Rapid interaction profiling of 2019-nCoV for network-based deep drug-repurpose learning (DDRL)

Informazioni relative al progetto

RiPCoN

ID dell’accordo di sovvenzione: 101003633

DOI

10.3030/101003633

Progetto chiuso

Data della firma CE 2 Aprile 2020

Data di avvio 1 Aprile 2020

Data di completamento 31 Gennaio 2024

Finanziato da

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Costo totale

€ 1 230 635,00

Contributo UE

€ 1 230 635,00

Coordinato da

HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH
Germany

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Data sets, microdata, etc (8)

Co-complex CoHIN

complex binary interactome: high-quality protein complex interaction for 2019- nCoV and selected other coronaviral proteins with human host proteins

Integrated human CoHIN

Task 4.1: network integration and pathway identification Integrate the experimental and computation network data with human reference interactome network data. Subsequently identify pathway enrichment and other statistics to obtain leads about additional perturbations by 2019-nCoVTask 4.2: topological and network module identification – perform graph theoretical and network analyses to determine the network communities, topological features and other characteristics of virally targeted host proteins

Predicted PPI/PRI CoHIN

validation data for all experimental interactome datasets

Validated experimtl. CoHIN

Deliverable-1-4, validation data for all experimental interactome datasets

Experiment. Validated pred. CoHIN

Deliverable-2-3, experimentally validated predicted protein-protein coronavirus-host interactome

Primary binary CoHIN

Deliverable-1-1, primary binary interactome: high-quality primary interaction for all coronaviral proteins with human host proteins

Allele risk association

Deliverable-3-3, human and viral variants increasing or decreasing disease severity risk

Allele Interaction Matrix

Deliverable-3-2, virus-host protein variant interaction matrix

Other (5)

mimicINT webserver

MimicINT computational pipeline - webserver integration

ß-CoV ORFeome

Deliverable-1-2, -CoV ORFeome, ORF reagents for functional experiments by other researchers that require protein expression

Variant ORFs

Deliverable41 fully integrated fully validated coronavirushuman interactome network map

Initial Drug Validation

Deliverable61 test results for at least 10 topranked predicted already approved drugs

Novel small molecules evaluation

Deliverable-6-2, test results for at least 10 top-ranked novel small molecules

Open Research Data Pilot (2)

Data Sharing Plan

Data Sharing Plan All data relevant combating the current health emergency will be communicated to the commission and policy makers as soon as available.

Update of DPM

First data release and update to DPM

Documents, reports (2)

Manuscripts

Primary Interactive Manuscript(s) in month 15/16 and in month 36

CoHIN Manuscript

Pubblicazioni

Peer reviewed articles (10)

Bioactivity Profile Similarities to Expand the Repertoire of COVID-19 Drugs

Autori: Miquel Duran-Frigola, Martino Bertoni, Roi Blanco, Víctor Martínez, Eduardo Pauls, Víctor Alcalde, Gemma Turon, Núria Villegas, Adrià Fernández-Torras, Carles Pons, Lídia Mateo, Oriol Guitart-Pla, Pau Badia-i-Mompel, Aleix Gimeno, Nicolas Soler, Isabelle Brun-Heath, Hugo Zaragoza, Patrick Aloy
Pubblicato in: Journal of Chemical Information and Modeling, Numero 60/12, 2020, Pagina/e 5730-5734, ISSN 1549-9596
Editore: American Chemical Society
DOI: 10.1021/acs.jcim.0c00420

A resource of human coronavirus protein-coding sequences in a flexible, multipurpose Gateway Entry clone collection

Autori: Benjamin Weller 1 , Chung-Wen Lin 1 , Oxana Pogoutse 2 3 4 5 , Mayra Sauer 1 , Nora Marin-de la Rosa 1 , Alexandra Strobel 1 , Veronika Young 1 , Jennifer J Knapp 2 3 4 5 , Ashyad Rayhan 2 3 4 5 , Claudia Falter 1 , Dae-Kyum Kim 2 3 4 5 6 , Frederick P Roth 2 3 4 5 7 , Pascal Falter-Braun 1 8
Pubblicato in: G3 - Genes, Genomes, Genetics, 2023, ISSN 2160-1836
Editore: Genetics Society of America
DOI: 10.1093/g3journal/jkad105

A Community Challenge for Pancancer Drug Mechanism of Action Inference from Perturbational Profile Data

