Coherent Raman Imaging for the Molecular Study of the OrigiN of diseases

Información del proyecto

CRIMSON

Identificador del acuerdo de subvención: 101016923

DOI

10.3030/101016923

Proyecto cerrado

Fecha de la firma de la CE 30 Noviembre 2020

Fecha de inicio 1 Diciembre 2020

Fecha de finalización 31 Mayo 2024

Financiado con arreglo a

• INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies - Information and Communication Technologies (ICT)

Coste total

€ 5 132 801,25

Aportación de la UE

€ 5 132 801,25

Coordinado por

POLITECNICO DI MILANO
Italy

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Documents, reports (1)

D5.3 Report on performed communication, dissemination and exploitation activities

Report on performed communication, dissemination and exploitation activities

Open Research Data Pilot (1)

D6.1 Data Management Plan

Data Management Plan

Websites, patent fillings, videos etc. (4)

D5.4 Preliminary communication kit

Preliminary communication kit that will be updated throughout the project

D5.5 Communication kit (final)

Communication kit in final version.

D5.1 Project website, graphical identity of the CRIMSON project, project flyer and database of stakeholders

Project website graphical identity of the CRIMSON project project flyer and database of stakeholders

D5.5 Communication kit (mid-term)

Communication kit updated at M18

Publicaciones

Peer reviewed articles (32)

Comparing Transmission- and Epi-BCARS: A Transnational Round Robin on Solid State Materials

Autores: Hempel, Franz; Vernuccio, Federico; König, Lukas; Buschbeck, Robin; Rüsing, Michael; Cerullo, Giulio; Polli, Dario; Eng, Lukas M.
Publicado en: Applied Optics, Edición Vol. 63, Edición 1, 2024, Página(s) 112-121, ISSN 1559-128X
Editor: Optica
DOI: 10.48550/arxiv.2306.09701

Sulfatide imaging identifies tumor cells in colorectal cancer peritoneal metastases

Autores: G. M. Sarcinelli, L. Varinelli, S. Ghislanzoni, F. Padelli, D. Lorenzini, A. Vingiani, M. Milione, M. Guaglio, S. Kusamura, M. Deraco, G. Pruneri, M. Gariboldi, D. Baratti, I. Bongarzone
Publicado en: Cancer & Metabolism, Edición 12, 2024, Página(s) 13, ISSN 2049-3002
Editor: BioMed Central Ltd, part of Springer Nature
DOI: 10.1186/s40170-024-00345-3

Feasibility studies of multimodal nonlinear endoscopy using multicore fiber bundles for remote scanning from tissue sections to bulk organs

Autores: Hyeonsoo Bae, Marko Rodewald, Tobias Meyer-Zedler, Thomas W. Bocklitz, Gregor Matz, Bernhard Messerschmidt, Adrian T. Press, Michael Bauer, Orlando Guntinas-Lichius, Andreas Stallmach, Michael Schmitt & Juergen Popp
Publicado en: Scientific Reports volume 13, Article number: 13779, Edición Scientific Reports volume 13, Article number: 13779, 2023, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-023-40944-6

Coherent Stokes Raman scattering microscopy (CSRS)

Autores: Sandro Heuke, Hervé Rigneault
Publicado en: Nature Communications, Edición 14, 2023, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-023-38941-4

Deep Ensemble Learning and Transfer Learning Methods for Classification of Senescent Cells from Nonlinear Optical Microscopy Images

Autores: Salvatore Sorrentino, Francesco Manetti, Arianna Bresci, Federico Vernuccio, Chiara Ceconello, Silvia Ghislanzoni, Italia Bongarzone, Renzo Vanna, Giulio Cerullo, Dario Polli
Publicado en: Front. Chem., Edición 11, 1213981, 2023, ISSN 2296-2646
Editor: Frontiers
DOI: 10.3389/fchem.2023.1213981

