In-silico prediction of safety and performance of a synthetic biodegradable heart valve
Valvular heart disease requires valve replacement or repair. Advances in tissue engineering offer the opportunity to develop a new class of heart valve replacements: synthetic biodegradable heart valves. To accelerate the development of these devices, the EU-funded SimInSitu project is proposing an in-silico model capable of predicting the device’s short- and long-term safety and performance. It will incorporate tissue-remodelling-algorithms, patient-specific-modelling, and device-modelling. All relevant components and processes will undergo an extensive verification, validation and uncertainty quantification programme to generate the necessary credibility and trustworthiness. The development of the in-silico model can facilitate the development of biodegradable devices, shorten the time to market, and contribute to development of a regulatory framework of in-silico methods.
Call for proposal
See other projects for this call
Funding SchemeRIA - Research and Innovation action