Coherent Raman Imaging for the Molecular Study of the OrigiN of diseases

Informazioni relative al progetto

CRIMSON

ID dell’accordo di sovvenzione: 101016923

DOI

10.3030/101016923

Progetto chiuso

Data della firma CE 30 Novembre 2020

Data di avvio 1 Dicembre 2020

Data di completamento 31 Maggio 2024

Finanziato da

• INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies - Information and Communication Technologies (ICT)

Costo totale

€ 5 132 801,25

Contributo UE

€ 5 132 801,25

Coordinato da

POLITECNICO DI MILANO
Italy

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Documents, reports (1)

D5.3 Report on performed communication, dissemination and exploitation activities

Report on performed communication, dissemination and exploitation activities

Open Research Data Pilot (1)

D6.1 Data Management Plan

Data Management Plan

Websites, patent fillings, videos etc. (4)

D5.4 Preliminary communication kit

Preliminary communication kit that will be updated throughout the project

D5.5 Communication kit (final)

Communication kit in final version.

D5.1 Project website, graphical identity of the CRIMSON project, project flyer and database of stakeholders

Project website graphical identity of the CRIMSON project project flyer and database of stakeholders

D5.5 Communication kit (mid-term)

Communication kit updated at M18

Pubblicazioni

Peer reviewed articles (32)

Comparing Transmission- and Epi-BCARS: A Transnational Round Robin on Solid State Materials

Autori: Hempel, Franz; Vernuccio, Federico; König, Lukas; Buschbeck, Robin; Rüsing, Michael; Cerullo, Giulio; Polli, Dario; Eng, Lukas M.
Pubblicato in: Applied Optics, Numero Vol. 63, Numero 1, 2024, Pagina/e 112-121, ISSN 1559-128X
Editore: Optica
DOI: 10.48550/arxiv.2306.09701

Sulfatide imaging identifies tumor cells in colorectal cancer peritoneal metastases

Autori: G. M. Sarcinelli, L. Varinelli, S. Ghislanzoni, F. Padelli, D. Lorenzini, A. Vingiani, M. Milione, M. Guaglio, S. Kusamura, M. Deraco, G. Pruneri, M. Gariboldi, D. Baratti, I. Bongarzone
Pubblicato in: Cancer & Metabolism, Numero 12, 2024, Pagina/e 13, ISSN 2049-3002
Editore: BioMed Central Ltd, part of Springer Nature
DOI: 10.1186/s40170-024-00345-3

Feasibility studies of multimodal nonlinear endoscopy using multicore fiber bundles for remote scanning from tissue sections to bulk organs

Autori: Hyeonsoo Bae, Marko Rodewald, Tobias Meyer-Zedler, Thomas W. Bocklitz, Gregor Matz, Bernhard Messerschmidt, Adrian T. Press, Michael Bauer, Orlando Guntinas-Lichius, Andreas Stallmach, Michael Schmitt & Juergen Popp
Pubblicato in: Scientific Reports volume 13, Article number: 13779, Numero Scientific Reports volume 13, Article number: 13779, 2023, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-023-40944-6

Coherent Stokes Raman scattering microscopy (CSRS)

Autori: Sandro Heuke, Hervé Rigneault
Pubblicato in: Nature Communications, Numero 14, 2023, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-023-38941-4

Deep Ensemble Learning and Transfer Learning Methods for Classification of Senescent Cells from Nonlinear Optical Microscopy Images

Autori: Salvatore Sorrentino, Francesco Manetti, Arianna Bresci, Federico Vernuccio, Chiara Ceconello, Silvia Ghislanzoni, Italia Bongarzone, Renzo Vanna, Giulio Cerullo, Dario Polli
Pubblicato in: Front. Chem., Numero 11, 1213981, 2023, ISSN 2296-2646
Editore: Frontiers
DOI: 10.3389/fchem.2023.1213981

