Strona(/y) 1231-1250
Wydawca: Elsevier
DOI: 10.1016/j.ymthe.2023.02.013