Autori: Douglass, Eugene F.; Allaway, Robert J.; Szalai, Bence; Wang, Wenyu; Tian, Tingzhong; Fernández-Torras, Adrià; Realubit, Ron; Karan, Charles; Zheng, Shuyu; Pessia, Alberto; Tanoli, Ziaurrehman; Jafari, Mohieddin; Wan, Fangping; Li, Shuya; Xiong, Yuanpeng; Duran-Frigola, Miquel; Bertoni, Martino; Badia-i-Mompel, Pau; Mateo, Lídia; Guitart-Pla, Oriol; Chung, Verena; Tang, Jing; Zeng, Jianyang; Al
Pubblicato in: Cell Reports Medicine, Numero 7, 2022, ISSN 2666-3791
Editore: Elsevier
DOI: 10.1016/j.xcrm.2021.100492

The intricacy of the viral-human protein interaction networks: resources, data and analyses

Autori: Saha D, Iannuccielli M, Brun C, Zanzoni A, Licata L
Pubblicato in: Frontiers in Microbiology, 2022, ISSN 1664-302X
Editore: Frontiers Media
DOI: 10.3389/fmicb.2022.849781

Long-COVID-19: the persisting imprint of SARS-CoV-2 infections on the innate immune system

Autori: Marianne Boes 1 , Pascal Falter-Braun 2 3
Pubblicato in: Signal Transduction and Targeted Therapy, 2023, ISSN 2059-3635
Editore: Springer Nature
DOI: 10.1038/s41392-023-01717-9

Bioactivity descriptors for uncharacterized compounds

Autori: Martino Bertoni; Miquel Duran-Frigola; Pau Badia-i-Mompel; Eduardo Pauls; Modesto Orozco-Ruiz; Oriol Guitart-Pla; Víctor Alcalde; Víctor M. Díaz; Antoni Berenguer-Llergo; Antonio García de Herreros; Patrick Aloy
Pubblicato in: Nature Communications, Numero 12, 2021, Pagina/e 3932, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1101/2020.07.21.214197

BQsupports: systematic assessment of the support and novelty of new biomedical associations.

Autori: Adrià Fernández-Torras, Martina Locatelli, Martino Bertoni, Patrick Aloy
Pubblicato in: Bioinformatics, Numero Volume 39, Numero 9, September 2023, 2023, ISSN 1367-4811
Editore: Oxford Univeristy Press
DOI: 10.1093/bioinformatics/btad581

Integrating and formatting biomedical data as pre-calculated knowledge graph embeddings in the Bioteque

Autori: Adrià Fernández-Torras; Miquel Duran-Frigola; Martino Bertoni; Martina Locatelli; Patrick Aloy
Pubblicato in: Nature Communications, 2022, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-022-33026-0

Connecting chemistry and biology through molecular descriptors.

Autori: Adrià Fernández-Torras; Arnau Comajuncosa-Creus; Miquel Duran-Frigola; Patrick Aloy
Pubblicato in: Current Opinion in Chemical Biology, Numero 1, 2022, ISSN 1367-5931
Editore: Elsevier BV
DOI: 10.1016/j.cbpa.2021.09.001

A proteome-scale map of the SARS-CoV-2–human contactome

Autori: Dae-Kyum Kim, Benjamin Weller, Chung-Wen Lin, Dayag Sheykhkarimli, Jennifer J. Knapp, Guillaume Dugied, Andreas Zanzoni, Carles Pons, Marie J. Tofaute, Sibusiso B. Maseko, Kerstin Spirohn, Florent Laval, Luke Lambourne, Nishka Kishore, Ashyad Rayhan, Mayra Sauer, Veronika Young, Hridi Halder, Nora Marín-de la Rosa, Oxana Pogoutse, Alexandra Strobel, Patrick Schwehn, Roujia Li, Simin T. Rothballer
Pubblicato in: Nature Biotechnology, 2023, ISSN 1546-1696
Editore: Springer Nature
DOI: 10.1038/s41587-022-01475-z

Conference proceedings (1)

Probing SARS-CoV-2 RNA interactome to unravel post-transcriptional dysregulation associated with COVID-19

Autori: Saha D, Ribeiro D, Zanzoni A, Brun C.
Pubblicato in: Proceeding of JOBIM'22 (Journées Ouvertes Biologie Informatique Mathématiques), Numero Yearly, 2022
Editore: SFBI (Société Française de Bioinformatique)