Noninvasive morpho-molecular imaging reveals early therapy-induced senescence in human cancer cells

Autori: Arianna Bresci, Jeong Hee Kim, Silvia Ghislanzoni, Francesco Manetti, Lintong Wu, Federico Vernuccio, Chiara Ceconello, Salvatore Sorrentino, Ishan Barman, Italia Bongarzone, Giulio Cerullo, Renzo Vanna, And Dario Polli
Pubblicato in: Science Advances, Numero 9, eadg6231, 2023, ISSN 2375-2548
Editore: American Association for the Advancement of Science
DOI: 10.1126/sciadv.adg6231

Reduced sulfatide content in deferoxamine-induced senescent HepG2 cells

Autori: Silvia Ghislanzoni, Gaia Martina Sarcinelli, Arianna Bresci, Francesco Manetti, Dario Polli, Antonella Tomassetti, Maria Teresa Radice, Italia Bongarzone
Pubblicato in: Int J Biochem Cell Biol ., Numero Vol. 159, 2023, ISSN 1357-2725
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.biocel.2023.106419

Full-Spectrum CARS Microscopy of Cells and Tissues with Ultrashort White-Light Continuum Pulses

Autori: Federico Vernuccio, Renzo Vanna, Chiara Ceconello, Arianna Bresci, Francesco Manetti, Salvatore Sorrentino, Silvia Ghislanzoni, Flavia ambertucci, Omar Motiño, Isabelle Martins, Guido Kroemer, Italia Bongarzone, Giulio Cerullo, and Dario Polli
Pubblicato in: J. Phys. Chem., Numero B 127, 21, 2023, Pagina/e 4733–4745, ISSN 0002-7863
Editore: American Chemical Society
DOI: 10.1021/acs.jpcb.3c01443

Experimental determination of shift-less aberration bases for sensorless adaptive optics in nonlinear microscopy

Autori: Benedetta Talone; Paolo Pozzi; Miriam Cavagnini; Dario Polli; Gianluca Pozzi; Jonathan Mapelli
Pubblicato in: Optics Express, Numero 29, 2021, Pagina/e 37617-37627, ISSN 2334-2536
Editore: Optica
DOI: 10.1364/oe.435262

Selective Detection in Impulsive Low-Frequency Raman Imaging Using Shaped Probe Pulses

Autori: Siddarth Shivkumar, Dekel Ranann, Samuel Metais, Sisira Suresh, Nicolas Forget, Randy Bartels, Dan Oron, and Hervé Rigneault
Pubblicato in: Phys. Rev. Applied, Numero 19, 2023, ISSN 2643-1564
Editore: American Physical Society
DOI: 10.1103/physrevapplied.19.054075

Label-free multimodal nonlinear optical microscopy reveals features of bone composition in pathophysiological conditions

Autori: Benedetta Talone, Arianna Bresci, Francesco Manetti, Federico Vernuccio, Alejandro De La Cadena, Chiara Ceconello, Maria L. Schiavone, Stefano Mantero, Ciro Menale, Renzo Vanna, Giulio Cerullo, Cristina Sobacchi and Dario Polli
Pubblicato in: Front. Bioeng. Biotechnol., Numero 22, 10:1042680, 2022, ISSN 2296-4185
Editore: Frontiers
DOI: 10.3389/fbioe.2022.1042680

Design and test of a rigid endomicroscopic system for multimodal imaging and femtosecond laser ablation

Autori: Chenting Lai, Matteo Calvarese, Karl Reichwald, Hyeonsoo Bae, Mohammadsadegh Vafaeinezhad, Tobias Meyer-Zedler, Franziska Hoffmann, Anna Mühlig, Tino Eidam, Fabian Stutzki, Bernhard Messerschmidt, Herbert Gross, Michael Schmitt, Orlando Guntinas-Lichius, Jürgen Popp
Pubblicato in: Journal of Biomedical Optics, Numero Vol. 28, Numero 6, 2023, ISSN 1560-2281
Editore: SPIE
DOI: 10.1117/1.jbo.28.6.066004

