Weight Maintenance by AgRP neurons

Informazioni relative al progetto

Yoyo-LepReSens

ID dell’accordo di sovvenzione: 101002247

DOI

10.3030/101002247

Data della firma CE 30 Aprile 2021

Data di avvio 1 Settembre 2021

Data di completamento 31 Agosto 2027

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale

€ 1 999 976,00

Contributo UE

€ 1 999 976,00

Coordinato da

HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH
Germany

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Pubblicazioni

Peer reviewed articles (11)

GLP-1R–GIPR–PPARα/γ/δ quintuple agonism corrects obesity and diabetes in mice

Autori: Daniela Liskiewicz, Aaron Novikoff, Ahmed Khalil, Seun Akindehin, Jonathan E. Campbell, Pietra Candela, Russell L. Castelino, Callum Coupland, Maxime Culot, W. Scott Dodson, Jonathan D. Douros, Hannes Embring, Annette Feuchtinger, Brian Finan, Cristina Garcia-Caceres, Xiao-Bing Gao, Fabien Gosselet, Gerald Grandl, Robert M. Gutgesell, Daniel T. Haas, Martin Jastroch, Ezgi Karaoglu, Pamela Kakimoto
Pubblicato in: Nature, Numero 653, 2026, Pagina/e 776-785, ISSN 0028-0836
Editore: Nature Publishing Group
DOI: 10.1038/s41586-026-10427-5

The serine protease KLK7 promotes immune cell infiltration in visceral adipose tissue in obesity

Autori: Aleix Ribas-Latre, Anne Hoffmann, Claudia Gebhardt, Juliane Weiner, Lilli Arndt, Nora Raulien, Martin Gericke, Adhideb Ghosh, Kerstin Krause, Nora Klöting, Paul T. Pfluger, Bilal N. Sheikh, Thomas Ebert, Anke Tönjes, Michael Stumvoll, Christian Wolfrum, Matthias Blüher, Ulf Wagner, Joan Vendrell, Sonia Fernández-Veledo, John T. Heiker
Pubblicato in: Metabolism, Numero 168, 2026, Pagina/e 156239, ISSN 0026-0495
Editore: Elsevier BV
DOI: 10.1016/j.metabol.2025.156239

Adipocyte-derived extracellular vesicles increase insulin secretion through transport of insulinotropic protein cargo

Autori: Konxhe Kulaj, Alexandra Harger, Michaela Bauer, Özüm S. Caliskan, Tilak Kumar Gupta, Dapi Menglin Chiang, Edward Milbank, Josefine Reber, Angelos Karlas, Petra Kotzbeck, David N. Sailer, Francesco Volta, Dominik Lutter, Sneha Prakash, Juliane Merl-Pham, Vasilis Ntziachristos, Hans Hauner, Michael W. Pfaffl, Matthias H. Tschöp, Timo D. Müller, Stefanie M. Hauck, Benjamin D. Engel, Jantje M. Ger
Pubblicato in: Nature Communications, 2023, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-023-36148-1

HDAC5 controls a hypothalamic STAT5b-TH axis, the sympathetic activation of ATP-consuming futile cycles and adult-onset obesity in male mice

Autori: Raian E. Contreras, Tim Gruber, Ismael González-García, Sonja C. Schriever, Meri De Angelis, Noemi Mallet, Miriam Bernecker, Beata Legutko, Dhiraj Kabra, Mathias Schmidt, Matthias H. Tschöp, Ruth Gutierrez-Aguilar, Jane Mellor, Cristina García-Cáceres, Paul T. Pfluger
Pubblicato in: Molecular Metabolism, Numero 90, 2024, Pagina/e 102033, ISSN 2212-8778
Editore: Elsevier GmbH
DOI: 10.1016/j.molmet.2024.102033

Loss of GIPR in LEPR cells impairs glucose control by GIP and GIP:GLP-1 co-agonism without affecting body weight and food intake in mice

Autori: Seun Akindehin, Arkadiusz Liskiewicz, Daniela Liskiewicz, Miriam Bernecker, Cristina Garcia-Caceres, Daniel J Drucker, Brian Finan, Gerald Grandl, Robert Gutgesell, Susanna M Hofmann, Ahmed Khalil, Xue Liu, Perla Cota, Mostafa Bakhti, Oliver Czarnecki, Aimée Bastidas-Ponce, Heiko Lickert, Lingru Kang, Gandhari Maity, Aaron Novikoff, Sebastian Parlee, Ekta Pathak, Sonja C Schriever, Michael Sterr,
Pubblicato in: Molecular Metabolism, 2023, ISSN 2212-8778
Editore: Elsevier GmbH
DOI: 10.1016/j.molmet.2024.101915