Noninvasive morpho-molecular imaging reveals early therapy-induced senescence in human cancer cells

Autores: Arianna Bresci, Jeong Hee Kim, Silvia Ghislanzoni, Francesco Manetti, Lintong Wu, Federico Vernuccio, Chiara Ceconello, Salvatore Sorrentino, Ishan Barman, Italia Bongarzone, Giulio Cerullo, Renzo Vanna, And Dario Polli
Publicado en: Science Advances, Edición 9, eadg6231, 2023, ISSN 2375-2548
Editor: American Association for the Advancement of Science
DOI: 10.1126/sciadv.adg6231

Reduced sulfatide content in deferoxamine-induced senescent HepG2 cells

Autores: Silvia Ghislanzoni, Gaia Martina Sarcinelli, Arianna Bresci, Francesco Manetti, Dario Polli, Antonella Tomassetti, Maria Teresa Radice, Italia Bongarzone
Publicado en: Int J Biochem Cell Biol ., Edición Vol. 159, 2023, ISSN 1357-2725
Editor: Pergamon Press Ltd.
DOI: 10.1016/j.biocel.2023.106419

Full-Spectrum CARS Microscopy of Cells and Tissues with Ultrashort White-Light Continuum Pulses

Autores: Federico Vernuccio, Renzo Vanna, Chiara Ceconello, Arianna Bresci, Francesco Manetti, Salvatore Sorrentino, Silvia Ghislanzoni, Flavia ambertucci, Omar Motiño, Isabelle Martins, Guido Kroemer, Italia Bongarzone, Giulio Cerullo, and Dario Polli
Publicado en: J. Phys. Chem., Edición B 127, 21, 2023, Página(s) 4733–4745, ISSN 0002-7863
Editor: American Chemical Society
DOI: 10.1021/acs.jpcb.3c01443

Experimental determination of shift-less aberration bases for sensorless adaptive optics in nonlinear microscopy

Autores: Benedetta Talone; Paolo Pozzi; Miriam Cavagnini; Dario Polli; Gianluca Pozzi; Jonathan Mapelli
Publicado en: Optics Express, Edición 29, 2021, Página(s) 37617-37627, ISSN 2334-2536
Editor: Optica
DOI: 10.1364/oe.435262

Selective Detection in Impulsive Low-Frequency Raman Imaging Using Shaped Probe Pulses

Autores: Siddarth Shivkumar, Dekel Ranann, Samuel Metais, Sisira Suresh, Nicolas Forget, Randy Bartels, Dan Oron, and Hervé Rigneault
Publicado en: Phys. Rev. Applied, Edición 19, 2023, ISSN 2643-1564
Editor: American Physical Society
DOI: 10.1103/physrevapplied.19.054075

Label-free multimodal nonlinear optical microscopy reveals features of bone composition in pathophysiological conditions

Autores: Benedetta Talone, Arianna Bresci, Francesco Manetti, Federico Vernuccio, Alejandro De La Cadena, Chiara Ceconello, Maria L. Schiavone, Stefano Mantero, Ciro Menale, Renzo Vanna, Giulio Cerullo, Cristina Sobacchi and Dario Polli
Publicado en: Front. Bioeng. Biotechnol., Edición 22, 10:1042680, 2022, ISSN 2296-4185
Editor: Frontiers
DOI: 10.3389/fbioe.2022.1042680

Design and test of a rigid endomicroscopic system for multimodal imaging and femtosecond laser ablation

Autores: Chenting Lai, Matteo Calvarese, Karl Reichwald, Hyeonsoo Bae, Mohammadsadegh Vafaeinezhad, Tobias Meyer-Zedler, Franziska Hoffmann, Anna Mühlig, Tino Eidam, Fabian Stutzki, Bernhard Messerschmidt, Herbert Gross, Michael Schmitt, Orlando Guntinas-Lichius, Jürgen Popp
Publicado en: Journal of Biomedical Optics, Edición Vol. 28, Edición 6, 2023, ISSN 1560-2281
Editor: SPIE
DOI: 10.1117/1.jbo.28.6.066004