Deep reinforcement learning control of white-light continuum generation

Autori: Carlo Michele Valensise; Alessandro Giuseppi; Giulio Cerullo; Dario Polli
Pubblicato in: Optica, Numero 8, 2021, Pagina/e 239-242, ISSN 2334-2536
Editore: Optica
DOI: 10.1364/optica.414634

Ultrafast Spectral Tuning of a Fiber Laser for Time-Encoded Multiplex Coherent Raman Scattering Microscopy

Autori: Thomas Gottschall, Tobias Meyer-Zedler, Matthias Eibl, Tom Pfeiffer, Hubertus Hakert, Michael Schmitt, Robert Huber, Andreas Tünnermann, Jens Limpert, Juergen Popp
Pubblicato in:  J. Phys. Chem. B, Numero 127, 11, 2023, ISSN 0002-7863
Editore: American Chemical Society
DOI: 10.1021/acs.jpcb.2c09115

Double-modulations stimulated Raman scattering: how to image up to 16-fold faster

Autori: Sandro Heuke, Xavier Audier, Hervé Rigneault
Pubblicato in: Optics Letters, Numero 15; 48(2), 2023, Pagina/e 423-426, ISSN 2334-2536
Editore: Optica
DOI: 10.1364/ol.467514

Photon-noise: Is a single-pixel camera better than point scanning? A signal-to-noise ratio analysis for Hadamard and Cosine positive modulation

Autori: Camille Scotté, Frédéric Galland and Hervé Rigneault
Pubblicato in: J. Phys. Photonics, Numero 5, 2023, ISSN 1742-6596
Editore: IOP Publishing
DOI: 10.48550/arxiv.2210.01915

Optical Diffraction Tomography and Raman Confocal Microscopy for the Investigation of Vacuoles Associated with Cancer Senescent Engulfing Cells

Autori: Silvia Ghislanzoni; Jeon Woong Kang; Arianna Bresci; Andrea Masella; Koseki J. Kobayashi-Kirschvink; Dario Polli; Italia Bongarzone; Peter T. C. So
Pubblicato in: Biosensors, Numero Vol 13, Iss 11, 2023, Pagina/e 1-15, ISSN 2079-6374
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.20944/preprints202310.0573.v1

Broadband Four-Wave Mixing Enhanced by Plasmonic Surface Lattice Resonance and Localized Surface Plasmon Resonance in an Azimuthally Chirped Grating

Autori: Abhik Chakraborty, Parijat Barman, Ankit Kumar Singh, Xiaofei Wu, Denis A. Akimov, Tobias Meyer-Zedler, Stefan Nolte, Carsten Ronning, Michael Schmitt, Jürgen Popp, Jer-Shing Huang
Pubblicato in: Laser & Photonics Reviews, Numero Volume 17, Numero 7, 2023, ISSN 1863-8899
Editore: WILEY Online LIBRARY
DOI: 10.1002/lpor.202200958

Broadband stimulated Raman imaging based on multi-channel lock-in detection for spectral histopathology

Autori: Alejandro De la Cadena, Federico Vernuccio, Andrea Ragni, Giuseppe Sciortino, Renzo Vanna, Carino Ferrante, Natalia Pediconi, Carlo Valensise, Luca Genchi, Sergey P. Laptenok, Andrea Doni, Marco Erreni, Tullio Scopigno, Carlo Liberale, Giorgio Ferrari, Marco Sampietro, Giulio Cerullo, Dario Polli
Pubblicato in: APL Photonics, Numero 7, 2022, ISSN 2378-0967
Editore: APL Photonics
DOI: 10.1063/5.0093946

Removal of cross-phase modulation artifacts in ultrafast pump–probe dynamics by deep learning

