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In-silico Development- and Clinical-Trial-Platform for Testing in-situ Tissue Engineered Heart Valves

Project description

In-silico prediction of safety and performance of a synthetic biodegradable heart valve

Valvular heart disease requires valve replacement or repair. Advances in tissue engineering offer the opportunity to develop a new class of heart valve replacements: synthetic biodegradable heart valves. To accelerate the development of these devices, the EU-funded SimInSitu project is proposing an in-silico model capable of predicting the device’s short- and long-term safety and performance. It will incorporate tissue-remodelling-algorithms, patient-specific-modelling, and device-modelling. All relevant components and processes will undergo an extensive verification, validation and uncertainty quantification programme to generate the necessary credibility and trustworthiness. The development of the in-silico model can facilitate the development of biodegradable devices, shorten the time to market, and contribute to development of a regulatory framework of in-silico methods.

Call for proposal

H2020-SC1-DTH-2018-2020

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Sub call

H2020-SC1-DTH-2020-1

Coordinator

4REALSIM SERVICES BV
Net EU contribution
€ 1 226 562,50
Address
Benschopperstraat 34
3401 DH Ijsselstein
Netherlands

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Region
West-Nederland Utrecht Utrecht
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 1 226 562,50

Participants (9)

UNIVERSITA DEGLI STUDI DI PALERMO
Italy
Net EU contribution
€ 652 720,00
Address
Piazza Marina 61
90133 Palermo

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Region
Isole Sicilia Palermo
Activity type
Higher or Secondary Education Establishments
Other funding
€ 652 720,00
ASSOCIATION POUR LA RECHERCHE ET LE DEVELOPPEMENT DES METHODES ET PROCESSUS INDUSTRIELS
France
Net EU contribution
€ 433 125,00
Address
Boulevard Saint Michel 60
75272 Paris

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Region
Ile-de-France Ile-de-France Paris
Activity type
Research Organisations
Other funding
€ 433 125,00
Third-party

Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.

INSTITUT MINES-TELECOM
France
Net EU contribution
€ 49 500,00
Address
19 Place Marguerite Perey
91120 Palaiseau

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Region
Ile-de-France Ile-de-France Essonne
Activity type
Higher or Secondary Education Establishments
Other funding
€ 49 500,00
LEARTIKER, SCOOP
Spain
Net EU contribution
€ 181 000,00
Address
Av/ Xemein, 12
48270 Markina-xemein

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Noreste País Vasco Bizkaia
Activity type
Research Organisations
Other funding
€ 181 000,00
XELTIS BV
Netherlands
Net EU contribution
€ 640 000,00
Address
De Lismortel R2 06 Cat Build 31
5612 AR Eindhoven

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Noord-Brabant Zuidoost-Noord-Brabant
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 640 000,00
CAPVIDIA
Belgium
Net EU contribution
€ 920 625,00
Address
Technologielaan 3
3001 Heverlee

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Vlaams Gewest Prov. Vlaams-Brabant Arr. Leuven
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 920 625,00
TECHNISCHE UNIVERSITAET GRAZ
Austria
Net EU contribution
€ 293 972,50
Address
Rechbauerstrasse 12
8010 Graz

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Region
Südösterreich Steiermark Graz
Activity type
Higher or Secondary Education Establishments
Other funding
€ 293 972,50
KATHOLIEKE UNIVERSITEIT LEUVEN
Belgium
Net EU contribution
€ 825 687,50
Address
Oude Markt 13
3000 Leuven

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Region
Vlaams Gewest Prov. Vlaams-Brabant Arr. Leuven
Activity type
Higher or Secondary Education Establishments
Other funding
€ 825 687,50
ISTITUTO MEDITERRANEO PER I TRAPIANTI E TERAPIE AD ALTA SPECIALIZZAZIONE SRL - ISMETT SRL
Italy
Net EU contribution
€ 187 500,00
Other funding
€ 187 500,00