Brain Imaging Genetics of reading

Descripción del proyecto

Un análisis más detallado sobre la genética del comportamiento lector

El objetivo del proyecto Reading BIG, financiado con fondos europeos, es determinar el acervo genético del comportamiento lector mediante el empleo de marcadores neuroanatómicos relacionados con este proceso. A lo largo de esta investigación se identificarán pequeños efectos genéticos que contribuyen a las rutas biológicas relevantes para el comportamiento lector. Los investigadores del proyecto intentarán esclarecer si la influencia genética en el rendimiento lector está determinada por la morfología del cerebro. Para ello, utilizarán datos conductuales y hologenómicos, así como de imágenes cerebrales, para obtener una mayor comprensión de la relación entre los genes y las competencias lectoras. Además, se emplearán los genes como una herramienta para establecer vínculos y correlaciones entre los marcadores neuroanatómicos y el comportamiento lector.

Objetivo

Our ability to read is a must to navigate our current society, and despite the large variability in skill within the general population, it is often taken for granted. This project aims to help elucidate the mechanisms from genes to reading behaviour, by identifying anatomical brain imaging markers correlated to reading ability using an automated pipeline that can be used in the context of large imaging genetic datasets. We need to systematically characterise how reading expertise is reflected in the brain in order to be able to ask questions about its genetics underpinnings in large datasets without behavioural reading measures. We need to identify small genetic effects that additively contribute to the ready-to-read brain because it will pinpoint to relevant biological pathways that are the substrate of reading ability. We need to understand the extend to which the same genetic markers influence reading and its brain correlates, and whether genetic influences on reading performance are mediated through brain morphology, to help discern between different risk profiles for reading difficulties.
BIG READING integrates behavioural, brain imaging and genome-wide data in automated scalable pipelines to gain a deeper understanding of the link between genes and reading behaviour. I will analyse structural imaging markers correlated to reading-related traits in deeply phenotyped datasets of the general population to systematically characterise how reading expertise is reflected in the brain. I will perform heritability and genome-wide association scans in datasets with tens of thousands of participants to identify small genetic effects that additively contribute to the ready-to-read brain. I will perform genetic overlap analyses to define the extend of shared influence of genes on reading and its brain correlates and use genes as instruments to make causal inferences between brain markers and reading ability. This project will provide a foundation for future studies on how

Ámbito científico (EuroSciVoc)

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