Autori: A. Bresci; Michele Guizzardi; Carlo Michele Valensise; Fabio Marangi; Francesco Scotognella; Giulio Cerullo; Dario Polli
Pubblicato in: APL Photonics, Numero 6, 2021, Pagina/e 076104, ISSN 2378-0967
Editore: American Institute of Physics (United States)
DOI: 10.1063/5.0057404

Nonlinear Optical Signal Generation Mediated by a Plasmonic Azimuthally Chirped Grating

Autori: Parijat Barman, Abhik Chakraborty, Denis A. Akimov, Ankit Kumar Singh, Tobias Meyer-Zedler, Xiaofei Wu, Carsten Ronning, Michael Schmitt, Jürgen Popp*, and Jer-Shing Huan
Pubblicato in: Nano Lett. 2022, 22, 24, 9914–9919, Numero Nano Lett. 2022, 22, 24, 9914–9919, 2022, Pagina/e 9914–9919, ISSN 1530-6984
Editore: American Chemical Society
DOI: 10.1021/acs.nanolett.2c03348

Live Stimulated Raman Histology for the Near-Instant Assessment of Central Nervous System Samples

Autori: Romain Appay, Barbara Sarri, Sandro Heuke, Sébastien Boissonneau, Chang Liu, Etienne Dougy, Laurent Daniel, Didier Scavarda, Henry Dufour, Dominique Figarella-Branger, and Hervé Rigneault
Pubblicato in: Physical Chemistry B, Numero 127, 16, 2023, Pagina/e 3624–3631, ISSN 1463-9076
Editore: Royal Society of Chemistry
DOI: 10.1021/acs.jpcb.3c01156

In vivo organoid growth monitoring by stimulated Raman histology

Autori: Barbara Sarri, Véronique Chevrier, Flora Poizat, Sandro Heuke, Florence Franchi, Louis De Franqueville, Eddy Traversari, Jean-Philippe Ratone, Fabrice Caillol, Yanis Dahel, Solène Hoibian, Marc Giovannini, Cécile de Chaisemartin, Romain Appay, Géraldine Guasch, Hervé Rigneault
Pubblicato in: npj Imaging, Numero 2, 2024, Pagina/e 8, ISSN 2948-197X
Editore: Nature Partner Journals
DOI: 10.1038/s44303-024-00019-1

Comparison of denoising tools for the reconstruction of nonlinear multimodal images. Biomedical Optics Express

Autori: Rola Houhou, Elsie Quansah, Tobias Meyer-Zedler, Michael Schmitt, Franziska Hoffmann, Orlando Guntinas-Lichius, Jürgen Popp, and Thomas Bocklitz
Pubblicato in: Biomedical Optics Express, Numero volume 14 issue 7, 2023, Pagina/e 3259-3278, ISSN 2156-7085
Editore: The Optical Society
DOI: 10.1364/boe.477384

Phototoxicity induced in living HeLa cells by focused femtosecond laser pulses: a data-driven approach

Autori: Benedetta Talone; M. Bazzarelli; Andrea Schirato; F. Dello Vicario; Daniele Viola; Emanuela Jacchetti; M. Bregonzio; Manuela Teresa Raimondi; Giulio Cerullo; Dario Polli
Pubblicato in: Biomed Opt Express, Numero 12, 2021, Pagina/e 7886-7905, ISSN 2156-7085
Editore: The Optical Society
DOI: 10.1364/boe.441225

Fingerprint multiplex CARS at high speed based on supercontinuum generation in bulk media and deep learning spectral denoising

Autori: Federico Vernuccio, Arianna Bresci, Benedetta Talone, Alejandro De la Cadena, Chiara Ceconello, Stefano Mantero, Cristina Sobacchi, Renzo Vanna, Giulio Cerullo, and Dario Polli
Pubblicato in: Optics Express, Numero 30, 2022, ISSN 1094-4087
Editore: Optical Society of America
DOI: 10.1364/oe.463032

Multiplex Chemical Imaging Based on Broadband Stimulated Raman Scattering Microscopy

