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Novel mechanisms of adaptive and innate bacteriophage immunity

Publicaciones

Modulating CRISPR-Cas genome editing using guide-complementary DNA oligonucleotides

Autores: Thomas Swartjes; Peng Shang; Dennis van den Berg; Tim A. Künne; Niels Geijsen; Stan J.J. Brouns; John van der Oost; Raymond H.J. Staals; Richard A. Notebaart
Publicado en: The CRISPR Journal, 2022, ISSN 2573-1599
Editor: Mary Ann Liebert
DOI: 10.1101/2022.01.15.475214

Structural basis for broad anti-phage immunity by DISARM

Autores: Jack P. K. Bravo; Cristian Aparicio-Maldonado; Franklin L. Nobrega; Stan J. J. Brouns; David W. Taylor
Publicado en: Nature Communications, 2022, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1101/2021.12.26.474123

Phage tRNAs evade tRNA-targeting host defenses through anticodon loop mutations

Autores: Daan F. van den Berg; Baltus A. van der Steen; Ana Rita Costa; Stan J. J. Brouns
Publicado en: eLife, 2023, ISSN 2050-084X
Editor: eLife Sciences Publications
DOI: 10.21203/rs.3.rs-2166710/v1

Craspase is a CRISPR RNA-guided, RNA-activated protease

Autores: Chunyi Hu; Sam P. B. van Beljouw; Ki Hyun Nam; Gabriel Schuler; Fran Ding; Yanru Cui; Alicia Rodríguez-Molina; Anna C. Haagsma; Menno Valk; Martin Pabst; Stan J. J. Brouns; Ailong Ke
Publicado en: Science, 2022, ISSN 0036-8075
Editor: American Association for the Advancement of Science
DOI: 10.1126/science.add5064

Single cell variability of CRISPR‐Cas interference and adaptation

Autores: Rebecca E McKenzie, Emma M Keizer, Jochem N A Vink, Jasper van Lopik, Ferhat Büke, Vera Kalkman, Christian Fleck, Sander J Tans, Stan J J Brouns
Publicado en: Molecular Systems Biology, 2022, ISSN 1744-4292
Editor: Nature Publishing Group
DOI: 10.15252/msb.202110680

An OmpW-dependent T4-like phage infects Serratia sp. ATCC 39006

Autores: Marina Mahler; Lucia M. Malone; Daan F. van den Berg; Leah M. Smith; Stan J. J. Brouns; Peter C. Fineran
Publicado en: Microbial Genomics, 2023, ISSN 2057-5858
Editor: London Society for General Microbiology
DOI: 10.1099/mgen.0.000968

Short prokaryotic Argonaute systems trigger cell death upon detection of invading DNA

Autores: Balwina Koopal; Ana Potocnik; Sumanth K. Mutte; Cristian Aparicio-Maldonado; Simon Lindhoud; Jacques J.M. Vervoort; Stan J.J. Brouns; Daan C. Swarts
Publicado en: Cell, 2022, ISSN 1097-4172
Editor: Cell press
DOI: 10.1016/j.cell.2022.03.012

Mechanisms and clinical importance of bacteriophage resistance.

Autores: Julia E Egido; Ana Rita Costa; Ana Rita Costa; Cristian Aparicio-Maldonado; Cristian Aparicio-Maldonado; Pieter-Jan A. Haas; Stan J. J. Brouns; Stan J. J. Brouns
Publicado en: FEMS Microbiology Reviews, 2022, ISSN 1574-6976
Editor: Elsevier
DOI: 10.1093/femsre/fuab048

CasPEDIA Database: a functional classification system for class 2 CRISPR-Cas enzymes

Autores: Benjamin A Adler; Marena I Trinidad; Daniel Bellieny-Rabelo; Elaine Zhang; Hannah M Karp; Petr Skopintsev; Brittney W Thornton; Rachel F Weissman; Peter H Yoon; LinXing Chen; Tomas Hessler; Amy R Eggers; David Colognori; Ron Boger; Erin E Doherty; Connor A Tsuchida; Ryan V Tran; Laura Hofman; Honglue Shi; Kevin M Wasko; Zehan Zhou; Chenglong Xia; Muntathar J Al-Shimary; Jaymin R Patel; Vienna C J
Publicado en: Nucleic Acids Research, 2023, ISSN 1362-4962
Editor: Oxford University Press
DOI: 10.1093/nar/gkad890

The gRAMP CRISPR-Cas effector is an RNA endonuclease complexed with a caspase-like peptidase.

Autores: Sam P. B. van Beljouw; Sam P. B. van Beljouw; Anna C. Haagsma; Anna C. Haagsma; Alicia Rodríguez-Molina; Alicia Rodríguez-Molina; Daan F. van den Berg; Daan F. van den Berg; Jochem N.A. Vink; Jochem N.A. Vink; Stan J. J. Brouns; Stan J. J. Brouns
Publicado en: Science, 2021, ISSN 0036-8075
Editor: American Association for the Advancement of Science
DOI: 10.1126/science.abk2718

Adaptation by Type V-A and V-B CRISPR-Cas Systems Demonstrates Conserved Protospacer Selection Mechanisms Between Diverse CRISPR-Cas Types

Autores: Wen Y. Wu; Simon A. Jackson; Cristóbal Almendros; Anna C. Haagsma; Suzan Yilmaz; Gerrit Gort; John van der Oost; Stan J.J. Brouns; Raymond H.J. Staals
Publicado en: The CRISPR Journal, 2022, ISSN 2573-1602
Editor: Mary Ann Liebert
DOI: 10.1089/crispr.2021.0150

PAM-repeat associations and spacer selection preferences in single and co-occurring CRISPR-Cas systems.

Autores: Jochem N.A. Vink; Jochem N.A. Vink; Jan H. L. Baijens; Jan H. L. Baijens; Stan J. J. Brouns; Stan J. J. Brouns
Publicado en: Genome Biology, 2021, ISSN 1474-760X
Editor: London BioMed Central
DOI: 10.1186/s13059-021-02495-9

Monitoring phage-induced lysis of Gram-negatives in real time using a fluorescent DNA dye

Autores: Julia E. Egido; Catherine Toner-Bartelds; Ana Rita Costa; Stan J. J. Brouns; Suzan H. M. Rooijakkers; Bart W. Bardoel; Pieter-Jan Haas
Publicado en: Scientific Reports, 2023, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-023-27734-w

High-resolution reconstruction of a Jumbo-bacteriophage infecting capsulated bacteria using hyperbranched tail fibers

Autores: Ruochen Ouyang; Ana Rita Costa; C. Keith Cassidy; Aleksandra Otwinowska; Vera C. J. Williams; Agnieszka Latka; Phill J. Stansfeld; Zuzanna Drulis-Kawa; Yves Briers; Daniël M. Pelt; Stan J. J. Brouns; Ariane Briegel
Publicado en: Nature Communications, 2022, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-022-34972-5

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