Description du projet
Prédiction in silico de la sécurité et des performances d’une valve cardiaque synthétique biodégradable
Les maladies valvulaires cardiaques nécessitent un remplacement ou une réparation de la valve. Les avancées en matière d’ingénierie tissulaire offrent l’opportunité de développer une nouvelle classe de valves cardiaques de remplacement: des valves cardiaques synthétiques biodégradables. Afin d’accélérer le développement de ces dispositifs, le projet SimInSitu, financé par l’UE, propose un modèle in silico capable de prédire la sécurité et les performances à court et à long terme du dispositif. Il intégrera des algorithmes de remodélisation tissulaire, de modélisation spécifique au patient, et de modélisation du dispositif. Tous les composants et processus impliqués seront soumis à un programme complet de vérification, de validation et de quantification des incertitudes pour générer la crédibilité et la fiabilité suffisantes. Le développement du modèle in silico facilitera la conception de dispositifs biodégradables, réduira le délai de commercialisation, et contribuera à la création d’un cadre réglementaire pour les méthodes in silico.
Objectif
SimInSitu is aiming to develop a sophisticated in-silico method to predict the short- and long-term behavior of in-situ tissue engineered heart valves by combing advanced tissue remodeling algorithms with a personalized virtual heart modelling approach. The method will be specifically developed to predict the complex transformation process of biodegradable heart valves from the initially synthetic scaffold into a fully remodeled & functional valve. This transformation process, named ETR for Endogenous Tissue Restoration, is the core technology for a new generation of very promising biodegradable vascular device currently developed by Xeltis. ETR makes the use of animal derived tissue, which is used in the majority of commercially available bioprosthetic heart valves, obsolete and avoids thereby durability related issues and potentially minimized the need for reoperations. Though, significant progress was made during the past years in developing ERT based devices, it remains very challenging, costly, time-consuming, and rich with obstacles. New knowledge can only be generated through a tedious trial & error process (requiring preclinical and clinical studies), since the restorative process cannot be replicated in an in-vitro environment. Advanced Computer Modelling & Simulation technologies have the potential to overcome this limitation by allowing to test new designs, modified scaffold compositions, or other applications in a virtual patient-specific environment – in-silico. SimInSitu will not only develop such a computer model, but will also verify and validate it thoroughly by making use of the extensive in-vitro and in-vivo data available and where necessary will generate new data to support the credibility of this in-silico method. The availability of this computer model could contribute significantly to an acceleration of especially the ETR-device development and accelerate their translation into the clinic and market.
Programme(s)
Régime de financement
RIA - Research and Innovation actionCoordinateur
3401 NJ IJSSELSTEIN
Pays-Bas
L’entreprise s’est définie comme une PME (petite et moyenne entreprise) au moment de la signature de la convention de subvention.