Autori: Alejandro, De la Cadena; Federico, Vernuccio; Benedetta, Talone; Arianna, Bresci; Chiara, Ceconello; Subir, Das; Renzo, Vanna; Giulio, Cerullo; Dario, Polli
Pubblicato in: Journal of Visualized Experiments, Numero 185: e63709, 2022, Pagina/e 1-25, ISSN 1940-087X
Editore: MYJoVE Corporation
DOI: 10.3791/63709

Multi-Class Cancer Subtyping in Salivary Gland Carcinomas with MALDI Imaging and Deep Learning

Autori: David Pertzborn; Christoph Arolt; Günther Ernst; Oliver J. Lechtenfeld; Jan Kaesler; Daniela Pelzel; Orlando Guntinas-Lichius; Ferdinand von Eggeling; Franziska Hoffmann
Pubblicato in: Cancers, Numero 14(17), 2022, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14174342

A Proposal to Perform High Contrast Imaging of Human Palatine Tonsil with Cross Polarized Optical Coherence Tomography

Autori: Gargi Sharma, Asha Parmar, Franziska Hoffmann, Katharina Geißler, Ferdinand von Eggeling, Orlando Guntinas-Lichius, Kanwarpal Singh
Pubblicato in: Photonics, Numero 9(4), 2022, ISSN 2304-6732
Editore: MDPI
DOI: 10.3390/photonics9040259

Artificial Intelligence in Classical and Quantum Photonics

Autori: Federico Vernuccio; Arianna Bresci; Valeria Cimini; Alessandro Giuseppi; Giulio Cerullo; Dario Polli; Carlo Michele Valensise
Pubblicato in: Laser & Photonics Reviews, Numero 16, 2022, Pagina/e 2100399, ISSN 1863-8899
Editore: Wiley-VCH
DOI: 10.1002/lpor.202100399

Estimation of biological variance in coherent Raman microscopy data of two cell lines using chemometrics

Autori: Rajendhar Junjuri, Matteo Calvarese, MohammadSadegh Vafaeinezhad, Federico Vernuccio, Marco Ventura, Tobias Meyer-Zedler, Benedetta Gavazzoni, Dario Polli, Renzo Vanna, Italia Bongarzone, Silvia Ghislanzoni, Matteo Negro, Juergen Popp, Thomas Bocklitz
Pubblicato in: The Analyst, Numero 149, 2024, Pagina/e 4395-4406, ISSN 0003-2654
Editore: Royal Society of Chemistry
DOI: 10.1039/d4an00648h

CARS Imaging Advances Early Diagnosis of Cardiac Manifestation of Fabry Disease

Autori: Elen Tolstik, Nairveen Ali, Shuxia Guo, Paul Ebersbach, Dorothe Möllmann, Paula Arias-Loza, Johann Dierks, Irina Schuler, Erik Freier, Jörg Debus, Hideo A. Baba, Peter Nordbeck, Thomas Bocklitz and Kristina Lorenz
Pubblicato in: International Journal of Molecular Sciences, Numero 23(10), 2022, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23105345

Conference proceedings (9)

Multimodal multiphoton and vibrational microscopy reveals early therapy-induced senescence in human tumors: a non-invasive tool to prevent the risk of cancer relapse

Autori: Arianna Bresci, Francesco Manetti, Silvia Ghislanzoni, Federico Vernuccio, Salvatore Sorrentino, Chiara Ceconello, Renzo Vanna, Italia Bongarzone, Giulio Cerullo, Dario Polli
Pubblicato in: Proc. SPIE, Numero Vol. 12384, 2023
Editore: SPIE
DOI: 10.1117/12.2648415

Label free highly multimodal nonlinear endoscope using hollow core fiber

Autori: Hervé Rigneault, Septier, Gaelle Brévalle, Naveen Gajendra, J Saucourt, Géraud Bouwmans, Andy Cassez, Matteo Conforti, Alexandre Kudlinski
Pubblicato in:  J. Phys. Chem. B, Numero 127, 16, 2023
Editore: American Chemical Society