Deep reinforcement learning control of white-light continuum generation

Autores: Carlo Michele Valensise; Alessandro Giuseppi; Giulio Cerullo; Dario Polli
Publicado en: Optica, Edición 8, 2021, Página(s) 239-242, ISSN 2334-2536
Editor: Optica
DOI: 10.1364/optica.414634

Ultrafast Spectral Tuning of a Fiber Laser for Time-Encoded Multiplex Coherent Raman Scattering Microscopy

Autores: Thomas Gottschall, Tobias Meyer-Zedler, Matthias Eibl, Tom Pfeiffer, Hubertus Hakert, Michael Schmitt, Robert Huber, Andreas Tünnermann, Jens Limpert, Juergen Popp
Publicado en:  J. Phys. Chem. B, Edición 127, 11, 2023, ISSN 0002-7863
Editor: American Chemical Society
DOI: 10.1021/acs.jpcb.2c09115

Double-modulations stimulated Raman scattering: how to image up to 16-fold faster

Autores: Sandro Heuke, Xavier Audier, Hervé Rigneault
Publicado en: Optics Letters, Edición 15; 48(2), 2023, Página(s) 423-426, ISSN 2334-2536
Editor: Optica
DOI: 10.1364/ol.467514

Photon-noise: Is a single-pixel camera better than point scanning? A signal-to-noise ratio analysis for Hadamard and Cosine positive modulation

Autores: Camille Scotté, Frédéric Galland and Hervé Rigneault
Publicado en: J. Phys. Photonics, Edición 5, 2023, ISSN 1742-6596
Editor: IOP Publishing
DOI: 10.48550/arxiv.2210.01915

Optical Diffraction Tomography and Raman Confocal Microscopy for the Investigation of Vacuoles Associated with Cancer Senescent Engulfing Cells

Autores: Silvia Ghislanzoni; Jeon Woong Kang; Arianna Bresci; Andrea Masella; Koseki J. Kobayashi-Kirschvink; Dario Polli; Italia Bongarzone; Peter T. C. So
Publicado en: Biosensors, Edición Vol 13, Iss 11, 2023, Página(s) 1-15, ISSN 2079-6374
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.20944/preprints202310.0573.v1

Broadband Four-Wave Mixing Enhanced by Plasmonic Surface Lattice Resonance and Localized Surface Plasmon Resonance in an Azimuthally Chirped Grating

Autores: Abhik Chakraborty, Parijat Barman, Ankit Kumar Singh, Xiaofei Wu, Denis A. Akimov, Tobias Meyer-Zedler, Stefan Nolte, Carsten Ronning, Michael Schmitt, Jürgen Popp, Jer-Shing Huang
Publicado en: Laser & Photonics Reviews, Edición Volume 17, Edición 7, 2023, ISSN 1863-8899
Editor: WILEY Online LIBRARY
DOI: 10.1002/lpor.202200958

Broadband stimulated Raman imaging based on multi-channel lock-in detection for spectral histopathology

Autores: Alejandro De la Cadena, Federico Vernuccio, Andrea Ragni, Giuseppe Sciortino, Renzo Vanna, Carino Ferrante, Natalia Pediconi, Carlo Valensise, Luca Genchi, Sergey P. Laptenok, Andrea Doni, Marco Erreni, Tullio Scopigno, Carlo Liberale, Giorgio Ferrari, Marco Sampietro, Giulio Cerullo, Dario Polli
Publicado en: APL Photonics, Edición 7, 2022, ISSN 2378-0967
Editor: APL Photonics
DOI: 10.1063/5.0093946

Removal of cross-phase modulation artifacts in ultrafast pump–probe dynamics by deep learning

