Peptide Killers of Bacteria

Project Information

PeptideKillers

Grant agreement ID: 101001470

DOI

10.3030/101001470

EC signature date 25 May 2021

Start date 1 January 2022

End date 31 December 2026

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 315 705,00

EU contribution

€ 2 315 705,00

Coordinated by

Masarykova univerzita
Czechia

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Conference proceedings (1)

HOW LARGE MOLECULES CAN ENTER CELL

Author(s): Sukeník Lukáš; Deb Rahul; Vácha Robert
Published in: Czech Chemical Society Symposium Series - Annual meeting of the National Institute of Virology and Bacteriology (NIVB), Issue 3, 2022, Page(s) 368
Publisher: National Institute of Virology and Bacteriology

Peer reviewed articles (13)

Insertases scramble lipids: Molecular simulations of MTCH2

Author(s): Ladislav Bartoš, Anant K. Menon, Robert Vácha
Published in: Structure, Issue 32, 2024, Page(s) 505-510.e4, ISSN 0969-2126
Publisher: Cell Press
DOI: 10.1016/j.str.2024.01.012

Pathways to a Shiny Future: Building the Foundation for Computational Physical Chemistry and Biophysics in 2050

Author(s): Denys Biriukov, Robert Vácha
Published in: ACS Physical Chemistry Au, Issue 4, 2024, Page(s) 302-313, ISSN 2694-2445
Publisher: ASC Publications
DOI: 10.1021/acsphyschemau.4c00003

Enhanced diffusion through multivalency

Author(s): Ladislav Bartoš, Mikael Lund, Robert Vácha
Published in: Soft Matter, Issue 21, 2025, Page(s) 179-185, ISSN 1744-683X
Publisher: Royal Society of Chemistry
DOI: 10.1039/d4sm00778f

Optimizing properties of translocation-enhancing transmembrane proteins

Author(s): Ladislav Bartoš, Martina Drabinová, Robert Vácha
Published in: Biophysical Journal, Issue 123, 2024, Page(s) 1240-1252, ISSN 0006-3495
Publisher: Biophysical Society
DOI: 10.1016/j.bpj.2024.04.009

Sequence and structural determinants of RNAPII CTD phase-separation and phosphorylation by CDK7

Author(s): Katerina Linhartova, Francesco Luca Falginella, Martin Matl, Marek Sebesta, Robert Vácha, Richard Stefl
Published in: Nature Communications, Issue 15, 2024, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-024-53305-2

Binding of DEP domain to phospholipid membranes: More than just electrostatics

Author(s): Francesco L. Falginella, Marek Kravec, Martina Drabinová, Petra Paclíková, Vítĕzslav Bryja, Robert Vácha
Published in: Biochimica et Biophysica Acta (BBA) - Biomembranes, Issue Volume 1864, Issue 10, 1 October 2022, 2022, Page(s) 1-12, ISSN 0005-2736
Publisher: Elsevier BV
DOI: 10.1016/j.bbamem.2022.183983

Magainin 2 and PGLa in bacterial membrane mimics IV: Membrane curvature and partitioning

Author(s): Enrico F. Semeraro, Peter Pajtinka, Lisa Marx, Ivo Kabelka, Regina Leber, Karl Lohner, Robert Vácha, Georg Pabst
Published in: BIOPHYSICAL JOURNAL, Issue Volume 121, Issue 23, 6 December 2022, 2022, Page(s) 4689-4701, ISSN 0006-3495
Publisher: Biophysical Society
DOI: 10.1016/j.bpj.2022.10.018

Amphipathic Helices Can Sense Both Positive and Negative Curvatures of Lipid Membranes

Author(s): Peter Pajtinka, Robert Vácha
Published in: The Journal of Physical Chemistry Letters, Issue 15, 2024, Page(s) 175-179, ISSN 1948-7185
Publisher: American Chemical Society
DOI: 10.1021/acs.jpclett.3c02785

Phospholipids are imported into mitochondria by VDAC, a dimeric beta barrel scramblase

Author(s): Helene Jahn, Ladislav Bartoš, Grace I. Dearden, Jeremy S. Dittman, Joost C. M. Holthuis, Robert Vácha, Anant K. Menon
Published in: Nature Communications, Issue 14, 2023, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-023-43570-y

Membrane Adsorption Enhances Translocation of Antimicrobial Peptide Buforin 2

Author(s): Mehrnoosh Khodam Hazrati, Robert Vácha
Published in: The Journal of Physical Chemistry B, Issue 128, 2024, Page(s) 8469-8476, ISSN 1520-6106
Publisher: American Chemical Society
DOI: 10.1021/acs.jpcb.4c04338

Computational Design of Pore-Forming Peptides with Potent Antimicrobial and Anticancer Activities

Author(s): Rahul Deb, Marcelo D. T. Torres, Miroslav Boudný, Markéta Koběrská, Floriana Cappiello, Miroslav Popper, Kateřina Dvořáková Bendová, Martina Drabinová, Adelheid Hanáčková, Katy Jeannot, Miloš Petřík, Maria Luisa Mangoni, Gabriela Balíková Novotná, Marek Mráz, Cesar de la Fuente-Nunez, Robert Vácha
Published in: Journal of Medicinal Chemistry, Issue 67, 2024, Page(s) 14040-14061, ISSN 0022-2623
Publisher: American Chemical Society
DOI: 10.1021/acs.jmedchem.4c00912

Nanoparticle induced fusion of lipid membranes

Author(s): Sofía Blasco, Lukáš Sukeník, Robert Vácha
Published in: Nanoscale, Issue 16, 2024, Page(s) 10221-10229, ISSN 2040-3364
Publisher: Royal Society of Chemistry
DOI: 10.1039/d4nr00591k

Peptide translocation across asymmetric phospholipid membranes

Author(s): Ladislav Bartoš, Robert Vácha
Published in: Biophysical Journal, Issue 123, 2024, Page(s) 693-702, ISSN 0006-3495
Publisher: Biophysical Society
DOI: 10.1016/j.bpj.2024.02.006

Non-peer reviewed articles (1)

Design guidelines for α-helical peptides that self-assemble into transmembrane barrel pores killing antibiotic-resistant bacteria

Author(s): Rahul Deb; Ivo Kabelka; Jan Přibyl; Edo Vreeker; Giovanni Maglia; Robert Vácha
Published in: bioRxiv, Issue 1, 2022, ISSN 2692-8205
Publisher: bioRxiv
DOI: 10.1101/2022.05.09.491086