Description du projet
Un examen approfondi de la génétique du comportement de lecture
Le projet Reading BIG, financé par l’UE, tente d’élucider le contexte génétique du comportement de lecture en utilisant des marqueurs d’imagerie cérébrale anatomique liés à la capacité de lecture. L’étude identifiera de petits effets génétiques contribuant aux voies biologiques pertinentes du comportement de lecture. Les chercheurs tenteront d’élucider si l’influence génétique sur les performances de lecture est médiée par la morphologie du cerveau. À cette fin, ils utiliseront des données sur le comportement, l’imagerie cérébrale et le génome entier pour mieux comprendre le lien entre les gènes et les capacités de lecture. En outre, ils utiliseront les gènes comme instruments pour établir des liens et des corrélations entre les marqueurs cérébraux et le comportement de lecture.
Objectif
Our ability to read is a must to navigate our current society, and despite the large variability in skill within the general population, it is often taken for granted. This project aims to help elucidate the mechanisms from genes to reading behaviour, by identifying anatomical brain imaging markers correlated to reading ability using an automated pipeline that can be used in the context of large imaging genetic datasets. We need to systematically characterise how reading expertise is reflected in the brain in order to be able to ask questions about its genetics underpinnings in large datasets without behavioural reading measures. We need to identify small genetic effects that additively contribute to the ready-to-read brain because it will pinpoint to relevant biological pathways that are the substrate of reading ability. We need to understand the extend to which the same genetic markers influence reading and its brain correlates, and whether genetic influences on reading performance are mediated through brain morphology, to help discern between different risk profiles for reading difficulties.
BIG READING integrates behavioural, brain imaging and genome-wide data in automated scalable pipelines to gain a deeper understanding of the link between genes and reading behaviour. I will analyse structural imaging markers correlated to reading-related traits in deeply phenotyped datasets of the general population to systematically characterise how reading expertise is reflected in the brain. I will perform heritability and genome-wide association scans in datasets with tens of thousands of participants to identify small genetic effects that additively contribute to the ready-to-read brain. I will perform genetic overlap analyses to define the extend of shared influence of genes on reading and its brain correlates and use genes as instruments to make causal inferences between brain markers and reading ability. This project will provide a foundation for future studies on how
Mots‑clés
Programme(s)
Appel à propositions
(s’ouvre dans une nouvelle fenêtre) H2020-MSCA-IF-2020
Voir d’autres projets de cet appelRégime de financement
MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)Coordinateur
20009 San Sebastian
Espagne