Autores: A. Bresci; Michele Guizzardi; Carlo Michele Valensise; Fabio Marangi; Francesco Scotognella; Giulio Cerullo; Dario Polli
Publicado en: APL Photonics, Edición 6, 2021, Página(s) 076104, ISSN 2378-0967
Editor: American Institute of Physics (United States)
DOI: 10.1063/5.0057404

Nonlinear Optical Signal Generation Mediated by a Plasmonic Azimuthally Chirped Grating

Autores: Parijat Barman, Abhik Chakraborty, Denis A. Akimov, Ankit Kumar Singh, Tobias Meyer-Zedler, Xiaofei Wu, Carsten Ronning, Michael Schmitt, Jürgen Popp*, and Jer-Shing Huan
Publicado en: Nano Lett. 2022, 22, 24, 9914–9919, Edición Nano Lett. 2022, 22, 24, 9914–9919, 2022, Página(s) 9914–9919, ISSN 1530-6984
Editor: American Chemical Society
DOI: 10.1021/acs.nanolett.2c03348

Live Stimulated Raman Histology for the Near-Instant Assessment of Central Nervous System Samples

Autores: Romain Appay, Barbara Sarri, Sandro Heuke, Sébastien Boissonneau, Chang Liu, Etienne Dougy, Laurent Daniel, Didier Scavarda, Henry Dufour, Dominique Figarella-Branger, and Hervé Rigneault
Publicado en: Physical Chemistry B, Edición 127, 16, 2023, Página(s) 3624–3631, ISSN 1463-9076
Editor: Royal Society of Chemistry
DOI: 10.1021/acs.jpcb.3c01156

In vivo organoid growth monitoring by stimulated Raman histology

Autores: Barbara Sarri, Véronique Chevrier, Flora Poizat, Sandro Heuke, Florence Franchi, Louis De Franqueville, Eddy Traversari, Jean-Philippe Ratone, Fabrice Caillol, Yanis Dahel, Solène Hoibian, Marc Giovannini, Cécile de Chaisemartin, Romain Appay, Géraldine Guasch, Hervé Rigneault
Publicado en: npj Imaging, Edición 2, 2024, Página(s) 8, ISSN 2948-197X
Editor: Nature Partner Journals
DOI: 10.1038/s44303-024-00019-1

Comparison of denoising tools for the reconstruction of nonlinear multimodal images. Biomedical Optics Express

Autores: Rola Houhou, Elsie Quansah, Tobias Meyer-Zedler, Michael Schmitt, Franziska Hoffmann, Orlando Guntinas-Lichius, Jürgen Popp, and Thomas Bocklitz
Publicado en: Biomedical Optics Express, Edición volume 14 issue 7, 2023, Página(s) 3259-3278, ISSN 2156-7085
Editor: The Optical Society
DOI: 10.1364/boe.477384

Phototoxicity induced in living HeLa cells by focused femtosecond laser pulses: a data-driven approach

Autores: Benedetta Talone; M. Bazzarelli; Andrea Schirato; F. Dello Vicario; Daniele Viola; Emanuela Jacchetti; M. Bregonzio; Manuela Teresa Raimondi; Giulio Cerullo; Dario Polli
Publicado en: Biomed Opt Express, Edición 12, 2021, Página(s) 7886-7905, ISSN 2156-7085
Editor: The Optical Society
DOI: 10.1364/boe.441225

Fingerprint multiplex CARS at high speed based on supercontinuum generation in bulk media and deep learning spectral denoising

Autores: Federico Vernuccio, Arianna Bresci, Benedetta Talone, Alejandro De la Cadena, Chiara Ceconello, Stefano Mantero, Cristina Sobacchi, Renzo Vanna, Giulio Cerullo, and Dario Polli
Publicado en: Optics Express, Edición 30, 2022, ISSN 1094-4087
Editor: Optical Society of America
DOI: 10.1364/oe.463032

