Descripción del proyecto
El proceso autoinmune impulsado por linfocitos T conduce a una encefalitis crónica con neurodegeneración progresiva
El encéfalo es un órgano inmunoprivilegiado en el que las células residentes ejercen funciones inmunes limitadas. Sin embargo, en el caso de la esclerosis múltiple, una enfermedad autoinmune crónica inducida por linfocitos T, el tejido encefálico se transforma en un medio inmunoactivo. El proyecto financiado con fondos europeos T-Neuron tiene como objetivo descubrir los mecanismos de la transformación neuronal inducida por linfocitos T, concretamente las consecuencias funcionales del comportamiento invasivo de estas células. Estudios anteriores demostraron que los linfocitos T autoagresivos en las lesiones autoinmunes suelen estar en contacto directo con las neuronas o residen dentro del citoplasma de estas. Los ataques autoinmunes repetidos de la materia gris inducen una inflamación persistente y neurodegeneración. El proyecto analizará la hipótesis de que los linfocitos T contribuyen directamente al desarrollo de la enfermedad crónica al cambiar irreversiblemente las células residentes del encéfalo a un estado inflamatorio.
Objetivo
The TOPIC of this proposal is how a T-cell-driven autoimmune process can transform the brain into a chronically inflamed tissue afflicted by progressive neurodegeneration.
The brain is considered to be an immune-privileged organ because immune cells have restricted access to its tissue and its resident cells can only exert limited immune functions. However, in the course of multiple sclerosis, a T-cell-induced chronic autoimmune disease of the brain, such aspects change dramatically and the brain tissue is transformed into an immunoactive milieu. These changes go hand in hand with a gradual degeneration of the neuronal tissue. What steers this transformative process in the brain is not yet understood.
We have developed new experimental models and tools that enable us to follow and functionally test this transition from healthy into degenerating brain tissue in real time. We found that autoaggressive T cells within autoimmune lesions were frequently in direct contact with neurons or were partially or even completely inside the cytoplasm of neurons. Repeated T-cell-mediated autoimmune attacks of the CNS grey matter induce persistent inflammatory lesions with proceeding neurodegeneration. This leads us to the HYPOTHESIS that T cells not only trigger the initiation of autoimmune disease bouts but in addition directly contribute to the chronification of the disease by irreversibly shifting brain resident cells to an inflammatory program. The central AIM of this project is to uncover the mechanisms behind this T-cell-induced neuronal transformation process, particularly the functional consequences of the T-cell invasive behavior.
Our VISION is to shed new light on this previously unknown function of autoaggressive T cells within the CNS tissue and thereby pave the way for new and targeted strategies to prevent autoimmunity-driven degeneration of the central nervous system.
Ámbito científico
Programa(s)
Régimen de financiación
ERC-ADG - Advanced GrantInstitución de acogida
37075 Goettingen
Alemania