Weight cycling exacerbates glucose intolerance and hepatic triglyceride storage in mice with a history of chronic high fat diet exposure

Autori: Miriam Bernecker, Anna Lin, Annette Feuchtinger, Anna Molenaar, Sonja C. Schriever, Paul T. Pfluger
Pubblicato in: Journal of Translational Medicine, Numero 23, 2025, ISSN 1479-5876
Editore: BioMed Central
DOI: 10.1186/s12967-024-06039-0

Estradiol regulates leptin sensitivity to control feeding via hypothalamic Cited1

Autori: Ismael González-García, Elena García-Clavé, Alberto Cebrian-Serrano, Ophélia Le Thuc, Raian E. Contreras, Yanjun Xu, Tim Gruber, Sonja C. Schriever, Beata Legutko, Jutta Lintelmann, Jerzy Adamski, Wolfgang Wurst, Timo D. Müller, Stephen C. Woods, Paul T. Pfluger, Matthias H. Tschöp, Alexandre Fisette, Cristina García-Cáceres
Pubblicato in: Cell Metabolism, 2023, ISSN 1550-4131
Editore: Cell Press
DOI: 10.1016/j.cmet.2023.02.004

Low-moderate dosed cranial irradiation in young mice induces sex specific metabolic disturbances later in life

Autori: Luke Harrison, Sonja C. Schriever, Miriam Bernecker, Noemi Mallet, Cristina Mencias Castillejo, Hamid Ameli, Peter Baumann, Raian E. Contreras, Jessica Stolz, Rainer Lindner, Stefan Bartzsch, Thomas E. Schmid, Stephanie E. Combs, Michael Rosemann, Paul T. Pfluger
Pubblicato in: Diabetes, 2025, ISSN 0012-1797
Editore: American Diabetes Association
DOI: 10.2337/figshare.29618474.v1

A Novel mechanism for depot-specific leptin gene expression regulation and its persistence after weight loss

Autori: Natalie Taege, Jan Hendric Britsemmer, Andreas Israel, Christin Krause, Sina Junge, Annette Feuchtinger, Siegfried Ussar, Paul Thomas Pfluger, Timo Gemoll, Sonja Charlotte Schriever, Henriette Kirchner
Pubblicato in: iScience, Numero 29, 2026, Pagina/e 115101, ISSN 2589-0042
Editore: Elsevier BV
DOI: 10.1016/j.isci.2026.115101

A novel tamoxifen-inducible Mct8-CreERT2 mouse model for targeted studies of Mct8-expressing cells and thyroid hormone transport and function

Autori: Anna Molenaar, Noémi Mallet, Marin Bralo, Luciano J. Hoeher, Sonja C. Schriever, Ekta Pathak, Miriam Bernecker, Timo D. Müller, Ali Ertürk, Alberto Cebrian-Serrano, Paul T. Pfluger
Pubblicato in: Transgenic Research, Numero 34, 2025, ISSN 0962-8819
Editore: Chapman & Hall
DOI: 10.1007/s11248-025-00471-8

Liver microRNA transcriptome reveals miR-182 as link between type 2 diabetes and fatty liver disease in obesity

Autori: Christin Krause, Jan H. Britsemmer, Miriam Bernecker, Anna Molenaar, Natalie Taege, Nuria Lopez-Alcantara, Cathleen Geißler, Meike Kaehler, Katharina Iben, Anna Judycka, Jonas Wagner, Stefan Wolter, Oliver Mann, Paul T. Pfluger, Ingolf Cascorbi, Hendrik Lehnert, Kerstin Stemmer, Sonja C. Schriever, Henriette Kirchner
Pubblicato in: elife, 2024, ISSN 2050-084X
Editore: eLife Sciences Publications
DOI: 10.7554/elife.92075.2

Non-peer reviewed articles (1)

Distinct gene signatures of human intermuscular adipose tissue expansion visualized by spatial transcriptomics in mice

Autori: Ekta Pathak, Robby Z. Tom, Myeongseop Kim, Stephan Sachs, Yao Zhang, Marc Walter, Paul T. Pfluger, Annette Feuchtinger, Ken A. Dyar, Bryan C. Bergman, Miguel A. Pleitez, Dominik Lutter, Susanna M. Hofmann
Pubblicato in: MedRxiv, 2026, ISSN 3067-2007
Editore: medRxiv
DOI: 10.64898/2026.04.16.26351017

Conference proceedings (1)

Central Actions of Leptin Sensitizer Celastrol

Autori: Miriam Bernecker, Sonja Schriever, Ekta Pathak, Michael Sterr, Heiko Lickert, Jessica Yue, Paul Pfluger
Pubblicato in: Endocrine Abstracts, 2023, ISSN 0804-4643
Editore: European journal of endocrinology
DOI: 10.1530/endoabs.90.p79