The consortium established 7 science education clusters in 4 countries (Cyprus, Greece, Poland, Portugal). This supportive network for schools based on partnerships with universities, research centres, laboratories, enterprises, associations, and civil society representatives, enriched education in STEM disciplines (Science, Technology, Engineering, Mathematics). The school-based activities described in the 73 educational scenarios developed by the consortium contributed to students’ knowledge, competence and literacy in health issues with high public health impact, with a focus on diseases that are influenced by socioeconomic determinants and require individual and global community action. The partners activities focused on creating workable arrangements for open schooling, where organisations provide a significant contribution to formal education providers and benefit from students’ engagement and preparation on real life challenges connected with public health, while promoting teacher professional development and teaching-learning innovations that involve community stakeholders in supporting the school on the implementation of the educational scenarios. The public health challenges launched within the designed digital educational scenarios engaged students in inquiry-based projects that require collaborative work with the stakeholders, increase citizens literacy and benefit the health of the community. The project involved about 114.278 students (12-15 years old) in the project activities and provided professional development actions for 5.709 teachers. Major results/outcomes of PAFSE: i) Public awareness on the role of Science Education for Responsible Citizenship; ii) Positive attitudes towards Science and informed decisions regarding STEM curricula and careers; iii) Specialised resources and expertise from researchers to teachers and students; iv) Educational methodology for STEM Education; v) Digital Educational Scenarios and Learning Objects for Science Education; vi) Support of teachers in the adaption of educational scenarios to the local level and particularities of the school; vii) Case studies reporting the design, development and validation of educational scenarios; viii) School Project Management Resources and Scientific Inquiry Instruments for inquiry-based learning; ix) Actions of formal and informal science education in schools as well as through multiple stakeholders like universities and enterprises; x) Active involvement of the students in pressing issues connected to individual and community health; xi) Active involvement of the students in societal problems with local impact; xii) Open schooling events for enhancing the dialogue between students, teachers, parents, and wider community; xiii) Guidelines for the implementation of the open schooling framework; xiv) A toolkit for open schooling enhancing the dialogue between students, students and teachers, students and their community; xv) Web-based Educational Resource Repository for hosting learning objects – Photodentro PAFSE repository; xvi) Web-based interactive virtual educational environment for networking, collaboration and communication – E-me platform; xvii) Teachers training courses/professional development workshops; xviii) Opportunities of schools for continued/sustainable dialogue and collaborations with universities/ scientific community.