Multiplex Chemical Imaging Based on Broadband Stimulated Raman Scattering Microscopy

Autores: Alejandro, De la Cadena; Federico, Vernuccio; Benedetta, Talone; Arianna, Bresci; Chiara, Ceconello; Subir, Das; Renzo, Vanna; Giulio, Cerullo; Dario, Polli
Publicado en: Journal of Visualized Experiments, Edición 185: e63709, 2022, Página(s) 1-25, ISSN 1940-087X
Editor: MYJoVE Corporation
DOI: 10.3791/63709

Multi-Class Cancer Subtyping in Salivary Gland Carcinomas with MALDI Imaging and Deep Learning

Autores: David Pertzborn; Christoph Arolt; Günther Ernst; Oliver J. Lechtenfeld; Jan Kaesler; Daniela Pelzel; Orlando Guntinas-Lichius; Ferdinand von Eggeling; Franziska Hoffmann
Publicado en: Cancers, Edición 14(17), 2022, ISSN 2072-6694
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14174342

A Proposal to Perform High Contrast Imaging of Human Palatine Tonsil with Cross Polarized Optical Coherence Tomography

Autores: Gargi Sharma, Asha Parmar, Franziska Hoffmann, Katharina Geißler, Ferdinand von Eggeling, Orlando Guntinas-Lichius, Kanwarpal Singh
Publicado en: Photonics, Edición 9(4), 2022, ISSN 2304-6732
Editor: MDPI
DOI: 10.3390/photonics9040259

Artificial Intelligence in Classical and Quantum Photonics

Autores: Federico Vernuccio; Arianna Bresci; Valeria Cimini; Alessandro Giuseppi; Giulio Cerullo; Dario Polli; Carlo Michele Valensise
Publicado en: Laser & Photonics Reviews, Edición 16, 2022, Página(s) 2100399, ISSN 1863-8899
Editor: Wiley-VCH
DOI: 10.1002/lpor.202100399

Estimation of biological variance in coherent Raman microscopy data of two cell lines using chemometrics

Autores: Rajendhar Junjuri, Matteo Calvarese, MohammadSadegh Vafaeinezhad, Federico Vernuccio, Marco Ventura, Tobias Meyer-Zedler, Benedetta Gavazzoni, Dario Polli, Renzo Vanna, Italia Bongarzone, Silvia Ghislanzoni, Matteo Negro, Juergen Popp, Thomas Bocklitz
Publicado en: The Analyst, Edición 149, 2024, Página(s) 4395-4406, ISSN 0003-2654
Editor: Royal Society of Chemistry
DOI: 10.1039/d4an00648h

CARS Imaging Advances Early Diagnosis of Cardiac Manifestation of Fabry Disease

Autores: Elen Tolstik, Nairveen Ali, Shuxia Guo, Paul Ebersbach, Dorothe Möllmann, Paula Arias-Loza, Johann Dierks, Irina Schuler, Erik Freier, Jörg Debus, Hideo A. Baba, Peter Nordbeck, Thomas Bocklitz and Kristina Lorenz
Publicado en: International Journal of Molecular Sciences, Edición 23(10), 2022, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23105345

Conference proceedings (9)

Multimodal multiphoton and vibrational microscopy reveals early therapy-induced senescence in human tumors: a non-invasive tool to prevent the risk of cancer relapse

Autores: Arianna Bresci, Francesco Manetti, Silvia Ghislanzoni, Federico Vernuccio, Salvatore Sorrentino, Chiara Ceconello, Renzo Vanna, Italia Bongarzone, Giulio Cerullo, Dario Polli
Publicado en: Proc. SPIE, Edición Vol. 12384, 2023
Editor: SPIE
DOI: 10.1117/12.2648415

Label free highly multimodal nonlinear endoscope using hollow core fiber

Autores: Hervé Rigneault, Septier, Gaelle Brévalle, Naveen Gajendra, J Saucourt, Géraud Bouwmans, Andy Cassez, Matteo Conforti, Alexandre Kudlinski
Publicado en:  J. Phys. Chem. B, Edición 127, 16, 2023
Editor: American Chemical Society

