Descrizione del progetto
Eliminare la necessità di recupero dell’impianto bioelettronico
I sistemi elettronici bioriassorbibili rappresentano una classe di tecnologia emergente nella medicina d’urgenza, nel recupero e nella riabilitazione. Costruiti con materiali che si dissolvono completamente, con tassi programmabili dopo l’inserimento nel corpo, il loro obiettivo è quello di eliminare la necessità di recupero degli impianti bioelettronici e di produrre soluzioni a «zero rifiuti» per l’elettronica di consumo. In questo contesto, il progetto BioResORGEL, finanziato dall’UE, svilupperà il primo esempio di dispositivi bioelettronici organici bioriassorbibili che vengono degradati in situ dall’azione di enzimi specifici. Attingendo alla chimica dei materiali, all’elettronica organica e alla biologia cellulare (biodegradazione e tossicità), il progetto si concentrerà sull’integrazione di componenti di dispositivi ad alte prestazioni che vengono erosi da enzimi normalmente secreti dalle cellule immunitarie durante l’infiammazione e la rigenerazione dei tessuti.
Obiettivo
Bioresorbable bioelectronics aim to produce technologies that monitor/modulate biological functions and safely integrate into life and the environment. It prospects to eliminate the need for bioelectronic implants retrieval and to produce zero waste solutions for consumer electronics.
The integration of degradable substrates with water-soluble electronic components (metals and semiconductors) led to the first examples of bioresorbable electronic implants. A key challenge is to develop devices combining high performance, stable operation, and controlled degradation at the end of their life cycle. Current hydrolysable materials suffer from inadequate lifetime, uncontrolled bulk degradation, and/or poor performance. Advanced bioresorbable microelectronics would require components that degrade in biological environments by the action of enzymes – something that cannot be achieved with conventional metal-oxide semiconductors.
Conjugated polymers offer transport of both ions and electrons, low operating voltages, and flexibility – features exploited to improve state-of-the-art bioelectronic devices and interfaces – and, most importantly, the potential to undergo enzymatic breakdown. Yet, there is currently no example of a conjugated polymer and device thereof combining all the required properties.
This project develops the first example of bioresorbable organic bioelectronic devices that are degraded in situ by the action of specific enzymes. It integrates aspects from materials chemistry (polymer design), organic electronics (device design), and cellular biology (biodegradation and toxicity). Key focus is to integrate device components that provide high performance and that are eroded by enzymes normally secreted by immune cells during inflammation and tissue regeneration. This interdisciplinary approach suggests a promising future across different fields – from fundamental aspects of polymers degradation and toxicity to the next generation bioelectronic interfaces.
Campo scientifico
- natural scienceschemical sciencespolymer sciences
- medical and health sciencesbasic medicineimmunology
- natural sciencesphysical scienceselectromagnetism and electronicssemiconductivity
- medical and health sciencesmedical biotechnologyimplants
- natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsenzymes
Parole chiave
Programma(i)
Argomento(i)
Meccanismo di finanziamento
MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)Coordinatore
100 44 Stockholm
Svezia