Descripción del proyecto
Eliminación de la necesidad de extraer implantes bioelectrónicos
Los sistemas electrónicos biorreabsorbibles representan un tipo de tecnología de nueva aparición en medicina de urgencias, reanimación y rehabilitación. Fabricados con materiales que se disuelven por completo y con velocidades de degradación programables tras su inserción en el cuerpo, el objetivo es eliminar la necesidad de tener que extraer los implantes bioelectrónicos y producir innovaciones sin residuos para la electrónica de consumo. En este contexto, el proyecto financiado con fondos europeos BioResORGEL desarrollará el primer ejemplo de dispositivo bioelectrónico orgánico biorreabsorbible que se degrada «in situ» mediante la acción de enzimas específicas. Sobre la base de química de materiales, electrónica orgánica y biología celular (biodegradación y toxicidad), los científicos del proyecto se centrarán en la integración en los dispositivos de componentes de alto rendimiento que sean corroídos por enzimas que excretan normalmente las células inmunitarias durante la inflamación y la regeneración tisular.
Objetivo
Bioresorbable bioelectronics aim to produce technologies that monitor/modulate biological functions and safely integrate into life and the environment. It prospects to eliminate the need for bioelectronic implants retrieval and to produce zero waste solutions for consumer electronics.
The integration of degradable substrates with water-soluble electronic components (metals and semiconductors) led to the first examples of bioresorbable electronic implants. A key challenge is to develop devices combining high performance, stable operation, and controlled degradation at the end of their life cycle. Current hydrolysable materials suffer from inadequate lifetime, uncontrolled bulk degradation, and/or poor performance. Advanced bioresorbable microelectronics would require components that degrade in biological environments by the action of enzymes – something that cannot be achieved with conventional metal-oxide semiconductors.
Conjugated polymers offer transport of both ions and electrons, low operating voltages, and flexibility – features exploited to improve state-of-the-art bioelectronic devices and interfaces – and, most importantly, the potential to undergo enzymatic breakdown. Yet, there is currently no example of a conjugated polymer and device thereof combining all the required properties.
This project develops the first example of bioresorbable organic bioelectronic devices that are degraded in situ by the action of specific enzymes. It integrates aspects from materials chemistry (polymer design), organic electronics (device design), and cellular biology (biodegradation and toxicity). Key focus is to integrate device components that provide high performance and that are eroded by enzymes normally secreted by immune cells during inflammation and tissue regeneration. This interdisciplinary approach suggests a promising future across different fields – from fundamental aspects of polymers degradation and toxicity to the next generation bioelectronic interfaces.
Ámbito científico
- natural scienceschemical sciencespolymer sciences
- medical and health sciencesbasic medicineimmunology
- natural sciencesphysical scienceselectromagnetism and electronicssemiconductivity
- medical and health sciencesmedical biotechnologyimplants
- natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsenzymes
Palabras clave
Programa(s)
Régimen de financiación
MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)Coordinador
100 44 Stockholm
Suecia