Plug-And-Play Stimulated Raman Microscopy System for Broadband Coherent Vibrational Imaging

Autores: Francesco Crisafi, Benedetta Talone, Andrea Ragni, Gabriele Di Noia
Publicado en: (CLEO/Europe-EQEC) 2023 Conference on Lasers and Electro-Optics Europe & European Quantum Electronics Conference, 2023
Editor: European Physical Society
DOI: 10.1109/cleo/europe-eqec57999.2023.10231815

Video-rate wide-field broadband coherent anti-Stokes Raman scattering microscopy

Autores: Chiara Ceconello, Federico Vernuccio, Arianna Bresci, Francesco Manetti, Salvatore Sorrentino, Renzo Vanna, Giulio Cerullo, Dario Polli
Publicado en: Proc. SPIE, Edición Vol. 12390, 2023
Editor: SPIE
DOI: 10.1117/12.2650628

Ultra-compact widely tunable dual-wavelength fiber-based sources for CARS and SRS imaging (Conference Presentation)

Autores: Armin Hoffmann; Florian Just; Christian Gaida; Sven Breitkopf; Oliver Herrfurth; Tobias Meyer-Zedler; Jürgen Popp; Tino Eidam; Jens Limpert
Publicado en: Proc. SPIE, Edición Vol. PC12391, 2023
Editor: SPIE
DOI: 10.1117/12.2649987

Quantitative molecular absorption of cosmetic active molecules in human skin using coherent Raman imaging (CARS and SRS)

Autores: Hervé Rigneault, Barbara Sarri
Publicado en: Conference Papers, Photonics West, 2023
Editor: Photonics West

Live stimulated Raman histology for the near-instant assessment of central nervous system samples

Autores: Barbara Sarri; Sandro Heuke; Chang Liu; Sebastien Boissonneau; Hervé Rigneault; Romain Appay
Publicado en: Proc. SPIE, Edición Vol. PC12373, 2023, ISSN 1520-6106
Editor: American Chemical Society
DOI: 10.1117/12.2648086

Multimodal vibrational and multiphoton nonlinear optical microscopy as a non-invasive tool to prevent human tumor recurrence

Autores: Arianna Bresci, Francesco Manetti, Silvia Ghislanzoni, Federico Vernuccio, Salvatore Sorrentino, Chiara Ceconello, Renzo Vanna, Italia Bongarzone, Giulio Cerullo, Dario Polli
Publicado en: Proc. SPIE, Edición Vol. 12627, 2023
Editor: SPIE
DOI: 10.1117/12.2670918

High-speed vibrational microscopy and deep-learning algorithms to image cells and tissues

Autores: Dario Polli, Federico Vernuccio, Alejandro De la Cadena, Arianna Bresci, Chiara Ceconello, Francesco Manetti, Salvatore Sorrentino, Subir Das, Renzo Vanna, Giulio Cerullo
Publicado en: Proc. SPIE LASE, Edición Vol. PC12406, 2023
Editor: SPIE
DOI: 10.1117/12.2648736

Non-peer reviewed articles (1)

High-resolution Raman imaging of >300 cells from human patients affected by nine different leukemia subtypes: a global clustering approach

Autores: Renzo Vanna; Andrea Masella; Manuela Bazzarelli; Paola Ronchi; Aufried T. M. Lenferink; Cristina Tresoldi; Carlo Morasso; Marzia Bedoni; Giulio Cerullo; Dario Polli; Fabio Ciceri; Giulia De Poli; Matteo Bregonzio; Cees Otto
Publicado en: ChemRxiv, 2024, ISSN 2573-2293
Editor: ChemRxiv
DOI: 10.26434/chemrxiv-2024-xpzhc-v2