Innovations to accelerate vaccine development and manufacture

Informazioni relative al progetto

Inno4Vac

ID dell’accordo di sovvenzione: 101007799

DOI

10.3030/101007799

Data della firma CE 19 Luglio 2021

Data di avvio 1 Settembre 2021

Data di completamento 28 Febbraio 2027

Finanziato da

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Costo totale

€ 39 342 552,00

Contributo UE

€ 18 600 000,00

Coordinato da

EUROPEAN VACCINE INITIATIVE E.V
Germany

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Documents, reports (6)

Scientific consensus docon new challenge influenza strains
Roadmap document prioritizing RSV immune assays for development and standardization
Report of regulatory workshop 1
Prepare SOPs for handling open calls process
Workshops with stakeholders implemented
Open call process launched

Other (1)

Launch of web site

Pubblicazioni

Non-peer reviewed articles (4)

Training data composition determines machine learning generalization and biological rule discovery

Autori: Eugen Ursu, Aygul Minnegalieva, Puneet Rawat, Maria Chernigovskaya, Robi Tacutu, Geir Kjetil Sandve, Philippe A. Robert, Victor Greiff
Pubblicato in: bioRxiv, 2024, ISSN 2692-8205
Editore: Cold Spring Harbor Laboratory
DOI: 10.1101/2024.06.17.599333

Simulation of adaptive immune receptors and repertoires with complex immune information to guide the development and benchmarking of AIRR machine learning

Autori: Maria Chernigovskaya, Milena Pavlović, Chakravarthi Kanduri, Sofie Gielis, Philippe A. Robert, Lonneke Scheffer, Andrei Slabodkin, Ingrid Hobæk Haff, Pieter Meysman, Gur Yaari, Geir Kjetil Sandve, Victor Greiff
Pubblicato in: bioRxiv, 2023, ISSN 2692-8205
Editore: Cold Spring Harbor Laboratory
DOI: 10.1101/2023.10.20.562936

Weakly supervised identification and generation of adaptive immune receptor sequences associated with immune disease status

Autori: Andrei Slabodkin, Ludvig M. Sollid, Geir Kjetil Sandve, Philippe A. Robert, Victor Greiff
Pubblicato in: bioRxiv, 2024, ISSN 2692-8205
Editore: Cold Spring Harbor Laboratory
DOI: 10.1101/2023.09.24.558823

InSilicoSeq 2.0: Simulating realistic amplicon-based sequence reads

Autori: Stefan H. Lelieveld, Thijs Maas, Tessa C. X. Duk, Hadrien Gourlé, Henk-Jan van den Ham
Pubblicato in: bioRxiv, 2024, ISSN 2692-8205
Editore: Cold Spring Harbor Laboratory
DOI: 10.1101/2024.02.16.580469

Other (2)

modsim/CADET: Version 4.4.0

Autori: Samuel Leweke, Johannes Schmölder, Eric von Lieres, Jayghosh Rao, Jazib Hassan, William Heymann, Jan Breuer, Jonathan Rocher, & Salah Azzouzi
Pubblicato in: 2023, ISSN 1082-9873
Editore: Zenodo
DOI: 10.5281/zenodo.8179016

Advancing In Silico Tools for Vaccine Development and Process Modeling

Autori: Irina Meln, Gunnveig Grødeland, Daniel G. Bracewell, Meta Roestenberg, Cécile van Els, Kimberly Veenstra and Ole Olesen
Pubblicato in: BioProcess International, 2022
Editore: Informa Connect Limited

Peer reviewed articles (11)

Fourth Controlled Human Infection Model (CHIM) meeting – CHIMs in endemic countries, May 22–23, 2023

Autori: Melissa Kapulu, Lucinda Manda-Taylor, Shobana Balasingam, Gary Means, Mikal Ayiro Malungu, Philip Bejon, Primus Che Chi, Christopher Chiu, E. Chandler Church, Rodrigo Correa-Oliveira, Nicholas Day, Anna Durbin, Moses Egesa, Claudia Emerson, Kondwani Jambo, Roli Mathur, Wolfram Metzger, Noni Mumba, Winfred Nazziwa, Ally Olotu, Jacqueline Rodgers, Frank Sinyiza, Kawsar Talaat, Ingrid Kamerling, Char
Pubblicato in: Biologicals, Numero 85, 2024, Pagina/e 101747, ISSN 1045-1056
Editore: Academic Press
DOI: 10.1016/j.biologicals.2024.101747

Solving crystallization/precipitation population balance models in CADET, part I: Nucleation growth and growth rate dispersion in batch and continuous modes on nonuniform grids

Autori: Wendi Zhang, Todd Przybycien, Johannes Schmölder, Samuel Leweke, Eric von Lieres
Pubblicato in: Computers & Chemical Engineering, Numero 183, 2024, Pagina/e 108612, ISSN 0098-1354
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.compchemeng.2024.108612

Benchmarking and integrating human B-cell receptor genomic and antibody proteomic profiling

Autori: Khang Lê Quý, Maria Chernigovskaya, Maria Stensland, Sachin Singh, Jinwoo Leem, Santiago Revale, David A. Yadin, Francesca L. Nice, Chelsea Povall, Danielle H. Minns, Jacob D. Galson, Tuula A. Nyman, Igor Snapkow, Victor Greiff
Pubblicato in: npj Systems Biology and Applications, Numero 10, 2024, ISSN 2056-7189
Editore: Springer Nature
DOI: 10.1038/s41540-024-00402-z

