Release of engineered extracellular vesicles for delivery of biotherapeutics

Pubblicazioni

Tumor cell derived osteopontin and prostaglandin E2 synergistically promote the expansion of myeloid derived suppressor cells during the tumor immune escape phase.

Autori: Doste R Mamand, Safa Bazaz, Dara K. Mohammad, Osama Saher,Oscar P.B. Wiklander, Behnam Sadeghi, Moustapha Hassan, Samir EL-Andaloussi, Manuchehr Abedi-Valugerdi.
Pubblicato in: International immunopharmacology, Numero Vol. 129, 2024, Pagina/e 111584, ISSN 1567-5769
Editore: Elsevier BV
DOI: 10.1016/j.intimp.2024.111584

The cellular response to extracellular vesicles is dependent on their cell source and dose

Autori: Daniel W Hagey, Miina Ojansivu, Beklem R Bostancioglu, Osama Saher , Jeremy P Bost, Manuela O Gustafsson, Roberto Gramignoli, Mathias Svahn, Dhanu Gupta, Molly M Stevens , André Görgens, Samir El Andaloussi
Pubblicato in: Science Advances, Numero Vol 9 (35), 2023, Pagina/e NA, ISSN 2375-2548
Editore: AAAS
DOI: 10.1126/sciadv.adh1168

Identification of scaffold proteins for improved endogenous engineering of extracellular vesicles

Autori: Wenyi Zheng, Julia Rädler, Helena Sork, Zheyu Zhe Niu, Samantha Roudi, Jeremy P Bost, André Görgens, Ying Zhao, Doste R Mamand, Xiuming Liang, Oscar P B Wiklander, Taavi Lehto, Dhanu Gupta, Joel Z Nordin, Samir El Andaloussi
Pubblicato in: Nature communications, Numero Vol.14 (1), 2023, Pagina/e 4734-4734, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-023-40453-0

Cell‐specific targeting of extracellular vesicles though engineering the glycocalyx

Autori: Wenyi Zheng; Rui He; Xiuming Liang; Samantha Roudi; Jeremy Bost; Pierre‐Michael Coly; Guillaume van Niel; Samir E. L. Andaloussi
Pubblicato in: Journal of extracellular vesicles, Numero Vol.11 (12), 2022, Pagina/e 12290-12290, ISSN 2001-3078
Editore: United States: Wiley
DOI: 10.1002/jev2.12290

Extracellular vesicles engineered to bind albumin demonstrate extended circulation time and lymph node accumulation in mouse models

Autori: Xiuming Liang,Zheyu Niu,Valentina Galli,Nathalie Howe,Ying Zhao,Oscar P. B. Wiklander,Wenyi Zheng,Rim Jawad Wiklander,Giulia Corso,Christopher Davies,Justin Hean,Eleni Kyriakopoulou,Doste R. Mamand,Risul Amin,Joel Z. Nordin,Dhanu Gupta,Samir EL Andaloussi
Pubblicato in: Journal of extracellular vesicles, Numero 20013078, 2022, ISSN 2001-3078
Editore: Hoboken: John Wiley and Sons Inc
DOI: 10.1002/jev2.12248

Amelioration of systemic inflammation via the display of two different decoy protein receptors on extracellular vesicles

Autori: Dhanu Gupta, Oscar P. B. Wiklander, André Görgens, Mariana Conceição, Giulia Corso, Xiuming Liang, Yiqi Seow, Sriram Balusu, Ulrika Feldin, Beklem Bostancioglu, Rim Jawad, Doste R. Mamand, Yi Xin Fiona Lee, Justin Hean, Imre Mäger, Thomas C. Roberts, Manuela Gustafsson, Dara K. Mohammad, Helena Sork, Alexandra Backlund, Per Lundin, Antonin de Fougerolles, C. I. Edvard Smith, Matthew J. A. Woo
Pubblicato in: Nature biomedical engineering, Numero 2157846X, 2021, Pagina/e 1084-1098, ISSN 2157-846X
Editore: BERLIN: NATURE PORTFOLIO
DOI: 10.1038/s41551-021-00792-z

Identification of storage conditions stabilizing extracellular vesicles preparations

Autori: André Görgens,Giulia Corso,Daniel W. Hagey,Rim Jawad Wiklander,Manuela O. Gustafsson,Ulrika Felldin,Yi Lee,R. Beklem Bostancioglu,Helena Sork,Xiuming Liang,Wenyi Zheng,Dara K. Mohammad,Simonides I. van de Wakker,Pieter Vader,Antje M. Zickler,Doste R. Mamand,Li Ma,Margaret N. Holme,Molly M. Stevens,Oscar P. B. Wiklander,Samir EL Andaloussi
Pubblicato in: Journal of extracellular vesicles, Numero 20013078, 2022, ISSN 2001-3078
Editore: Hoboken: John Wiley and Sons Inc
DOI: 10.1002/jev2.12238

Exploiting the biogenesis of extracellular vesicles for bioengineering and therapeutic cargo loading

Autori: Julia Rädler, Dhanu Gupta, Antje Zickler, Samir El Andaloussi
Pubblicato in: Molecular Therapy, Numero Vol. 31 (5), 2023, Pagina/e 1231-1250
Editore: Elsevier
DOI: 10.1016/j.ymthe.2023.02.013

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