Project description
In-silico prediction of safety and performance of a synthetic biodegradable heart valve
Valvular heart disease requires valve replacement or repair. Advances in tissue engineering offer the opportunity to develop a new class of heart valve replacements: synthetic biodegradable heart valves. To accelerate the development of these devices, the EU-funded SimInSitu project is proposing an in-silico model capable of predicting the device’s short- and long-term safety and performance. It will incorporate tissue-remodelling-algorithms, patient-specific-modelling, and device-modelling. All relevant components and processes will undergo an extensive verification, validation and uncertainty quantification programme to generate the necessary credibility and trustworthiness. The development of the in-silico model can facilitate the development of biodegradable devices, shorten the time to market, and contribute to development of a regulatory framework of in-silico methods.
Fields of science
Programme(s)
Funding Scheme
RIA - Research and Innovation action
Coordinator
3401 DH Ijsselstein
Netherlands
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Participants (9)
90133 Palermo
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75272 Paris
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Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.
91120 Palaiseau
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48270 Markina-xemein
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
5612 AR Eindhoven
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
3001 Heverlee
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
8010 Graz
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3000 Leuven
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90133 Palermo
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