Biophysical cartography of the native and human-engineered antibody landscapes quantifies the plasticity of antibody developability

Autori: Habib Bashour, Eva Smorodina, Matteo Pariset, Jahn Zhong, Rahmad Akbar, Maria Chernigovskaya, Khang Lê Quý, Igor Snapkow, Puneet Rawat, Konrad Krawczyk, Geir Kjetil Sandve, Jose Gutierrez-Marcos, Daniel Nakhaee-Zadeh Gutierrez, Jan Terje Andersen, Victor Greiff
Pubblicato in: Communications Biology, Numero 7, 2024, ISSN 2399-3642
Editore: Springer Nature
DOI: 10.1038/s42003-024-06561-3

Organ-on-chip models for infectious disease research

Autori: Raquel Alonso-Roman, Alexander S. Mosig, Marc Thilo Figge, Kai Papenfort, Christian Eggeling, Felix H. Schacher, Bernhard Hube, Mark S. Gresnigt
Pubblicato in: Nature Microbiology, Numero 9, 2024, Pagina/e 891-904, ISSN 2058-5276
Editore: Nature Microbiology
DOI: 10.1038/s41564-024-01645-6

Accelerating vaccine manufacturing development through model-based approaches: current advances and future opportunities

Autori: Elham Ramin, Antonio Gaetano Cardillo, Reinhard Liebers, Johannes Schmölder, Eric von Lieres, Wim Van Molle, Bastian Niebel, Laurent Natalis, Irina Meln, Mónica Perea-Vélez, Didier Clénet, John Bagterp Jørgensen, Bernt Nilsson, Daniel G. Bracewell, Krist V. Gernaey
Pubblicato in: Current Opinion in Chemical Engineering, Numero 43, 2024, Pagina/e 100998, ISSN 2211-3398
Editore: Elsevier BV
DOI: 10.1016/j.coche.2023.100998

Regulatory workshop on challenge strain development and GMP manufacture – A stakeholder meeting report

Autori: Nicoletta Corti, Christopher Chiu, Rebecca J. Cox, Clarisse Demont, Jeanne-Marie Devaster, Othmar G. Engelhardt, Andrew Gorringe, Khaole Hassan, Marcel Hoefnagel, Ingrid Kamerling, Oleg Krut, Chelsea Lane, Reinhard Liebers, Catherine Luke, Wim Van Molle, Sandra Morel, Pieter Neels, Meta Roestenberg, Michelle Rubbrecht, Wiep Klaas Smits, Daniel Stoughton, Kawsar Talaat, Maria J.G.T. Vehreschild, Ad
Pubblicato in: Biologicals, Numero 85, 2024, Pagina/e 101746, ISSN 1045-1056
Editore: Academic Press
DOI: 10.1016/j.biologicals.2024.101746

Ethical approval for controlled human infectious model clinical trial protocols – A workshop report

Autori: Euzebiusz Jamrozik, Katherine Littler, Irina Meln, Wim Van Molle, Sandra Morel, Ole F. Olesen, Michelle Rubbrecht, Shobana Balasingam, Pieter Neels
Pubblicato in: Biologicals, Numero 85, 2024, Pagina/e 101748, ISSN 1045-1056
Editore: Academic Press
DOI: 10.1016/j.biologicals.2024.101748

Spatial discontinuous Galerkin spectral element method for a family of chromatography models in CADET

Autori: Jan Michael Breuer, Samuel Leweke, Johannes Schmölder, Gregor Gassner, Eric von Lieres
Pubblicato in: Computers & Chemical Engineering, 2023, Pagina/e 108340, ISSN 0098-1354
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.compchemeng.2023.108340

Fourth Controlled Human Infection Model (CHIM) meeting, CHIM regulatory issues, May 24, 2023

Autori: Marco Cavaleri, David Kaslow, Eric Boateng, Wilbur H. Chen, Christopher Chiu, Robert K.M. Choy, Rodrigo Correa-Oliveira, Anna Durbin, Moses Egesa, Malick Gibani, Melissa Kapulu, Melba Katindi, Ally Olotu, Pongphaya Pongsuwan, Michelo Simuyandi, Bruno Speder, Kawsar R. Talaat, Charlie Weller, Bridget Wills, Marc Baay, Shobana Balasingam, Ole F. Olesen, Pieter Neels
Pubblicato in: Biologicals, Numero 85, 2024, Pagina/e 101745, ISSN 1045-1056
Editore: Academic Press
DOI: 10.1016/j.biologicals.2024.101745

Immunocompetent PDMS‐Free Organ‐on‐Chip Model of Cervical Cancer Integrating Patient‐Specific Cervical Fibroblasts and Neutrophils

Autori: Elena Kromidas, Alicia Geier, Adrian Weghofer, Hui‐Yu Liu, Martin Weiss, Peter Loskill
Pubblicato in: Advanced Healthcare Materials, Numero 13, 2024, ISSN 2192-2640
Editore: John Wiley and Sons Ltd
DOI: 10.1002/adhm.202302714