Plug-And-Play Stimulated Raman Microscopy System for Broadband Coherent Vibrational Imaging

Autori: Francesco Crisafi, Benedetta Talone, Andrea Ragni, Gabriele Di Noia
Pubblicato in: (CLEO/Europe-EQEC) 2023 Conference on Lasers and Electro-Optics Europe & European Quantum Electronics Conference, 2023
Editore: European Physical Society
DOI: 10.1109/cleo/europe-eqec57999.2023.10231815

Video-rate wide-field broadband coherent anti-Stokes Raman scattering microscopy

Autori: Chiara Ceconello, Federico Vernuccio, Arianna Bresci, Francesco Manetti, Salvatore Sorrentino, Renzo Vanna, Giulio Cerullo, Dario Polli
Pubblicato in: Proc. SPIE, Numero Vol. 12390, 2023
Editore: SPIE
DOI: 10.1117/12.2650628

Ultra-compact widely tunable dual-wavelength fiber-based sources for CARS and SRS imaging (Conference Presentation)

Autori: Armin Hoffmann; Florian Just; Christian Gaida; Sven Breitkopf; Oliver Herrfurth; Tobias Meyer-Zedler; Jürgen Popp; Tino Eidam; Jens Limpert
Pubblicato in: Proc. SPIE, Numero Vol. PC12391, 2023
Editore: SPIE
DOI: 10.1117/12.2649987

Quantitative molecular absorption of cosmetic active molecules in human skin using coherent Raman imaging (CARS and SRS)

Autori: Hervé Rigneault, Barbara Sarri
Pubblicato in: Conference Papers, Photonics West, 2023
Editore: Photonics West

Live stimulated Raman histology for the near-instant assessment of central nervous system samples

Autori: Barbara Sarri; Sandro Heuke; Chang Liu; Sebastien Boissonneau; Hervé Rigneault; Romain Appay
Pubblicato in: Proc. SPIE, Numero Vol. PC12373, 2023, ISSN 1520-6106
Editore: American Chemical Society
DOI: 10.1117/12.2648086

Multimodal vibrational and multiphoton nonlinear optical microscopy as a non-invasive tool to prevent human tumor recurrence

Autori: Arianna Bresci, Francesco Manetti, Silvia Ghislanzoni, Federico Vernuccio, Salvatore Sorrentino, Chiara Ceconello, Renzo Vanna, Italia Bongarzone, Giulio Cerullo, Dario Polli
Pubblicato in: Proc. SPIE, Numero Vol. 12627, 2023
Editore: SPIE
DOI: 10.1117/12.2670918

High-speed vibrational microscopy and deep-learning algorithms to image cells and tissues

Autori: Dario Polli, Federico Vernuccio, Alejandro De la Cadena, Arianna Bresci, Chiara Ceconello, Francesco Manetti, Salvatore Sorrentino, Subir Das, Renzo Vanna, Giulio Cerullo
Pubblicato in: Proc. SPIE LASE, Numero Vol. PC12406, 2023
Editore: SPIE
DOI: 10.1117/12.2648736

Non-peer reviewed articles (1)

High-resolution Raman imaging of >300 cells from human patients affected by nine different leukemia subtypes: a global clustering approach

Autori: Renzo Vanna; Andrea Masella; Manuela Bazzarelli; Paola Ronchi; Aufried T. M. Lenferink; Cristina Tresoldi; Carlo Morasso; Marzia Bedoni; Giulio Cerullo; Dario Polli; Fabio Ciceri; Giulia De Poli; Matteo Bregonzio; Cees Otto
Pubblicato in: ChemRxiv, 2024, ISSN 2573-2293
Editore: ChemRxiv
DOI: 10.26434/chemrxiv-2024-xpzhc-v2