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In-silico Development- and Clinical-Trial-Platform for Testing in-situ Tissue Engineered Heart Valves

Project description

In-silico prediction of safety and performance of a synthetic biodegradable heart valve

Valvular heart disease requires valve replacement or repair. Advances in tissue engineering offer the opportunity to develop a new class of heart valve replacements: synthetic biodegradable heart valves. To accelerate the development of these devices, the EU-funded SimInSitu project is proposing an in-silico model capable of predicting the device’s short- and long-term safety and performance. It will incorporate tissue-remodelling-algorithms, patient-specific-modelling, and device-modelling. All relevant components and processes will undergo an extensive verification, validation and uncertainty quantification programme to generate the necessary credibility and trustworthiness. The development of the in-silico model can facilitate the development of biodegradable devices, shorten the time to market, and contribute to development of a regulatory framework of in-silico methods.

Call for proposal

H2020-SC1-DTH-2020-1
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Coordinator

4REALSIM SERVICES BV
Address
Benschopperstraat 34
3401 DH Ijsselstein
Netherlands
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
EU contribution
€ 1 226 562,50

Participants (8)

UNIVERSITA DEGLI STUDI DI PALERMO
Italy
EU contribution
€ 652 720
Address
Piazza Marina 61
90133 Palermo
Activity type
Higher or Secondary Education Establishments
ASSOCIATION POUR LA RECHERCHE ET LE DEVELOPPEMENT DES METHODES ET PROCESSUS INDUSTRIELS
France
EU contribution
€ 482 625
Address
Boulevard Saint Michel 60
75272 Paris
Activity type
Research Organisations
LEARTIKER, SCOOP
Spain
EU contribution
€ 181 000
Address
Av/ Xemein, 12
48270 Markina-xemein
Activity type
Research Organisations
XELTIS BV
Netherlands
EU contribution
€ 640 000
Address
De Lismortel R2 06 Cat Build 31
5612 AR Eindhoven
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
CAPVIDIA
Belgium
EU contribution
€ 920 625
Address
Technologielaan 3
3001 Heverlee
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
TECHNISCHE UNIVERSITAET GRAZ
Austria
EU contribution
€ 293 972,50
Address
Rechbauerstrasse 12
8010 Graz
Activity type
Higher or Secondary Education Establishments
KATHOLIEKE UNIVERSITEIT LEUVEN
Belgium
EU contribution
€ 825 687,50
Address
Oude Markt 13
3000 Leuven
Activity type
Higher or Secondary Education Establishments
ISTITUTO MEDITERRANEO PER I TRAPIANTI E TERAPIE AD ALTA SPECIALIZZAZIONE SRL - ISMETT SRL
Italy
EU contribution
€ 187 500
Address
Discesa Dei Giudici 4
90133 Palermo
Activity type
Other